A5048143254- Immunotherapy and Immune Responses
- Immune cells in cancer
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Fluorescence Microscopy Techniques
- Retinoids in leukemia and cellular processes
- Multiple Sclerosis Research Studies
- Renal Diseases and Glomerulopathies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Lipid metabolism and disorders
- Cutaneous lymphoproliferative disorders research
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders Research
- Signaling Pathways in Disease
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Ovarian function and disorders
- Thermal Regulation in Medicine
- Genetic and Kidney Cyst Diseases
- Spinal Cord Injury Research
- Cerebrospinal fluid and hydrocephalus
- Photodynamic Therapy Research Studies
Harvard University
2020-2025
Dr. D. Y. Patil Medical College, Hospital and Research Centre
2023
Dr. D.Y. Patil Vidyapeeth, Pune
2023
Institute of Chemical Technology
2020
Multiple sclerosis (MS) is an incurable autoimmune disease and currently treated by systemic immunosuppressants with off-target side effects. Although aberrant myeloid function often observed in MS plaques the central nervous system (CNS), role of cells therapeutic intervention overlooked. Here, we developed a cell-based strategy to reduce burden experimental encephalomyelitis (EAE), mouse model progressive MS. We monocyte-adhered microparticles ("backpacks") for activating cell phenotype...
Natural killer (NK) cell therapies have emerged as a potential therapeutic approach to various cancers. Their efficacy, however, is limited by their low persistence and anergy. Current approaches sustain NK in vivo include genetic modification, activation via pretreatment, or coadministration of supporting cytokines antibodies. Such exhibit efficacy vivo, part due the reversal effect within immunosuppressive tumor microenvironment off-target toxicity. Here, we report material-based address...
The choroid plexus (ChP) of the brain plays a central role in orchestrating recruitment peripheral leukocytes into nervous system (CNS) through blood-cerebrospinal fluid (BCSF) barrier pathological conditions, thus offering unique niche to diagnose CNS disorders. We explored whether magnetic resonance imaging ChP could be optimized for mild traumatic injury (mTBI). mTBI induces subtle, yet influential, changes and is currently severely underdiagnosed. hypothesized that sufficient alterations...
Abstract Adoptive cell therapies are dramatically altering the treatment landscape of cancer. However, solid tumors remains a major unmet need, in part due to limited adoptive infiltration into tumor and immunosuppressive microenvironment. The heterogeneity presence nonresponders also call for development antigen‐independent therapeutic approaches. Myeloid cells offer such an opportunity, given their large microenvironment, as triple negative breast utility is hindered by phenotypic...
Abstract Traumatic brain injury (TBI) is a debilitating disease with no current therapies outside of acute clinical management. While acute, controlled inflammation important for debris clearance and regeneration after injury, chronic, rampant plays significant adverse role in the pathophysiology secondary injury. Immune cell hold unique therapeutic potential modulation, due to their active sensing migration abilities. Macrophages are particularly suited this task, given macrophages...
Polymer-drug conjugates are developed for the topical ratiometric delivery of a synergistic drug pair to treat skin cancers.
Background Macrophages have been classically associated with their innate immune functions of responding to acute injury or pathogenic insult, but they largely overlooked as primary initiators adaptive responses. Here, we demonstrate that adoptively transferred macrophages, optimal activation prior administration, act a potent cellular cancer therapeutic platform against murine melanoma model. Method The macrophage therapy was prepared from bone marrow-derived pretreated ex vivo an cocktail...
B cells, despite their several unique functionalities, remain largely untapped for use as an adoptive cell therapy and are limited to in vitro antibody production. cells can be easily sourced, they possess excellent lymphoid-homing capabilities, act antigen-presenting (APCs), offering alternative dendritic (DCs), which have shown efficacy the clinical setting. Soluble factors such IL-4 anti-CD40 enhance activation, survival, capabilities of cells; however, it is difficult attain sufficiently...
Abstract Immune checkpoint inhibitors (ICIs) represent new therapeutic candidates against glioblastoma multiforme (GBM); however, their efficacy is clinically limited due to both local and systemic immunosuppressive environments. Hence, approaches that stimulate immune environments can improve the of ICIs. Here, we report an adoptive cell therapy employing neutrophils (NE) are activated via surface attachment drug‐free disk‐shaped backpacks, termed Cyto‐Adhesive Micro‐Patches (CAMPs) for...
Abstract Subcutaneous (subQ) injection is a common route for delivering biotherapeutics, wherein pharmacokinetics largely influenced by drug transport in complex subQ tissue microenvironment. The selection of good candidates with beneficial injections currently limited lack reliable testing models. To address this limitation, we report here Co-Culture Tissue-on-a-chip Injection Simulation (SubCuTIS). SubCuTIS possesses 3D coculture architecture, and it allows facile quantitative...
Introduction: Polycystic Ovarian Syndrome (PCOS) is an endocrinopathy with a complex metabolic disorder. PCOS characterized by reproductive hormonal imbalances leading to the clinical presentation of hyperandrogenism and infertility. also showing increased prevalence several other conditions such as obesity, dyslipidemia, hypertension, syndrome type 2 diabetes mellitus (DM2) when compared women without PCOS. The principal symptoms in patients are irregular menstruation, acne, excessive...
Abstract Skin cancer is the most common class of malignancies in humans with increasing incidence worldwide. Although surgery remains treatment approach, relapses after necessitate other options. There an clinical demand for topical treatments skin that can improve drug's cutaneous localization while limiting systemic absorption. In this study, hyaluronic acid (HA) conjugates are successfully synthesized by attaching a third‐generation retinoid (bexarotene) and histone deacetylase inhibitor...