A5053215370- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Infant Nutrition and Health
- Immunotherapy and Immune Responses
- Surfactants and Colloidal Systems
- Skin and Cellular Biology Research
- Skin Protection and Aging
- Ocular Surface and Contact Lens
- Magnolia and Illicium research
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Synthesis of β-Lactam Compounds
- Nanopore and Nanochannel Transport Studies
- Lipid metabolism and disorders
- Photodynamic Therapy Research Studies
- Glycosylation and Glycoproteins Research
- Sesame and Sesamin Research
- Psoriasis: Treatment and Pathogenesis
- Macrophage Migration Inhibitory Factor
Alexandria University
2015-2024
Brown University
2024
Harvard University
2019-2021
Despite extensive progress in the field of cancer nanotheranostics, clinical development biocompatible theranostic nanomedicine remains a formidable challenge. Herein, we engineered silk-sericin-tagged inorganic nanohybrids for efficient treatment and imaging cells. The developed nanocarriers are anticipated to overcome premature release chemotherapeutic drug pemetrexed (PMX), enhance colloidal stability layered double hydroxides (LDHs), maintain luminescence properties ZnO quantum dots...
While the treatment regimen of certain types breast cancer involves a combination hormonal therapy and chemotherapy, outcomes are limited due to difference in pharmacokinetics both agents that hinders their simultaneous selective delivery cells. Herein, we report hybrid carrier system for targeted aromatase inhibitor exemestane (EXE) methotrexate (MTX). EXE was physically loaded within liquid crystalline nanoparticles (LCNPs), while MTX chemically conjugated lactoferrin (Lf) by carbodiimide...
Despite current progress in the development of targeted therapies for cancer treatment, there is a lack convenient therapeutics colorectal (CRC). Lactoferrin nanoparticles (Lf NPs) are promising drug delivery system therapy. However, numerous obstacles impede their oral delivery, including instability against stomach enzymes and premature uptake during passage through small intestine. Microencapsulation Lf NPs offer great solution these obstacles. It can protect payloads from degradation...
Aim: Lactoferrin (LF)-targeted gliadin nanoparticles (GL-NPs) were developed for targeted oral therapy of hepatocellular carcinoma. Materials & methods: Celecoxib and diosmin incorporated in the hydrophobic matrix GL-NPs whose surface was decorated with LF by electrostatic interaction binding to asialoglycoprotein receptors overexpressed liver cancer cells. Results: Targeted showed enhanced cytotoxic activity increased cellular uptake tumor cells compared nontargeted NPs. Moreover, they...
Abstract: The aim of this study is to develop a locally acting nasal delivery system triamcinolone acetonide (TA) for the maintenance therapy allergic rhinitis. effect encapsulating TA in different nanocarriers on its mucosal permeation and retention as well vivo deposition has been studied. A comparative was established between polymeric oil core nanocapsules (NCs), lipid such nanoemulsion (NE), nanostructured carriers (NLCs). elaborated were compared with suspension commercially available...
Background: Cetuximab (CTX) is a glycosylated anti-EGFR monoclonal antibody of great interest in the treatment non-melanoma skin cancers. Its intravenous administration associated with severe side effects. This first report on noninvasive iontophoretic-targeted topical delivery CTX to skin.Methods: Iontophoretic transport (0.5 mA/cm2) was studied as function formulation pH (4, 5.5 and 7) duration current application (2, 4 8 h). cutaneous biodistribution determined; electrotransport...
Abstract: In this study, an optimized nanodispersible oral dosage form (containing a lactate ester) was developed for cilostazol (CZL). CZL is phosphodiesterase inhibitor used intermittent claudication. We aimed to improve the dissolution rate and absorption of giving it better chance bioavailability, evaluate its stability on storage. Suitable compositions nanoemulsion preconcentrate formulations were screened via solubility compatibility tests. Response surface methodology desirability...
Diflunisal is a NSAID used in acute and long term management of pain inflammation associated with osteoarthritis, rheumatoid arthritis symptoms primary dysmenorrhea. However, its oral use side effects such as peptic ulceration, dyspepsia, gastrointestinal disturbances bleeding. The aim this work was to develop lecithin organogels (LO) transdermal delivery system for diflunisal study human skin penetration ability comparison an optimized microemulsion-based hydrogel. Ternary phase diagrams...
While breast cancer remains a global health concern, the elaboration of rationally designed drug combinations coupled with advanced biocompatible delivery systems offers new promising treatment venues. Herein, we repurposed rosuvastatin (RST) based on its selective tumor apoptotic effect and combined it antimetabolite pemetrexed (PMT) tumor-sensitizing polyphenol honokiol (HK). This synergistic three-drug combination was incorporated into protein polysaccharide nanohybrids fabricated by...
This study was conducted to elucidate the chemopreventive potential, cytotoxic, and suppression of cellular metastatic activity etodolac (ETD)-loaded nanocarriers.To esteem effect charge composition nanovectors on their performance, four types vectors namely, negative lipid nanovesicles; phosalosomes (N-Phsoms), positive (P-Phsoms), nanostructured carriers (NLCs) polymeric alginate polymer (AlgNPs) were prepared compared. ETD used as a model cyclo-oxygenase-2 (COX-2) inhibitor evaluate...
Marwa Ahmed Sallam*a, Adel Mohamed Motawaaa & Sana Mortadaaa Department of Industrial Pharmacy, Faculty Alexandria University, Egypt