A5046558939- Brucella: diagnosis, epidemiology, treatment
- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Protein Degradation and Inhibitors
- Urinary Tract Infections Management
- Burkholderia infections and melioidosis
- Essential Oils and Antimicrobial Activity
- Traditional Chinese Medicine Analysis
- Antibiotics Pharmacokinetics and Efficacy
- Sinusitis and nasal conditions
- Antimicrobial Resistance in Staphylococcus
- Liver Disease Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Streptococcal Infections and Treatments
- Dermatological and COVID-19 studies
- Hepatitis C virus research
- Multiple Myeloma Research and Treatments
- Diagnosis and treatment of tuberculosis
- Histone Deacetylase Inhibitors Research
- Leptospirosis research and findings
- Orthopedic Surgery and Rehabilitation
- Listeria monocytogenes in Food Safety
- Infection Control and Ventilation
- SARS-CoV-2 and COVID-19 Research
Süleyman Demirel University
2011-2024
Suleyman Demirel University
2011-2024
Boehringer Ingelheim (Austria)
2015-2024
Gaziantep Children's Hospital
2024
Erasmus MC
2024
Adli Tıp Kurumu
2022
Sağlık Bilimleri Üniversitesi
2020
Erciyes University
2017-2018
Office of Infectious Diseases
2015
Suleyman Demirel University Research and Education Hospital
2010
Bromodomain and extra-terminal (BET) protein inhibitors have been reported as treatment options for acute myeloid leukemia (AML) in preclinical models are currently being evaluated clinical trials. This work presents a novel potent selective BET inhibitor (BI 894999), which has recently entered trials (NCT02516553). In studies, this compound is highly active AML cell lines, primary patient samples, xenografts. HEXIM1 described an excellent pharmacodynamic biomarker target engagement tumors...
This study was planned to determine the risk factors of candidemia, and most common Candida species causing bloodstream infections. A case-control which included adult patients conducted over a 1-year period at tertiary-care educational hospitals in Turkey. total 83 candidemia episodes were identified during period. albicans recovered (45.8%) followed by tropicalis (24.1%) parapsilosis (14.5%) glabrata isolated from only four (4.8%) patients. Presence urethral catheter (odds ratio [OR] 2.38;...
The changes in balance of cytokine profile may result either recovery or persistence hepatitis B virus (HBV) and C (HCV) infections. This study aims to reveal a possible correlation between levels, ie, tumor necrosis factor (TNF)-α; interferon-gamma (IFN-γ); interleukin (IL)-10, IL-18, transforming growth factor-beta (TGF-β); Ishak score fibrosis patients with chronic (CHB) (CHC). Fifty CHB (n=25), CHC the control group subjects negative serology (n=30) were included study. Patients who did...
To assess the antimicrobial susceptibility of Brucella melitensis strains in our region. Brucellosis is a common disease Turkey. Moreover, difficulties are encountered treatment process, such as long-lasting therapy, relapses, and side effects drugs. Hence, novel approaches current antibiotics vital. Materials methods: Thirty-four spp. isolated from blood samples patients with brucellosis were included. Minimal inhibitory concentrations for tetracycline, rifampicin, streptomycin,...
Bloodstream infection caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens has become a serious concern worldwide. The purpose of this study was to identify risk factors for bacteremia due ESBL-producing Escherichia coli in Turkish hospital.We retrospectively reviewed the medical records patients with E. tertiary care centre from January 2007 October 2011. Data such as demographic features, underlying conditions, and antibiotic exposure were analysed.A total 113 included...
Methicillin-resistant Staphylococcus aureus (MRSA) is a nosocomial pathogen that causes morbidity and mortality worldwide. The options for the treatment of MRSA infections are limited. Linezolid an antibacterial agent oxazolidinone group. It has spectrum limited to gram-positive bacteria. Tigecycline broad-spectrum antibiotic glycylcycline A total 60 strains isolated from various clinical specimens were included in study. Minimum inhibitory concentrations (MICs) determined by Etest method,...
Abstract Objective The objective of the present study was to investigate phenolic compositions, antioxidant, antimicrobial and cytotoxic activities four Astragalus species, two which are endemic Turkish flora. Methods total flavonoid contents methanol extracts obtained from species were detected using Folin-Ciocalteu aluminum chloride colorimetric assays. Their compositions identified by Liquid chromatography–mass spectrometry (LC-MS). antioxidant activity assayed with phosphomolybdenum,...
The first-line treatment for Pneumocystis jirovecii pneumonia (PCP) is trimethoprim-sulfamethoxazole (TMP-SMZ).However, some cases require alternative agents due to the side effects of TMP-SMZ.Treatment with TMP-SMZ was initiated in an HIV-positive patient microbiologically confirmed PCP, who presented acute renal failure on admission.On third day treatment, discontinued worsening function.Subsequently, clindamycin combination caspofungin.Although caspofungin-based therapies were shown be...
Transcription factors (TFs) are important mediators of aberrant transcriptional programs in cancer cells. In this study, we focus on TF activity (TFa) as a biomarker for cell-line-selective anti-proliferative effects, that high TFa predicts sensitivity to loss function given gene (i.e., genetic dependencies [GDs]). Our linear-regression-based framework identifies 3,047 pan-cancer and 3,952 cancer-type-specific candidate TFa-GD associations from cell line data, which then cross-examined...
Brucellosis is an important public health problem in the Mediterranean countries, including our country. Furthermore, because of different symptoms and clinical findings, disease could be confused with several other diseases. In this article, three unusual findings brucellosis are presented: pancytopenia, endocarditis meningitis.
FibroTest and ActiTest are noninvasive tests used in determining the level of fibrosis degree necroinflammatory activity liver. In our study, we aimed to investigate whether these could be alternative liver biopsy.Fifty patients were included study. Serum samples obtained needle biopsy was performed on same day. Levels levels ActiTest, both determined via serum biochemical markers, compared with histopathological examination. For statistical analyses, Mc Nemar chi square test Spearman's...
SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 2006 Aralik; 13(4) 2000-2004 yillari arasinda izole edilen uropatojen Escherichia coli suslarinda artan antibiyotik direnci Onur Kaya, Fusun Zeynep Akcam, Cemile Uyar, Canan Demir, Guler Yayli Ozet Uriner sistem infeksiyonlari antimikrobiyallere direnc orani ile birlikte en sik gorulen infeksiyonlar arasindadir. Bu calismanin amaci Ocak 2000 2004 uriner infeksiyonlu hastalardan izolatlarinin degisimlerini saptamaktir. Calisma retrospektif...
Brucellosis, a zoonosis that is common worldwide, endemic in many countries, primarily those of the Mediterranean region (including Turkey). Human brucellosis systemic infection with wide clinical spectrum. Although hepatic involvement very during course chronic brucellosis, abscess rare complication Brucella spp. infection. We present case caused by melitensis , which resembled presentation surgical acute abdomen.
Abstract Background: Bromodomain and extra-terminal (BET) protein inhibitors comprising the family members BRD2, 3, 4 T are being extensively studied as treatment options in human haematological malignancies well solid cancers. BRD4 is a key epigenetic regulator playing an important role activating p-TEFb governing expression of various oncogenes including MYC by contributing to multi-protein complexes forming so-called super-enhancers. BI 894999 novel, potent selective orally bioavailable...