A5101455337- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Coral and Marine Ecosystems Studies
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Microbial Community Ecology and Physiology
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Marine and coastal plant biology
- Fungal and yeast genetics research
- Marine and fisheries research
- Muscle Physiology and Disorders
- Nuclear Structure and Function
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Marine animal studies overview
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Environmental DNA in Biodiversity Studies
- Adenosine and Purinergic Signaling
- Enzyme Structure and Function
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
Ruijin Hospital
2014-2025
Inserm
2016-2025
Université Côte d'Azur
2015-2025
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Centre Hospitalier Universitaire de Nice
2014-2024
Aix-Marseille Université
2024
Gilson (France)
2024
Shanghai Jiao Tong University
2017-2023
Université Claude Bernard Lyon 1
2007-2023
In the yeast Saccharomyces cerevisiae , telomere elongation is negatively regulated by repeat-binding protein Rap1p, such that a narrow length distribution of repeat tracts observed. This regulation was shown to function independently orientation repeats. The number repeats at an individual reduced when hybrid proteins containing Rap1p carboxyl terminus were targeted there heterologous DNA-binding domain. extent this tract shortening proportional molecules, consistent with feedback mechanism...
Abstract The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, single-blind, placebo-controlled (29 patients/group) phase II trial to validate previous findings and explore potential mechanisms. Patients treated umbilical cord-derived MSCs exhibited shorter hospital stay ( P = 0.0198) less time required for symptoms remission 0.0194) than...
Abstract Cellular senescence affects many physiological and pathological processes is characterized by durable cell cycle arrest, an inflammatory secretory phenotype metabolic reprogramming. Here, using dynamic transcriptome metabolome profiling in human fibroblasts with different subtypes of senescence, we show that a homoeostatic switch results glycerol-3-phosphate (G3P) phosphoethanolamine (pEtN) accumulation links lipid metabolism to the gene expression programme. Mechanistically,...
Transcriptional repression at the silent mating-type loci in yeast requires targeting of information regulator (Sir) proteins through specific interactions formed cis-acting silencer elements. We show here that a reporter gene flanked by two functional silencers is not repressed when integrated >200 kb from telomere. Repression restored creation new telomere 13 or elevated expression SIR1, SIR3, and/or SIR4. Coupled represses an additive manner, suggesting all three factors are limiting...
AbstractWe investigated the control of telomere length by human telomeric proteins TRF1 and TRF2. To this end, we established telomerase-positive cell lines in which targeting these to specific telomeres could be induced. We demonstrate that their leads shortening. This indicates act cis repress elongation. Inhibition telomerase activity a modified oligonucleotide did not further increase pace erosion caused targeting, suggesting itself is target regulation. In contrast, TRF2 inhibition have...
The DNA damage-dependent poly(ADP-ribose) polymerase-2 (PARP-2) is, together with PARP-1, an active player of the base excision repair process, thus defining its key role in genome surveillance and protection. Telomeres are specialized DNA-protein structures that protect chromosome ends from being recognized processed as strand breaks. In mammals, telomere protection depends on T2AG3 repeat binding protein TRF2, which has been shown to remodel telomeres into large duplex loops (t-loops)....
We present the sequence of gene malK which encodes a component system for maltose transport in E.coli K12. also determined position deletion (S50) fuses to following lamB; malK-lamB protein hyrbid contains allof protein. The mRNA corresponding last two thirds could form stable stem and loop structures. protein, as deduced from sequence, would include 370 residues correspond molecular weight 40700. well comparisions with ndh are discussed terms location function