A5035886631- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Boron Compounds in Chemistry
- Radiation Effects in Electronics
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Advances in Oncology and Radiotherapy
- RNA Interference and Gene Delivery
- Advanced X-ray and CT Imaging
- Radiation Shielding Materials Analysis
- Electron Spin Resonance Studies
- Photoreceptor and optogenetics research
St George Hospital
2024
The University of Sydney
2021-2023
University of Wollongong
2017-2021
With more patients receiving external beam radiation therapy with protons, it becomes increasingly important to refine the clinical understanding of relative biological effectiveness (RBE) for dose delivered during treatment. Treatment planning systems used in clinics typically implement a constant RBE 1.1 proton fields irrespective their highly heterogeneous linear energy transfer (LET). Quality assurance tools that can measure characteristics and quantify or be indicative outcomes become...
A new methodology for assessing linear energy transfer (LET) and relative biological effectiveness (RBE) in proton therapy beams using thermoluminescent detectors is presented. The method based on the different LET response of two lithium fluoride (LiF:Mg,Ti LiF:Mg,Cu,P) measuring charged particles. efficiency detector types was predicted recently developed Microdosimetric d(z) Model combination with Monte Carlo code PHITS. Afterwards, calculated ratio expected correlated fluence- dose- mean...
The Centre for Medical Radiation Physics introduced the concept of Silicon On Insulator (SOI) microdosimeters with 3-Dimensional (3D) cylindrical sensitive volumes (SVs) mimicking dimensions cells in an array. Several designs high-definition 3D SVs fabricated using MEMS technology were implemented. different sizes and configurations diameters between 18 30 µm, thicknesses 2–50 µm at a pitch 50 matrices 20 × 50. segmented into sub-arrays to reduce capacitance avoid pile up high-dose rate...
The measurement of depth dose profiles for range and energy verification heavy ion beams is an important aspect quality assurance procedures therapy facilities. steep gradients in the Bragg peak region these require use detectors with high spatial resolution. aim this work to characterize a one dimensional monolithic silicon detector array called "serial Dose Magnifying Glass" (sDMG) as independent beam system used conducted therapy.The sDMG consists two linear arrays 128 sensitive volumes...
Although proton therapy has become a well-established radiation modality, continued efforts are needed to improve our understanding of the molecular and cellular mechanisms occurring during treatment. Such studies challenging, requiring many resources. The purpose this study was create phantom that would allow multiple in vitro experiments be irradiated simultaneously with spot-scanning beam.The setup included modified patient-couch top coupled high-precision robotic arm for positioning. An...
Radiation monitoring in space radiation is complex due to galactic cosmic rays (GCRs), solar particle events (SPEs), and albedo particles. Thermal neutrons are an important component the Moon field which can cause single event upset (SEU) electronics when they interact with <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> B present electronic components. In this work, we studied application of silicon on insulator (SOI) microdosimeters...
An experimental and simulation-based study was performed on a 12C ion minibeam radiation therapy (MBRT) field produced with clinical broad beam brass multi-slit collimator (MSC). Silicon-on-insulator (SOI) microdosimeters developed at the Centre for Medical Radiation Physics (CMRP) micron sized sensitive volumes were used to measure microdosimetric spectra varying positions throughout MBRT corresponding dose-mean lineal energies RBE 10% cell survival (RBE10) calculated using modified...
Abstract Proton therapy has a distinct dosimetric advantage over conventional photon due to its Bragg peak profile. This allows greater accuracy in dose delivery and conformation the target, however it requires precision setup, for quality assurance (QA) procedures. The AAPM TG 224 report recommends daily range spot position checks with tolerance on order of millimetre. Daily QA systems must therefore be efficient use capable sub-millimetre few suitable commercial are available. In this...
The uncertainty associated with the relative biological effectiveness (RBE) in proton therapy, particularly near Bragg peak (BP), has led to shift towards biological-based treatment planning. Proton RBE recently been reported as a possible cause for brainstem necrosis pediatric patients treated therapy. Despite this, vivo studies have limited due complexity of accurate delivery and absolute dosimetry. purpose this investigation was create precise efficient method treating mouse spinal cord...
Fixed-gantry radiation therapy has been proposed as a low-cost alternative to the conventional rotating-gantry therapy, that may help meet rising global treatment demand. systems require gravitational motion compensated reconstruction algorithms produce cone-beam CT (CBCT) images of sufficient quality for image guidance. The aim this work was adapt and investigate five CBCT fixed-gantry images. investigated were Feldkamp-Davis-Kress (FDK), prior constrained compressed sensing (PICCS), FDK...
Abstract Purpose . A radiotherapy system with a fixed treatment beam and rotating patient positioning could be smaller, more robust cost effective compared to conventional gantry systems. However, rotation cause anatomical deformation compromise delivery. In this work, we demonstrate an image-guided workflow prototype that accounts for during maintain dosimetric accuracy. Methods The consists of Elekta Synergy linac the therapy orientated downward custom-built (PRS). phantom deforms was...
Abstract Background This paper describes the protocol for Nano X Image Guidance (Nano IG) trial, a single-institution, clinical imaging study. The is prototype fixed-beam radiotherapy system developed to investigate feasibility of low-cost, compact increase global access radiation therapy. study aims assess volumetric image guidance with cone beam computed tomography (CBCT) acquired during horizontal patient rotation on system. Methods In IG study, we will determine whether can be performed...
Abstract BackgroundThis paper describes the protocol for Nano X Image Guidance (Nano IG), a single-institution, clinical imaging study. The is prototype fixed-beam radiotherapy system developed to investigate feasibility of low cost, compact increase global access radiation therapy. This study aims assess volumetric image guidance with Cone Beam Computed Tomography (CBCT) acquired during horizontal patient rotation on system.MethodsIn IG we will determine whether can be performed system,...