Abstract Background ADH1B rs1229984 and ALDH2 rs671 are the specifically prevalent functional variants in East Asians. These variants, which result a dramatic change enzyme activity, highly associated with alcohol‐related disorders cancer. Previous studies focusing on additive synergic effects of few inconsistent. The aim research was to evaluate associations risks disorder Methods This cohort study enrolled 42,665 participants from Taiwan Precision Medicine Initiative database, including...

Demoralization is a common problem in oral cancer patients owing to the chronic and severe nature of their affliction. However, association between demoralization patient's spiritual needs, quality life, suicidal ideation remains unclear. This study aims provide insights into possible links among its effects on ideation.We examined 155 Taiwanese inpatients Taichung Veterans General Hospital, Taiwan, using following three rating scales: (a) Scale Mandarin Version (DS-MV), (b) Spiritual...

Obstructive sleep apnea (OSA) is a serious disorder characterized by repetitive episodes of paused or shallow breathing during sleep. Patients with OSA often have excessive daytime sleepiness. The role cigarette smoking in remains controversial. aim this study was to examine the relationship between and OSA.In retrospective chart review, we reviewed 18-month laboratory charts central Taiwan. We collected data regarding sleep, current status, sex, age, body mass index (BMI), neck...

Hsu W-Y, Chiu N-Y, Liu J-T, Wang C-H, Chang T-G, Liao Y-C, Kuo P-I. Sleep quality in heroin addicts under methadone maintenance treatment. Background: disturbance is a common phenomenon among opiate addicts. The side effects of addiction or withdrawal might result sleep disturbance. However, their problems be related to sedative medication abuse, alcohol abuse relapse. an important issue this population. Objective: To evaluate the prevalence disorders receiving treatment (MMT) and analyse...

With decreasing mortality, the quality of life, spiritual needs, and mental health breast cancer patients have become increasingly important. Demoralization is a poor prognostic factor for patients. The extent demoralization in its association with these factors remains unclear. This cross-sectional study was conducted at Taiwanese medical center. We enrolled 121 participants (34 high 87 low demoralization, as per Mandarin Version Scale). High associated reduced sleep quality, interests....

Abstract Background Tinnitus affects approximately 740 million adults globally, involving hearing, emotion, and sleep systems. However, studies using polysomnography pure-tone audiometry (PTA) are limited. We aimed to assess the correlation between tinnitus quality, characteristics, depression PTA. Methods In this cross-sectional study, we divided participants into non-tinnitus groups. included 100 outpatients (65 with tinnitus, 35 without) from a medical center in Taiwan, who underwent...

Abstract Background Depression is a prevalent mental health concern, impacting nearly 3.8% of the global population. The strong link between depression and sleep-related disorders has been widely acknowledged. Persistent issues not only increase relapse recurrence but also necessitate adjustments in medication regimens. However, sleep architecture changes sleep- related are seldom discussed. Some shared neurobiological factors these conditions pose challenge. This study bridges gap by...

KCNQ4 encodes a voltage-gated potassium channel essential for ion balance and membrane potential regulation in inner ear hair cells. Mutations are associated with late-onset, high-frequency hearing loss that progressively worsens. This study aimed to compare carriers of the c.546C>G variant non-carriers examine relationship between this mutation loss, tinnitus, cardiovascular diseases. case-control used data from Taiwan Precision Medicine Initiative (TPMI) at Taichung Veterans General...

Opioid use disorder is a cause for concern globally. This study aimed to optimize methadone dose adjustments using mixed modeling and machine learning.

Individuals with substance use disorders, particularly those alcohol disorder (AUD), have a high risk of suicide. Therefore, identifying factors for suicide in these individuals is crucial.This retrospective study reviewed the medical records AUD who participated an treatment program central Taiwan during 2019-2020. We collected data using Cut down, Annoyed, Guilty, and Eye-opener questionnaire, Alcohol Use Disorders Identification Test (AUDIT), Brief Michigan Alcoholism Screening (MAST),...

Non‐clinical schizotypy was found to be related poorer Wisconsin Card‐Sorting Test (WCST) performance, but the results were inconsistent. Two subgroups, higher negative–higher positive and lower negative–lower (15 vs 16), selected from top bottom quartiles of negative scale scores Schizotypal Personality Questionnaire (SPQ) completed by 177 healthy volunteers, respectively. The SPQ score subgroup had significantly performance regarding categories WCST than subgroup. Subjects with...

Female adolescents are more prone to depression compared with male adolescents, and is often associated poor attentional control problematic internet use (PIU). Attentional includes both focusing shifting functions. Focusing refers the ability direct attention a task despite distractions. Shifting flexibly switch between different tasks. This study examines mediating role of PIU. high school college students (n = 476) in Taiwan participated survey administered at three time points over...

Methadone maintenance therapy (MMT) is a well-established and effective treatment for heroin use disorders. Whether frontal lobe function demoralization serve as suitable prognostic outcome assessment factors remains unknown. A quasi-experimental study was conducted with single-group repeated-measures design at medical center mental hospital in Taiwan. We enrolled 70 participants (39 completed treatments 31 dropped out). Frontal function, demoralization, depression, craving three time points...

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Gap junction protein beta 2 ( GJB2 ) p.V37I mutations are the most important hereditary cause of sensorineural hearing loss (SNHL) in Taiwan. Hearing outcomes associated with levels at baseline and duration follow-up. However, audiological features adult population unknown. The objectives present study were to investigate features, progression rate, allele frequency among an Taiwanese population.Subjects this case-control chosen from 13,580 participants Taiwan Precision Medicine Initiative....

1. United Nations Office on Drugs and Crime. Special Points of Interest: World Drug Report 2023. Accessed April 14, 2024. https://www.unodc.org/res/WDR-... Google Scholar

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