A5025505202- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Antibiotic Resistance in Bacteria
- Probiotics and Fermented Foods
- Plant-Microbe Interactions and Immunity
- Fungal and yeast genetics research
- Meat and Animal Product Quality
- Crystallography and molecular interactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Organometallic Compounds Synthesis and Characterization
- Crystal structures of chemical compounds
- Gut microbiota and health
- Microbial Natural Products and Biosynthesis
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- TiO2 Photocatalysis and Solar Cells
- Synthesis and Biological Evaluation
- Antifungal resistance and susceptibility
- Photodynamic Therapy Research Studies
- Phytochemistry and biological activities of Ficus species
- Advanced oxidation water treatment
- Electron Spin Resonance Studies
- Advanced Photocatalysis Techniques
- Plant Pathogens and Fungal Diseases
Slovak University of Technology in Bratislava
2015-2025
Due to its slow degradation rate, polycaprolactone (PCL) is frequently used in biomedical applications. This study deals with the development of antibacterial nanofibers based on PCL and halloysite nanotubes (HNTs). Thanks a combination HNTs, prepared can be as low-cost nanocontainers for encapsulation wide variety substances, including drugs, enzymes, DNA. In our work, HNTs were nanocarrier erythromycin (ERY) model active compound range activity. Nanofibers HNT/ERY by electrospinning. The...
This work compares the prevalence of antibiotic resistant coliform bacteria in hospital wastewater effluents Slovak (SR) and Czech Republic (ČR). It also describes selected isolates view resistance mechanism virulence factor. The highest number multidrug was detected samples from Valašské Meziříčí More than half showed phenotype as well strong ability to form biofilm. In 42% efflux pump overproduction together with tetA tetE genes. production extended-spectrum β-lactamases encoded mainly by...
Donkey milk is a very promising matrix for the isolation of new potential starter cultures with probiotic properties. We isolated, identified, and compared technological properties donkey isolate D23 those goat isolates G15 G17 bovine C3 C9. All were identified as Lacticaseibacillus paracasei using matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF-MS) polymerase chain reaction (PCR) assays (determination species-specific DNA fragments). Like isolates, was...
Understanding the interplay between antifungal resistance, stress adaptation, and virulence in Aspergillus fumigatus is critical for more effective treatment outcomes. In this study, we investigate six clinical isolates of A. from hospitals Czech Republic, focusing on their resistance profiles, responses, survival mechanisms under pressure. Notably, have shown that azole-susceptible strains were able to form persister cells supra-MIC concentrations, highlighting an emerging non-genetic...
The antimicrobial activity of 3-methyl-5-isopropyl (or ethyl) 6-methyl-4-nitro-phenyl-1,4-dihydropyridine-3,5-dicarboxylate derivatives was evaluated. Prokaryotes (bacteria) appeared to be more sensitive their than were eukaryotes (filamentous fungi). best antibacterial shown by derivative 33, which able inhibit the growth Mycobacterium smegmatis (MIC33 = 9 μg.ml−1), Staphylococcus aureus 25 and Escherichia coli 100 μg.ml−1). In addition, 4 demonstrated its power on acid-fast bacterial...
The first total synthesis of the potent antibiotic berkeleylactone A is described in 10 steps with an overall yield 9.5%. key step our concise route a late-stage, highly diastereoselective, sulfa-Michael addition. 16-membered macrocyclic lactone was formed via ring closing metathesis and subsequent chemoselective reduction. absolute stereochemical configuration confirmed by single-crystal X-ray analysis. Synthetic tested against several methicillin-resistant Staphylococcus aureus strains,...
Fighting resistance to antibiotics and chemotherapeutics has brought bioactive peptides the fore. Peptaibols are short α-aminoisobutyric acid-containing produced by Trichoderma species. Here, we studied production of peptaibols atroviride O1 evaluated their antibacterial anticancer activity against drug-sensitive multidrug-resistant bacterium cancer cell lines. This was substantiated an analysis peptaibol synthetase-encoding gene. Atroviridins, 20-residue were detected using MALDI-TOF mass...
Among the many consumers in Slovakia, smoothies are nowadays gaining popularity. Smoothie drinks prepared from raw fruits and vegetables. Therefore, their microbiological safety depends on hygiene standards. The aim of this work was to monitor quantify selected sensitive antibiotic-resistant microorganisms present collected smoothies. Twenty analyzed smoothie samples were six food service establishments (fresh bars) capital city Bratislava. Antibiotic-resistant bacteria found at least one...
Raw foodstuffs have been marked as a healthier alternative in the context of nutrient content and are becoming more popular with consumers. Thermally untreated foods may represent microbiological risk connected possible presence antimicrobial resistance. The aim this study was to prove that raw food beverages such smoothies milk be source antibiotic-resistant coliform bacteria resistant genes. majority isolates (110) were identified Enterobacter spp., Escherichia coli, species Klebsiella...
Novel TEMPO and PROXYL derivatives reveal (quasi)reversible redox behavior. The EWG-substituents increase their oxidation potential in comparison to the EDG-groups. Unlike pyrrolidinyl derivatives, piperidinyl nitroxides inhibit growth of<italic>Staphylococcus</italic>sp.
Three silver(I) dipeptide complexes [Ag(GlyGly)]n(NO3)n (AgGlyGly), [Ag2(GlyAla)(NO3)2]n (AgGlyAla) and [Ag2(HGlyAsp)(NO3)]n (AgGlyAsp) were prepared, investigated characterized by vibrational spectroscopy (mid-IR), elemental thermogravimetric analysis mass spectrometry. For AgGlyGly, X-ray crystallography was also performed. Their stability in biological testing media verified time-dependent NMR measurements. vitro antimicrobial activity evaluated against selected pathogenic microorganisms....
Reaction of an ethanolic solution N-salicylidene- l -glutamatodiaquacopper(II) monohydrate with pyridine, 2-methylpyridine, 4-methylpyridine, 2-aminopyridine, 2,6-diaminopyridine, quinoline, 2-methylquinoline, 4-methylquinoline or 3-methylisoquinoline resulted in solid products containing complexes the type Cu(sal- -glu)L distorted square-pyramidal coordination geometry. The were characterized by elemental analysis, electronic spectroscopy and magnetic susceptibility measurements....