A5011689299- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Neurotransmitter Receptor Influence on Behavior
- Ubiquitin and proteasome pathways
- Genetic Syndromes and Imprinting
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Bipolar Disorder and Treatment
- Histone Deacetylase Inhibitors Research
- Medicinal Plant Pharmacodynamics Research
- Neuroscience and Neuropharmacology Research
- Macrophage Migration Inhibitory Factor
- Tryptophan and brain disorders
- Axon Guidance and Neuronal Signaling
- Protein Kinase Regulation and GTPase Signaling
- Prion Diseases and Protein Misfolding
- Glioma Diagnosis and Treatment
- Signaling Pathways in Disease
- Kruppel-like factors research
- Peptidase Inhibition and Analysis
- Amino Acid Enzymes and Metabolism
- Plant chemical constituents analysis
- Biomedical Research and Pathophysiology
University of Campania "Luigi Vanvitelli"
2016-2025
Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli
2024
Institute of Genetics and Biophysics
2004-2012
Waters (United States)
2008
Institute for Experimental Endocrinology and Oncology
2003-2004
Despite extensive efforts to develop new treatments, the prognosis for glioblastoma multiforme (GBM) is extremely unfavorable, urging identification of chemotherapeutics. A previous work identified cyclic decapeptide uPAcyclin as a potent inhibitor GBM cell migration, matrix invasion and vascular-like structures' formation, acting through binding αV integrins not interfering with proliferation or survival. These clearcut activities prompted us design test novel derivatives on cultured U87-MG...
Glioblastoma multiforme is a highly aggressive brain tumor whose prognosis very poor. Due to early invasion of parenchyma, its complete surgical removal nearly impossible, and even after combined treatment (association surgery chemo- radio-therapy) five-year survival only about 10%. Natural products are sources novel compounds endowed with therapeutic properties in many human diseases, including cancer. Here, we report that the water extract Ruta graveolens L., commonly known as rue, induces...
Glioblastoma (GBM), a high-grade glioma (WHO grade IV), is the most aggressive form of brain cancer. Available treatment options for GBM involve combination surgery, radiation and chemotherapy but result in poor survival outcome. high-vascularized tumor antiangiogenic drugs are widely used therapy as adjuvants to control abnormal vasculature. Vasculogenic mimicry occurs an alternative vascularization mechanism, providing means whereby can escape anti-angiogenic therapies. Here, using vitro...
Angiogenesis is a phenomenon that includes different processes, such as endothelial cell proliferation, differentiation, and migration, lead to the formation of new blood vessels involve several signal transduction pathways. Here we show tube assay simple in vitro method evaluate impact natural products on angiogenesis investigate molecular mechanisms involved. In particular, presence water extract Ruta graveolens (RGWE), cells are no longer able form cell-cell network RGWE effects human...
Serotonin (5-HT) is a neurotransmitter involved in many aspects of the neuronal function. The synthesis 5-HT initiated by hydroxylation tryptophan, catalyzed tryptophan hydroxylase (TPH). Two isoforms TPH (TPH1 and TPH2) have been identified, with TPH2 almost exclusively expressed brain. Following discovery, it was reported that polymorphisms both gene non-coding regions are associated spectrum psychiatric disorders. Thus, insights into mechanisms specifically regulate expression its...
We performed ultra-deep methylation analysis at single molecule level of the promoter region developmentally regulated D-Aspartate oxidase (Ddo), as a model gene, during brain development and embryonic stem cell neural differentiation. Single enabled us to establish effective epiallele composition within mixed or pure populations. In this framework, an is defined specific combination methylated CpG Ddo locus can represent epigenetic haplotype revealing cell-to-cell heterogeneity. Using...
Chemokines and cytokines, primarily known for their roles in the immune inflammatory response, have also been identified as key components of neurogenic niche where they are involved modulation neural stem cell proliferation differentiation. However, a complete understanding functional role played differentiation comprehensive profiling these secreted molecules lacking. By exploiting multiplexing capability magnetic bead-based immunoassays, we investigated changes expression levels set...
The limited therapeutic options for ischemic stroke treatment render necessary the identification of new strategies. In recent years, it has been shown that natural compounds may represent a valid opportunity. Therefore, present study aimed to evaluate protective effect Ruta graveolens water extract (RGWE) in an vivo experimental model brain ischemia.RGWE effects on damage and neurological function were evaluated adult rats subjected transient occlusion Middle Cerebral Artery (tMCAO),...
Glioblastoma (GBM) is the most aggressive type of brain tumor, characterized by poor outcome and limited therapeutic options. During tumor progression, GBM may undergo process vasculogenic mimicry (VM), consisting formation vascular-like structures which further promote aggressiveness malignancy. The resulting resistance to anti-angiogenetic therapies urges identification new compounds targeting VM. Extracts natural plants represent potential tools. Among these, components
Abstract The transcription factor/nuclear receptor Nurr1 is essential for the differentiation of midbrain dopaminergic neurones. Here we demonstrate that, during ontogeny rat ventral mesencephalon, nurr1 gene expression developmentally regulated and its levels show a sharp peak between embryonic day E13 E15, when most neurones differentiate. In addition, in primary cultures from follows temporal pattern comparable to that observed vivo . We also report exposure mesencephalic depolarizing...
Tau is a multifunctional protein detected in different cellular compartments neuronal and non-neuronal cells. When hyperphosphorylated aggregated atrophic neurons, tau considered the culprit for death familial sporadic tauopathies. With regards to Alzheimer's disease (AD) pathogenesis, it not yet established whether entangled represents cause or consequence of neurodegeneration. In fact, unquestionably accepted that amyloid-β precursor (AβPP) plays pivotal role genesis disease, postulated...