A5083514129- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Eosinophilic Esophagitis
- Animal Virus Infections Studies
- Pancreatitis Pathology and Treatment
- Genomics and Chromatin Dynamics
- Nanoplatforms for cancer theranostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- Phagocytosis and Immune Regulation
- Sarcoidosis and Beryllium Toxicity Research
- RNA modifications and cancer
- interferon and immune responses
- Immune Response and Inflammation
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Immune cells in cancer
Southern Medical University Shenzhen Hospital
2025
Tsinghua University
2016-2024
Center for Life Sciences
2016-2024
King Center
2023
Significance Pulmonary fibrosis is a common final outcome of many lung diseases, and its occurrence may be closely associated with the disturbance homeostasis alterations in pulmonary function. In this study, we identified leucine-rich repeat kinase 2 (LRRK2) as pivotal molecule alveolar type II epithelial (AT2)–coordinated responses context bleomycin-induced fibrosis. Our results demonstrated that LRRK2 restrained progressive by preventing AT2 cell dysfunction subsequent CCL2/CCR2...
Dendritic cells (DCs), the key antigen-presenting cells, are primary regulators of immune responses. Transcriptional regulation DC development had been one major research interests in biology; however, epigenetic regulatory mechanisms during remains unclear. Here, we report that Histone deacetylase 3 (Hdac3), an important regulator, is highly expressed pDCs, and its deficiency profoundly impaired pDCs. Significant disturbance homeostasis hematopoietic progenitors was also observed...
Innovations on materials and technologies have greatly promoted the rapid development of wearable electronics from disease diagnosis to therapeutics. For superficial skin tumors, skin-attachable patches possess advantages minimally invasive property, alleviative side effects, high efficiency. The noninvasive techniques devices is still in urgent demands. Here, a flexible patch fabricated through facile preparation method reported for hybrid thermophysical therapy adaptative immune function...
Dendritic Cells (DCs) are highly specialized antigen presenting cells that play crucial roles in innate and adaptive immunity. Previous studies suggested Toll-like receptor (TLR) agonists could be used as potential adjuvants, activation of TLRs can boost DC-induced immune responses. TLR2 have been shown to enhance DC-mediated However, classical such Pam3CSK4 not stable enough vivo, which limits their clinical applications. In this study, a novel structurally agonist named SUP3 was designed....
The development of distinct dendritic cell (DC) subsets, namely, plasmacytoid DCs (pDCs) and conventional DC subsets (cDC1s cDC2s), is controlled by specific transcription factors. IRF8 essential for the fate specification cDC1s. However, how expression Irf8 regulated not fully understood. In this study, we identified TRIM33 as a critical regulator differentiation maintenance. deletion in Trim33fl/fl Cre-ERT2 mice significantly impaired from hematopoietic progenitors at different...
The helper-like ILC contains various functional subsets, such as ILC1, ILC2, ILC3 and LTi cells, mediating the immune responses against viruses, parasites, extracellular bacteria, respectively. Among them, cells are also crucial for formation of peripheral lymphoid tissues, lymph nodes. Our research, along with others', indicates a high proportion in fetal pool, which significantly decreases after birth. Conversely, non-LTi ILCs increases postnatally, corresponding to need mediate tissue...
Building a simple and efficient in vitro differentiation system is crucial for studying the regulatory mechanisms during development of innate lymphoid cells (ILCs). Here, we present protocol generating ILC subsets from α4β7+ progenitors (αLPs). We describe steps murine cell isolation fetal liver adult bone marrow, flow cytometry sorting αLPs, culture. then detail procedures analysis ILCs. This significantly simplifies process through vitro. For complete details on use execution this...
Abstract Dendritic cells (DCs), the key antigen-presenting cells, are primary regulators of immune responses. Transcriptional regulation DC development had been one major research interests in biology, however, epigenetic regulatory mechanisms during remains unclear. Here, we report that Histone deacetylase 3 ( Hdac3 ), an important regulator, is highly expressed pDCs, and its deficiency profoundly impaired pDCs. Significant disturbance homeostasis hematopoietic progenitors was also observed...
SUMMARY Innate lymphoid cells (ILCs) are crucial for maintaining tissue homeostasis. The dynamic composition of ILC subsets during ontogeny has been observed over a decade, yet the underlying mechanisms remain incompletely understood. Here, we combined differentiation assay and scRNA-seq analysis to compare fetal adult development, assessed their contribution change subsets. We revealed preference LTi cell in hematopoietic progenitors, contrasted with non-LTi bias stages. Our analyses...