A5031103901- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Genetics, Bioinformatics, and Biomedical Research
- Colorectal Cancer Screening and Detection
- Medical Coding and Health Information
- Cancer Mechanisms and Therapy
- Brain Tumor Detection and Classification
- Cancer-related Molecular Pathways
- Oral Health Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Autopsy Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Cervical Cancer and HPV Research
- Biomedical and Engineering Education
- Prostate Cancer Diagnosis and Treatment
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Brain Metastases and Treatment
- Biotechnology and Related Fields
- MicroRNA in disease regulation
- Advances in Oncology and Radiotherapy
- Cancer and Skin Lesions
Mayo Clinic
2023-2025
Lagos University Teaching Hospital
2019-2024
Mayo Clinic in Arizona
2023-2024
Stellenbosch University
2023
Mayo Clinic in Florida
2023
Abstract Background The ataxia telangiectasia mutated (ATM) protein coordinates the cellular response to therapeutic radiation, and ATM inhibitors can potentially enhance efficacy of radiation in otherwise radiation-resistant tumors. Methods small molecule kinase inhibitor WSD0628 was specifically designed for enhanced distribution across blood brain barrier more effectively treat glioblastoma (GBM) metastases combination with therapy (RT). GBM metastasis patient-derived xenograft (PDX)...
Abstract Background The optimal diagnosis and management of patients with brain tumors currently uses the 2021 WHO integrated histomorphologic molecular features. However, neuro-oncology practice in resource-limited settings usually relies solely on histomorphology. This study aimed to classify glioma cases diagnosed Department Anatomic Molecular Pathology, Lagos University Teaching Hospital, using CNS tumor classification. Methods Fifty-six from 55 between 2013 were reevaluated for...
Abstract Background Brain tumors represent a significant global health challenge, with rising incidence and mortality impacting individuals worldwide contributing to cancer-related morbidity mortality. In Africa, this burden is exacerbated by limited access advanced diagnostics, treatment options, multidisciplinary care, compounded the absence of standardized cancer registration tumor biobanking. The introduction molecular as outlined in 2021 World Health Organization central nervous system...
Background: The most common intracranial neoplasm worldwide is meningioma, followed by gliomas, and then pituitary adenomas. There are geographical differences in the pattern of occurrence neoplasms. purpose this study to establish different histological types neoplasms with their age sex distributions our environment – Lagos, Nigeria.The patterns, age, gender all diagnosed within period at Department Anatomic Molecular Pathology, LUTH, Nigeria were noted analysed SPSS version 23.
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Abstract INTRODUCTION Brain tumors constitute significant morbidity and mortality in sub-Saharan Africa (SSA). Improvements neuro-oncology practice research have seen increased diagnosis of brain tumors. However, to our knowledge, there been no previous projects on tumor genetics SSA. To understand the feasibility developing biobanking registries, this project aims start by mapping out current capacity terms workforce available services. METHODOLOGY We will conduct a descriptive...
Abstract Brain tumors constitute significant morbidity and mortality in sub-Saharan Africa (SSA). There is no previous large-scale effort focusing on brain tumor genetics SSA. This project aims to map out the current neuro-oncology capacity terms of workforce available services an ongoing online survey among a cross section practitioners spread across SSA countries capture information distribution, number care practitioners, for neuropathology molecular diagnosis, management tumors, cancer...
Abstract Histologic features, presence of CDKN2A/B homozygous deletion and methylation subtype are strong determinants outcome therapy in IDH-mutant gliomas. We were interested learning if there additional markers these tumors. To address this question, we assembled a cohort 963 gliomas with overall survival data (median follow-up alive 2.7 years, median deceased 3.9 years). Array-based copy number data, targeted NGS, germline genotyping Illumina EPIC array available on 872, 226, 542, 401...
Background: Colorectal carcinoma (CRC) is the most common gastrointestinal malignancy in Nigeria with a dismal 5-year survival rate. Interactions between CD8+ T-lymphocytes and immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) programmed death-ligand 1 (PD-L1) expressions are important. Novel antibodies have been developed against these found to improve clinical outcome many solid organ malignancies. Aim: We aimed determine immunohistochemical expression of PD-L1 resected...
Background and Objectives: Studies of colorectal cancer (CRC) molecular heterogeneity have used genome-wide gene expression-based data to group patients into four consensus subtypes (CMS), but the cost sophistication analysis has limited its clinical application. This study aimed at using immunohistochemistry (IHC) classify CRC specimens in a cohort Lagos University Teaching Hospital. Materials Methods: Tissue microarrays were constructed from 75 FFPE tissue blocks CRC. These stained for...
Abstract Introduction Death from colorectal cancer is still a major concern in low- and middle-income countries. According to GLOBOCAN 2018 report, 1,096,601 new cases of were reported worldwide about 551,269 would die the disease process. Colorectal fifth most common accounts for 5.8% all seen annually Nigeria. It has been shown incontrovertibly that neoplastic polyps are precursors adenocarcinomas, even though rate lower among blacks. The increasing awareness availability colonoscopy...
Abstract BACKGROUND The diagnosis and management of patients with brain tumors currently uses WHO defined morphologic molecular features. However, neuro-oncology practice in low resource settings relies solely on histomorphology. This study aims to reclassify glioma cases diagnosed the Department Anatomic Molecular Pathology Lagos University Teaching Hospital using 2021 classification. METHODS Fifty-six between 2013 were evaluated. Morphologic was reassessed. Five-micron sections obtained...
Abstract INTRODUCTION Brain tumors constitute significant morbidity and mortality in sub-Saharan Africa (SSA). Improvements neuro-oncology practice research have seen increased diagnosis of brain tumors. However, to our knowledge, there been no previous projects on tumor genetics SSA. To understand the feasibility developing biobanking registries, this project aims start by mapping out current capacity terms workforce available services. METHODOLOGY We will conduct a descriptive...
Abstract BACKGROUND The diagnosis and management of patients with brain tumors currently uses WHO defined morphologic molecular features. However, neuro-oncology practice in low resource settings relies on histomorphology. This study aims to reclassify glioma cases diagnosed the Department Anatomic Molecular Pathology Lagos University Teaching Hospital using 2021 classification. METHODS Fifty-six between 2013 were evaluated. Morphologic was reassessed. Five-micron sections obtained for...
Abstract INTRODUCTION Prior to 2021, (classic) glioblastoma (GBM) required absence of IDH mutation and histologic features hypercellularity, nuclear atypia, microvascular proliferation (MVP), necrosis. Absence can be a result undersampling, with molecular, radiologic, clinical consistent GBM. Accordingly, WHO 2021 defined molecular as diffuse glioma IDHwt, H3wt, one or more MVP, necrosis, TERT promoter mutation, EGFR gene amplification (EGFRamp), and/or +7/−10. We hypothesized that there is...
Abstract Introduction Prostate cancer is the second most frequent worldwide. It commonest among men in Nigeria. Gleason grading and scoring system constitute useful prognostic indicator prostate diagnosis management. Over years, it has gone through important modifications. The recent of these changes was 2014 by International Society for Urological Pathology (ISUP). WHO adopted new 2016. not as part routine reporting biopsies Lagos University Teaching Hospital (LUTH) until 2017. aim this...