A5082615491- Wnt/β-catenin signaling in development and cancer
- Developmental Biology and Gene Regulation
- Assisted Reproductive Technology and Twin Pregnancy
- RNA Research and Splicing
- Hippo pathway signaling and YAP/TAZ
- Reproductive Biology and Fertility
- Axon Guidance and Neuronal Signaling
- Nasal Surgery and Airway Studies
- Immunodeficiency and Autoimmune Disorders
- Tissue Engineering and Regenerative Medicine
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Bone fractures and treatments
- Infant Health and Development
- Inflammatory mediators and NSAID effects
- Reproductive Health and Technologies
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Neuroscience of respiration and sleep
- Congenital heart defects research
Bob Jones University
2022
University of Missouri
2010-2016
Center for Life Sciences
2012
During hindbrain development, facial branchiomotor neurons (FBM neurons) migrate from medial rhombomere (r) 4 to lateral r6. In zebrafish, mutations in planar cell polarity genes celsr2 and frizzled3a block caudal migration of FBM neurons. Here, we investigated the role cadherins Celsr1-3, Fzd3 neuron mice. Celsr1 mutants (knock-out Crash alleles), was compromised often migrated rostrally into r2 r3, as well laterally. These phenotypes were not caused by defects patterning or neuronal...
The proper development and maturation of neuronal circuits require precise migration component neurons from their birthplace (germinal zone) to final positions. Little is known about the effects aberrant position on functioning organized groups, especially in mammals. Here, we investigated formation properties brainstem respiratory looptail (Lp) mutant mice which facial motor closely apposed some fail migrate due loss function Wnt/Planar Cell Polarity (PCP) protein Vangl2. Using calcium...
Acetaminophen is a common analgesic, but its potential effects on early embryonic development are not well understood. Previous studies using zebrafish (Danio rerio) have described the of acetaminophen liver and physiology, few gross physiological morphological defects. Using high non-embryonic lethal dose acetaminophen, we probed for defects in craniofacial cartilage development. Strikingly, treatment caused severe defects, primarily affecting both presence morphology pharyngeal...
In the developing hindbrain, facial branchiomotor (FBM) neurons migrate caudally from rhombomere 4 (r4) to r6 establish circuit that drives jaw movements. Although mechanisms regulating initiation of FBM neuron migration are well defined, those directionality not. mutants lacking Wnt/planar cell polarity (PCP) component Celsr1, many inappropriately rostrally into r3. We hypothesized Celsr1 normally blocks inappropriate rostral by suppressing chemoattraction towards Wnt5a in r3 and...