A5018825101- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Spinal Hematomas and Complications
- Systemic Sclerosis and Related Diseases
- Colorectal Cancer Screening and Detection
- Growth Hormone and Insulin-like Growth Factors
- Tracheal and airway disorders
- S100 Proteins and Annexins
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular and Diving-Related Complications
- Metabolomics and Mass Spectrometry Studies
- Vascular Anomalies and Treatments
- Fetal and Pediatric Neurological Disorders
- Pituitary Gland Disorders and Treatments
- Cancer Genomics and Diagnostics
- Ophthalmology and Eye Disorders
- Spinal Dysraphism and Malformations
- Cancer, Hypoxia, and Metabolism
- Advanced Proteomics Techniques and Applications
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Computational Drug Discovery Methods
Hopital Universitaire Habib Bourguiba
2023-2024
University of Sfax
2018-2024
Hopitaux Civils de Colmar
2020
Faculté de médecine de Tunis
2016
Tunis University
2016
Tunis El Manar University
2016
Pesticides are widely used, resulting in continuing human exposure with potential health impacts. Some exposures related to agricultural works have been associated neurological disorders. Since the 2000s, hypothesis of role pesticides occurrence central nervous system (CNS) tumors has better documented literature. However, etiology childhood brain cancers still remains largely unknown. The major objective this work was assess pesticide as a risk factor for CNS based on questionnaires and...
High-grade gliomas represent the most common group of infiltrative primary brain tumors in adults associated with high invasiveness, agressivity, and resistance to therapy, which highlights need develop potent drugs novel mechanisms action. The aim this study is reveal changes proteome profiles under stressful conditions identify prognostic biomarkers altered apoptogenic pathways involved anticancer action human isocitrate dehydrogenase (IDH) mutant high-grade gliomas. Our protocol consists...
<h3>ABSTRACT</h3> <h3>Background:</h3> Facet osteosynthesis can be performed to treat facet syndrome (FS) and reduce spinal instability following laminectomy in patients with lumbar stenosis (LSS). The present study evaluated clinical radiological outcomes the FFX device. <h3>Methods:</h3> Patients FS or LSS were prospectively enrolled a single-arm, multicenter study. device was placed at affected levels without concomitant posterior interbody fusion (PLIF) procedures. visual analog scale...
Pesticides are increasingly used in combinations crop protection, resulting enhanced toxicities for various organisms. Although protein adductomics is challenging, it remains a powerful bioanalytical tool to check environmental exposure and characterize xenobiotic adducts as putative toxicity biomarkers with high accuracy, facilitated by recent advances proteomic methodologies mass spectrometry high-throughput technique. The present study aims predict the potential neurotoxicity effect of...
The widespread use of pesticides, particularly in combinations, has resulted enhanced hazardous health effects. However, little is known about their molecular mechanism interactions. aim this study was to assess the neurotoxicity effect pesticides mixtures by adopting a 3D vitro developed neurospheroid model, followed treatment increased concentrations for 24 h and analysis shotgun proteomic-based approach with high-resolution tandem mass spectrometry. Three proteins, namely,...