A5045107415- Neurogenesis and neuroplasticity mechanisms
- Developmental Biology and Gene Regulation
- Pancreatic function and diabetes
- Zebrafish Biomedical Research Applications
- Pancreatitis Pathology and Treatment
- Axon Guidance and Neuronal Signaling
- Adenosine and Purinergic Signaling
- Wnt/β-catenin signaling in development and cancer
- Diabetes and associated disorders
Washington University in St. Louis
2023-2024
University of Missouri
2018-2022
Precise positioning of neurons resulting from cell division and migration during development is critical for normal brain function. Disruption neuronal can cause a myriad neurological disorders. To investigate the functional consequences defective on circuit function, we studied zebrafish frizzled3a (fzd3a) loss-of-function mutant off-limits (olt) where facial branchiomotor (FBM) fail to migrate out their birthplace. A jaw movement assay, which measures opening (gape), showed that frequency...
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident secretory protein that reduces inflammation and promotes proliferation in pancreatic β cells. Numerous studies have highlighted the potential of MANF as a therapeutic agent for diabetes mellitus (DM), making it essential to understand mechanisms underlying MANF's functions. In our previous search molecule mediates signaling, we identified Neuroplastin (NPTN) binding partner localizes on cell...
Abstract Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident secretory protein that reduces inflammation and promotes proliferation in pancreatic β cells. Numerous studies have highlighted the potential of MANF as a therapeutic agent for diabetes mellitus (DM), making it essential to understand mechanisms underlying MANF’s functions. In our previous search molecule mediates signaling, we identified Neuroplastin (NPTN) binding partner localizes...
In the developing hindbrain, facial branchiomotor (FBM) neurons migrate caudally from rhombomere 4 (r4) to r6 establish circuit that drives jaw movements. Although mechanisms regulating initiation of FBM neuron migration are well defined, those directionality not. mutants lacking Wnt/planar cell polarity (PCP) component Celsr1, many inappropriately rostrally into r3. We hypothesized Celsr1 normally blocks inappropriate rostral by suppressing chemoattraction towards Wnt5a in r3 and...