A5059956215- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Drug Transport and Resistance Mechanisms
- Blood groups and transfusion
- Urinary Bladder and Prostate Research
- Cholesterol and Lipid Metabolism
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
- Child Abuse and Related Trauma
- Infectious Diseases and Tuberculosis
- Cardiovascular Syncope and Autonomic Disorders
- Immunodeficiency and Autoimmune Disorders
- Autopsy Techniques and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Leprosy Research and Treatment
- Traumatic Brain Injury Research
- Hormonal Regulation and Hypertension
- Genomics and Rare Diseases
- Social and Cultural Dynamics
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Blood disorders and treatments
- Pregnancy and preeclampsia studies
- Venous Thromboembolism Diagnosis and Management
- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
University of Saskatchewan
2016-2024
University of Calgary
2021
Palmetto Hematology Oncology
2020
University of British Columbia
2012-2014
Traumatic brain injury (TBI) increases Alzheimer's disease (AD) risk and leads to the deposition of neurofibrillary tangles amyloid deposits similar those found in AD. Agonists Liver X receptors (LXRs), which regulate expression many genes involved lipid homeostasis inflammation, improve cognition reduce neuropathology AD mice. One pathway by LXR agonists exert their beneficial effects is through ATP-binding cassette transporter A1 (ABCA1)-mediated transport onto apolipoprotein E (apoE). To...
Background. In the fall of 2014, a North American outbreak enterovirus D68 resulted in significant number pediatric hospital admissions for respiratory illness throughout America. This study characterized clinical presentation and risk factors severe course children admitted to British Columbia Children's Hospital during 2014 outbreak. Methods. Retrospective chart review patients with confirmed EV-D68 infection BCCH symptoms 2014. Past medical history, presentation, management, was collected...
A careful review of hematological data obtained for patients with relatively mild hemolytic anemia may result in the detection silent hemoglobin (Hb) variants that exhibit significant instability when tested appropriate laboratory procedures. This was case A.S., a 27-year-old Spanish female who had splenomegaly and
Protein C is a circulating anticoagulant that inhibits factor Va and VIIIa promotes fibrinolysis. Compound heterozygous or homozygous variants in the gene (PROC) lead to severe deficiency of protein affected neonates typically present shortly after birth with purpura fulminans. We describe an infant who suffered diffuse intracranial hemorrhage as neonate presented fulminans older which led investigations were consistent deficiency. demonstrate subacute findings on neuroimaging suggest this...
We describe two unrelated patients, both heterozygous for an unstable hemoglobin (Hb) variant named Hb Calgary (HBB: c.194G>T) that causes severe hemolytic anemia and dyserythorpoietic, resulting in transfusion dependence iron overload. The molecular pathogenesis is a missense variation on the β-globin gene, presumed to lead Hb. phenotype of particularly presenting as transfusion-dependent early infancy, precluding phenotypic diagnosis highlighting importance genetic testing order make...
Traumatic brain injury (TBI) is a major environmental risk factor for Alzheimer's disease (AD). TBI leads to the formation of neurofibrillary tangles and in, approximately 30% subjects, amyloid deposits similar those found in AD. Apolipoprotein E (apoE) lipid carrier best-established genetic ApoE genotype also influences recovery after TBI. receives lipids from ATP-binding cassette transporter A1 (ABCA1) lipidated apoE facilitates beta (Aβ) clearance. Agonists Liver X Receptors (LXR) induce...