A5103196190- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Radiation Effects and Dosimetry
- Head and Neck Surgical Oncology
- Radiation Therapy and Dosimetry
- Salivary Gland Tumors Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Voice and Speech Disorders
- Interpreting and Communication in Healthcare
- Boron Compounds in Chemistry
- Tracheal and airway disorders
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Cancer survivorship and care
- PARP inhibition in cancer therapy
- Reconstructive Surgery and Microvascular Techniques
- RNA Interference and Gene Delivery
- Salivary Gland Disorders and Functions
- Integrated Circuits and Semiconductor Failure Analysis
- Ear and Head Tumors
- Translation Studies and Practices
- Electron Spin Resonance Studies
- Laser Applications in Dentistry and Medicine
Mayo Clinic
2021-2025
Mayo Clinic in Arizona
2023-2025
Université Paris Cité
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
WinnMed
2023-2024
Clinique Ambroise Paré
2020
Délégation Paris 5
2015
Boehringer Ingelheim (Mexico)
2013
<p>Supplementary Figure S1 includes repeats of immunofluorescence images and an example H&E staining from untreated oral mucosa.</p>
<p>Supplementary Figure S3 shows effect of irradiating different lengths esophagus. Additionally, higher magnitude images esophageal H&E images.</p>
<p>Supplementary Figure S2 demonstrates agreement between AUC computed from simulated and measured profiles.</p>
<div>Abstract<p>Ataxia Telangiectasia–<i>mutated</i> (ATM) inhibitors are being developed as radiosensitizers to improve the antitumor effects of radiotherapy, but ATM inhibition can also radiosensitize normal tissues. Therefore, understanding elevated risk tissue toxicities is critical for radiosensitizer development. This study focused on modeling relationship between acute mucosal toxicity, radiation dose, fractionation schedule, and exposure. The inhibitor WSD0628...
<p>Supplementary Data S2: derivation of modified biologically effective dose model.</p>
<p>Supplementary Data S1: the positioning reproducibility was determined for esophagus irradiations.</p>
Radiation therapy, a standard treatment option for many cancer patients, induces DNA double strand breaks (DSBs), leading to cell death. Ataxia telangiectasia mutated (ATM) kinase is key regulator of DSB repair, and ATM inhibitors are being explored as radiosensitizers various tumors, including primary metastatic brain tumors. Efficacy tumors may be influenced by lack effective drug delivery across the blood-brain barrier (BBB). The objective this study was evaluate systemic pharmacokinetics...
Abstract Background The ataxia telangiectasia mutated (ATM) protein coordinates the cellular response to therapeutic radiation, and ATM inhibitors can potentially enhance efficacy of radiation in otherwise radiation-resistant tumors. Methods small molecule kinase inhibitor WSD0628 was specifically designed for enhanced distribution across blood brain barrier more effectively treat glioblastoma (GBM) metastases combination with therapy (RT). GBM metastasis patient-derived xenograft (PDX)...
Abstract ATM inhibitors are being developed as radiosensitizers to improve the antitumor effects of radiotherapy, but inhibition can also radiosensitize normal tissues. Therefore, understanding elevated risk for tissue toxicities is critical radiosensitizer development. This study focused on modeling relationship between acute mucosal toxicity, radiation dose, fractionation schedule, and exposure. The inhibitor WSD0628 was combined with single or fractionated doses delivered oral cavity...
The uncertainty associated with the relative biological effectiveness (RBE) in proton therapy, particularly near Bragg peak (BP), has led to shift towards biological-based treatment planning. Proton RBE recently been reported as a possible cause for brainstem necrosis pediatric patients treated therapy. Despite this, vivo studies have limited due complexity of accurate delivery and absolute dosimetry. purpose this investigation was create precise efficient method treating mouse spinal cord...
In this study, we investigated whether radiomics features from pre-treatment positron emission tomography (PET) images could be used to predict disease progression in patients with HPV-positive oropharyngeal cancer treated definitive proton or x-ray radiotherapy. Machine learning models were built using a dataset Mayo Clinic, Rochester, Minnesota (n = 72) and tested on Phoenix, Arizona 22). A total of 71 clinical considered. The Mann–Whitney U test was identify the top 2 20 that...