A5101937633- Circular RNAs in diseases
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Advanced Nanomaterials in Catalysis
- Immune cells in cancer
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Fudan University
2023-2025
Zhongshan Hospital
2023-2025
Second Affiliated Hospital of Nanchang University
2019-2020
Nanchang University
2019-2020
The activation of nanoparticles (NPs) in the tumor microenvironment exerts synergistic therapeutic effects with chemotherapy against multiple cancers. In this study, an NP system prepared using biocompatible MIL-100 NPs was studied as effective vehicle to deliver oxaliplatin for hepatocellular carcinoma treatment. were coated polydopamine (PDA) and NH2-PEGTK-COOH then loaded create multi-functional Oxa@MIL-PDA-PEGTK. Oxa@MIL-PDA-PEGTK is activated microenvironment, causing generation...
T cell exhaustion is a critical obstacle for durable treatment response in hepatocellular carcinoma (HCC). Developing drugs that control tumor growth and simultaneously bolster immune function of great significance. Although high-mobility group box 2 (HMGB2) has been reported to be crucial HCC prognosis, its role the microenvironment remains unclear. Here, we found HMGB2 + CD8 cells as being associated with resistance anti–PD-1 through single-cell RNA sequencing. Mechanistically, impaired...
The current study aimed to explore the role of circular RNA circ‐TCF4.85 and its downstream target microRNA‐486‐5p (miR‐486‐5p) in hepatocellular carcinoma (HCC) development. Circ‐TCF4.85 was detected be highly expressed HCC tissues. Next, we found that silencing repressed cell proliferation, invasion, migration, while enhancing apoptosis. In addition, biotin‐coupled probe pull‐down miRNA capture assays, as well fluorescence situ hybridization, confirmed could bind miR‐486‐5p. rescue...
This study aimed to investigate the functions of circular RNA circMYLK (hsa_circ_0002768) in development hepatocellular carcinoma (HCC) and identify underlying mechanisms circMYLK/miR29a/KMT5C axis.Quantitative real-time polymerase chain reaction (qRT-PCR) was utilized explore expressions circMYLK, miR-29a KMT5C HCC tissues cells. A potential miRNA (miR-29a) regulated by also explored, target relationship between confirmed. FISH, qRT-PCR, Western blotting, dual-luciferase reporter assays...