A5107116654- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Gut microbiota and health
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Statistical Methods in Clinical Trials
- Adenosine and Purinergic Signaling
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Peptidase Inhibition and Analysis
- Synthesis and Biological Evaluation
- Tea Polyphenols and Effects
- Integrated Circuits and Semiconductor Failure Analysis
- PARP inhibition in cancer therapy
- Calcium signaling and nucleotide metabolism
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
Center for Cancer Research
2025
Aarhus University Hospital
2021-2024
Aarhus University
2019-2023
Massachusetts General Hospital
2023
Improved risk stratification is needed for patients with localized prostate cancer. This study characterized and assessed the prognostic potential of distinct immune cell infiltration patterns in tumor microenvironment. Using tissue microarrays, multiplex immunohistochemistry/immunofluorescence, automated digital pathology, we analyzed radical prostatectomy specimens from two large patient cohorts (training: n = 470; validation: 333) to determine levels seven types malignant versus benign...
Abstract Background With over 350,000 estimated deaths worldwide in 2018, prostate cancer (PCa) continues to be a major health concern and significant cause of cancer-associated mortality among men. While general is considered disease the human genome, there growing body evidence suggesting that changes healthy microbiota could play vital role development, progression, and/or treatment outcome. Methods Using metatranscriptomic approach, we annotated microbial reads obtained from total RNA...
Prostate cancer (PCa) is a highly heterogeneous disease in terms of its molecular makeup and clinical prognosis. The prostate tumor microenvironment (TME) hypothesized to play an important role driving aggressiveness, but precise mechanisms remain elusive. In our study, we used spatial transcriptomics explore for the first time gene expression heterogeneity within primary tumors from patients with metastatic disease. total, analyzed 5459 tissue spots three PCa comprising castration-resistant...
Abstract T cell exhaustion is a major driver of immune checkpoint blockade (ICB) resistance and clinically effective strategies to prevent or reverse restore ICB sensitivity are lacking. CD38, an ecto-enzyme involved in NAD+ catabolism, highly expressed exhausted CD8+ cells human melanoma, yet its role remains be elucidated. Here we show that CD38+CD8+ enriched during tumor progression following unsuccessful treatment strongly associated with melanoma. Chronic TCR activation type I...
Abstract Current prognostic tools cannot clearly distinguish indolent and aggressive prostate cancer (PC). We hypothesized that analyzing individual contributions of epithelial stromal components in localized PC (LPC) could improve risk stratification, as subtypes may have been overlooked due to the emphasis on malignant cells. Hence, we derived molecular using gene expression analysis LPC samples from prostatectomy patients (cohort 1, n = 127) validated these two independent cohorts 2, 406,...
Cancer immunotherapies such as bispecific T-cell engagers have seen limited adoption in prostate cancer (PC), possibly due to differing levels of receptor expression and effector infiltration between patients inherent defects engager design.CD8+ PSMA were determined by RNA sequencing primary PC tissue samples from 126 with localised 17 metastatic PC. Prognostic value was assessed through clinical parameters, including CAPRA-S risk score. A panel albumin-fused anti-CD3 × anti-PSMA different...
Abstract Elevated prostate-specific antigen (PSA) levels often lead to unnecessary and possibly harmful transrectal ultrasound guided biopsy, e.g. when the biopsy is negative or contains only low-grade insignificant cancer, unlikely become symptomatic in man’s normal lifespan. A model based on four-kallikrein markers blood (commercialized as 4Kscore) predicts risk of Grade group 2 higher prostate cancer at reducing biopsies. We assessed whether these results extend a single institution...
<h3>Background</h3> Terminally exhausted CD8+ T cells, resulting from chronic antigen exposure in the tumor microenvironment, are defined by loss of effector function, decreased proliferative potential, and associated with limited response to immune checkpoint blockade (ICB).<sup>1</sup> CD38 is an ecto-enzyme, involved NAD+ catabolism.<sup>2</sup> that was shown be expressed terminally cells melanoma correlate lack ICB,<sup>3</sup> although its specific role cell exhaustion therapeutic...
Abstract The tumor microenvironment influences prostate cancer aggressiveness, and by focusing on how different changes to the can affect cancer, we aimed identify novel stromal subtypes in localized (LPC), characterize these subtypes, utilize increase accuracy risk stratification. Subtype identification was conducted using non-negative matrix factorization with consensus clustering a stroma-specific expression signature RNA sequencing data. A discovery cohort (127 LPC patients) two...