A5039602629- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Diabetes Treatment and Management
- Silicon Nanostructures and Photoluminescence
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Pancreatic function and diabetes
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Nanowire Synthesis and Applications
- Microbial metabolism and enzyme function
- Carbon and Quantum Dots Applications
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Infant Nutrition and Health
- Conducting polymers and applications
- 3D Printing in Biomedical Research
- Porphyrin Metabolism and Disorders
- Global Health and Surgery
- Global Public Health Policies and Epidemiology
- Renal Diseases and Glomerulopathies
- Antimicrobial Peptides and Activities
- Wound Healing and Treatments
- Advancements in Transdermal Drug Delivery
Research Institute for Bioscience and Biotechnology
2023-2025
Boston University
2023
UCLouvain
2017-2021
Solvay (Belgium)
2017-2021
University of Helsinki
2014-2017
University of Copenhagen
2016
During the last decades, advanced oral delivery systems to enhance intestinal absorption of widely applicable proteins and peptides, particularly insulin, have been developed. Here, chitosan‐conjugated undecylenic acid‐modified thermally hydrocarbonized porous silicon nanoparticles (CSUn NPs) are used, which promote mucoadhesion cellular interactions, thus boosting permeability insulin. Then, further potentiate enhancement chitosan‐modified NPs, surface NPs is modified with either l...
Multifunctional tailorable composite systems, specifically designed for oral dual-delivery of a peptide (glucagon-like peptide-1) and an enzymatic inhibitor (dipeptidyl peptidase 4 (DPP4)), were assembled through the microfluidics technique. Both drugs coloaded into these systems synergistic therapeutic effect. The composed chitosan cell-penetrating modified poly(lactide-co-glycolide) porous silicon nanoparticles as nanomatrices, further encapsulated in enteric hydroxypropylmethylcellulose...
Oral delivery of proteins is still a challenge in the pharmaceutical field. Nanoparticles are among most promising carrier systems for oral by increasing their bioavailability. However, existent data regarding nanosystems protein from vitro studies, lacking vivo experiments to evaluate efficacy these systems. Herein, multifunctional composite system, tailored droplet microfluidics, was used dual glucagon like peptide-1 (GLP-1) and dipeptidyl peptidase-4 inhibitor (iDPP4) vivo. GLP-1 with...
The conversion of aqueous dispersion nanostructured lipid carriers (NLCs) into dry powder by spray drying could be a useful approach to render NLCs with better physical chemical stability than the dispersion. In this study, NLC containing fenofibrate was converted dry, easily reconstitutable using drying. A central composite face centered design (CCFD) used investigate influence ratio protectant (mannitol and trehalose) crystallinity spray-dried on particle size, yield residual moisture...
Nanoparticulate based drug delivery systems have been extensively studied to efficiently encapsulate and deliver peptides orally. However, most of the existing data mainly focus on nanoparticles as a carrier, but ability having biological effect has not exploited. Herein, we hypothesize that nanostructured lipid carriers (NLCs) could activate endogenous glucagon-like peptide-1 (GLP-1) secretion also act oral for GLP-1 analogs (exenatide liraglutide). NLCs effectively encapsulated peptides,...
The effect of adsorption and confinement on ibuprofen was studied by immersion loading the molecules into porous silicon (PSi) microparticles. PSi microparticles were modified thermally oxidized (TOPSi) hydrocarbonized (THCPSi) to evaluate effects solvent surface chemistry obtainable drug payloads. payloads, location, molecular state adsorbed evaluated using thermal analysis. results showed that after ∼800 mg/cm3 (wdrug/vpores) mesopores, depending used in immersion, began rapidly...
Abstract The potential of nanoemulsions for the oral administration peptides is still in its early stage. aim present work was to rationally design, develop, and fully characterize a new nanoemulsion (NE) intended hydrophobically modified insulin (HM-insulin). Specific components NE were selected based on their enhancing permeation properties as well ability improve association efficiency (Miglyol 812, sodium taurocholate), stability intestinal fluids, mucodiffusion (PEGylated phospholipids...
The Fifth International Conference on Bioscience and Biotechnology, 2024 (ICBB-2024), held in Godawari, Nepal, from 21 to 24 April 2024, aimed address planetary health challenges within the local context of Nepal while fostering global dialogue. Bringing together 240 participants 10 countries, including 20 international invited speakers, conference sought explore intersections human health, environmental sustainability, societal well-being. Jointly organized by Research Institute for...
A polymeric gum has been developed herein, which combines high stretchability and self-healing capacity with a bioactivity that can target eliminate bacterial infections inflammations.
Oral cancer is primarily squamous-cell carcinoma with a 5-year survival rate of approximately 50%. Lysyl oxidase (LOX) participates in collagen and elastin maturation. The propeptide LOX released as an 18 kDa protein (LOX-PP) the extracellular environment by procollagen C-proteinases has tumor-inhibitory properties. A polymorphism region (rs1800449, G473A) results single amino acid substitution Gln for Arg. Here we investigated frequency rs1800449 OSCC employing TCGA database resources...