A5102926242- Immune cells in cancer
- Immune Response and Inflammation
- Genomics, phytochemicals, and oxidative stress
- IL-33, ST2, and ILC Pathways
- Medicinal Plants and Bioactive Compounds
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Phagocytosis and Immune Regulation
- Complement system in diseases
- Chronic Kidney Disease and Diabetes
- Acupuncture Treatment Research Studies
- NF-κB Signaling Pathways
- Phytochemicals and Antioxidant Activities
- Herpesvirus Infections and Treatments
- Inflammation biomarkers and pathways
- Phytochemistry and Biological Activities
- Long-Term Effects of COVID-19
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Liver physiology and pathology
- Immunotherapy and Immune Responses
- Renal and related cancers
Ruijin Hospital
2015-2025
Shanghai Jiao Tong University
2015-2025
Tsinghua University
2021-2024
Chengdu University of Traditional Chinese Medicine
2023-2024
University of Chinese Academy of Sciences
2018
Center for Excellence in Molecular Cell Science
2018
Renal fibrosis is widely considered a common mechanism leading to end-stage renal failure. Epithelial-to-mesenchymal transition (EMT) plays important roles in the pathogenesis of fibrosis. Runt-related transcription factor 1(RUNX1) vital role hematopoiesis via Endothelial-to-Hematopoietic Transition (EHT), process that conceptually similar EMT, but its EMT and unclear. Here, we demonstrate RUNX1 overexpressed processes TGF-β-induced partial expression level SMAD3-dependent. Knockdown...
Sepsis is a high-mortality disease without effective therapeutic options. The hyperactivation of the monocyte-macrophage system, especially M1 macrophages, triggers onset septic shock. Gentiopicroside (GENT), main active component in traditional Chinese medicinal herb Radix Gentianae, has been shown to have anti-inflammatory properties. Nevertheless, this effect not fully elucidated.In vitro, we stimulated primary bone marrow-derived macrophages (BMMs) or peritoneal elucidated (PEMs) by...
The helper-like ILC contains various functional subsets, such as ILC1, ILC2, ILC3 and LTi cells, mediating the immune responses against viruses, parasites, extracellular bacteria, respectively. Among them, cells are also crucial for formation of peripheral lymphoid tissues, lymph nodes. Our research, along with others', indicates a high proportion in fetal pool, which significantly decreases after birth. Conversely, non-LTi ILCs increases postnatally, corresponding to need mediate tissue...
Summary Podocytes, the main target of immune complex, participate actively in development glomerular injury as cells. Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate molecular that has recognition function, and involved mediation cell immunoregulation. Here we explored expression DC-SIGN on podocytes its role inflammatory responses lupus nephritis (LN). Expression immunoglobulin (Ig)G1 was observed glomeruli LN patients. co-expressed...
The development of distinct dendritic cell (DC) subsets, namely, plasmacytoid DCs (pDCs) and conventional DC subsets (cDC1s cDC2s), is controlled by specific transcription factors. IRF8 essential for the fate specification cDC1s. However, how expression Irf8 regulated not fully understood. In this study, we identified TRIM33 as a critical regulator differentiation maintenance. deletion in Trim33fl/fl Cre-ERT2 mice significantly impaired from hematopoietic progenitors at different...
Abstract Alveolar macrophages (AMs) are the primary lung-resident that play a pivotal role in pathogen clearance and surfactant homeostasis. The precise molecular mechanisms maintaining AM homeostasis remain incompletely understood. Histone deacetylase (HDAC) 1 2 pleiotropic enzymes removing acetyl moieties from histone proteins, facilitating transcriptional repression via chromatin condensation. Hdac1 Hdac2 exhibit broad tissue distribution modulate various cellular processes across...
With the rapid global spread of COVID-19, it has become evident that virus can lead to multisystem complications, leading a significant increase in related publications. Bibliometrics serves as valuable tool for identifying highly cited literature and research hotspots within specific areas.
Chronic obstructive pulmonary disease (COPD) is a major public health problem. Due to the restriction of expiratory airflow, it characterized by emphysematous destruction lungs. Shortness breath one main clinical symptoms. Auricular acupressure therapy characteristic Chinese medicine that treats compressing ear points. Usually, seeds Vaccaria segetalis are used stimulate points, which has effect regulating qi and alleviating wheezing. In this paper, we propose traditional (TCM) for symptoms...
Chronic obstructive pulmonary disease (COPD) is a major public health problem. Due to the restriction of expiratory airflow, it characterized by emphysematous destruction lungs. Shortness breath one main clinical symptoms. Auricular acupressure therapy characteristic Chinese medicine that treats compressing ear points. Usually, seeds Vaccaria segetalis are used stimulate points, which has effect regulating qi and alleviating wheezing. In this paper, we propose traditional (TCM) for symptoms...
SUMMARY Innate lymphoid cells (ILCs) are crucial for maintaining tissue homeostasis. The dynamic composition of ILC subsets during ontogeny has been observed over a decade, yet the underlying mechanisms remain incompletely understood. Here, we combined differentiation assay and scRNA-seq analysis to compare fetal adult development, assessed their contribution change subsets. We revealed preference LTi cell in hematopoietic progenitors, contrasted with non-LTi bias stages. Our analyses...