A5033112195- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- interferon and immune responses
- Phagocytosis and Immune Regulation
- Viral Infections and Immunology Research
- Whipple's Disease and Interleukins
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- RNA Research and Splicing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- T-cell and B-cell Immunology
- Colorectal Cancer Surgical Treatments
- Trace Elements in Health
- Healthcare cost, quality, practices
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Fibrosis and Remodeling
- Renal Diseases and Glomerulopathies
- DNA Repair Mechanisms
- Dialysis and Renal Disease Management
- RNA modifications and cancer
University Hospital Schleswig-Holstein
2020-2024
University of Lübeck
2020-2024
German Centre for Cardiovascular Research
2023
University of Göttingen
2014-2021
Universitätsmedizin Göttingen
2021
Ferroptosis, a type of iron-dependent programmed cell death distinct from apoptosis, necroptosis, and other types death, is characterized by lipid peroxidation, reactive oxygen species production, mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury. Therefore, become major focus translational research. However, despite its involvement pathological conditions, there are no pharmacologic inhibitors...
Abstract The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would fundamentally improve the therapy RIPK1-dependent organ damage in stroke, myocardial infarction, kidney failure, systemic inflammatory response syndrome. Additionally, it could ameliorate or prevent multi-organ failure induced by cytokine release context hyperinflammation, as seen COVID-19 patients....
The RIP homotypic interaction motif (RHIM) is a conserved protein domain that approximately 18–22 amino acids in length. In humans, four proteins carrying RHIM domains have been identified: receptor-interacting serine/threonine kinase (RIPK) 1, RIPK3, Z-DNA-binding 1 (ZBP1), and TIR domain-containing adapter-inducing IFN-β (TRIF), which are all major players necroptosis, distinct form of regulated cell death. Necroptosis mostly presumed to be fail-safe death, occurring cells apoptosis...
Abstract Background Peritoneal dialysis (PD) remains underutilised in Germany, prompting the initiation of Sustainable Intensification Dialysis Schleswig–Holstein (SKIP-SH) project. The SKIP-SH cohort study aims to demonstrate presumed benefits PD, including enhanced quality life and reduced healthcare personnel requirements, generate data strengthen use PD. Methods prospective recruits patients with advanced chronic kidney disease (CKD) their caregivers. Comprehensive data, demographic...
A shift between two dimer conformations has been proposed for the transcription factor STAT1 (signal transducer and activator of 1) which links DNA binding parallel to tyrosine dephosphorylation antiparallel as consecutive important steps in interferon- γ (IFNγ)-mediated signalling. However, neither kinetics nor molecular mechanisms involved this conformational transition have determined so far.Our results demonstrated that dissociation dimers into monomers their subsequent re-association...
In this study, we addressed the functional significance of co-operative DNA binding cytokine-driven transcription factor STAT1 (signal transducer and activator 1) in an experimental murine model acute myocardial infarction (MI). knock-in mice expressing a phenylalanine-to-alanine substitution at position 77 amino-terminal domain were examined for early clinical effects produced by ligation left anterior descending coronary artery (LAD), established MI. The F77A mutation has been previously...
Despite excellent loco-regional control by multimodal treatment of locally advanced rectal cancer, a substantial portion patients succumb to this disease. As many effects are mediated via reactive oxygen species (ROS), we evaluated the effect single nucleotide polymorphisms (SNPs) in ROS-related genes on clinical outcome. Based literature, eight SNPs seven were assayed. Eligible (n = 287) diagnosed with UICC stage II/III cancer treated multimodally starting neoadjuvant radiochemotherapy...
Murine cytomegalovirus protein M45 contains a RIP homotypic interaction motif (RHIM) that is sufficient to confer protection of infected cells against necroptotic cell death. Mechanistically, the N-terminal region drives rapid self-assembly into homo-oligomeric amyloid fibrils, and interacts with endogenous RHIM domains receptor-interacting serine/threonine kinases (RIPK) 1, RIPK3, Z-DNA-binding Toll/interleukin-1 receptor domain-containing adaptor-inducing interferon-β. Remarkably, all four...