A5078755602- Advanced Glycation End Products research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Research and Treatments
- FOXO transcription factor regulation
- Biochemical effects in animals
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- TGF-β signaling in diseases
- Head and Neck Cancer Studies
- Histone Deacetylase Inhibitors Research
- Cervical Cancer and HPV Research
- Adipose Tissue and Metabolism
- Food Quality and Safety Studies
- Education, sociology, and vocational training
- French Language Learning Methods
- Viral-associated cancers and disorders
- Colorectal Cancer Treatments and Studies
- Bone Metabolism and Diseases
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
University of Liège
2017-2023
University of Mons
2016-2018
Abstract Metabolic reprogramming toward aerobic glycolysis unavoidably favours methylglyoxal (MG) and advanced glycation end products (AGEs) formation in cancer cells. MG was initially considered a highly cytotoxic molecule with potential anti-cancer value. However, we have recently demonstrated that enhanced tumour growth metastasis. In an attempt to understand this dual role, explored MG-mediated dicarbonyl stress status four breast glioblastoma cell lines relation their glycolytic...
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly malignancy with no efficient therapy available up‐to‐date. Glycolysis is the main provider of energetic substrates to sustain cancer dissemination PDAC. Accordingly, altering glycolytic pathway foreseen as sound approach trigger pancreatic regression. Here, we show for first time that high transforming growth factor beta‐induced (TGFBI) expression in PDAC patients associated poor outcome. We demonstrate that, although usually secreted...
// Imelda Seminerio 1 , Nadège Kindt Géraldine Descamps Justine Bellier 1, 5 Jérôme R. Lechien Quentin Mat Charles Pottier 2 Fabrice Journé 3 and Sven Saussez 4 Department of Human Anatomy Experimental Oncology, Research Institute for Health Sciences Technology, Faculty Medicine Pharmacy, University Mons, Mons B-7000, Belgium Pathology, C.H.U., SART TILMAN, Liège, Liège 4000, Laboratory Oncology Surgery, Jules Bordet Institute,...
Elevated aerobic glycolysis rate is a biochemical alteration associated with malignant transformation and cancer progression. This metabolic shift unavoidably generates methylglyoxal (MG), potent inducer of dicarbonyl stress through the formation advanced glycation end products (AGEs). We have previously shown that silencing glyoxalase 1 (GLO1), main MG detoxifying enzyme, endogenous resulting in enhanced growth metastasis vivo. However, molecular mechanisms which promotes development remain...
Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), dicarbonyl compound that is produced side product during glycolysis, highly reactive and induces the formation advanced glycation end-products are implicated in several pathologies including cancer. All mammalian have an enzymatic defense against MG composed by glyoxalases GLO1 GLO2 converts to d-lactate. Colorectal cancer (CRC) one most frequently occurring cancers with high morbidity...
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death. Therapeutic options remain very limited and are based on classical chemotherapies. Energy metabolism reprogramming appears as an emerging hallmark cancer considered a therapeutic target with considerable potential. Myoferlin, ferlin family member protein overexpressed in PDAC, involved plasma membrane biology has tumor-promoting function. In continuity our previous studies, we investigated role...
Highlights•Glycolytic mutant KRAS display higher MGO stress than wild-type CRC cells•MGO is a potent inducer of AKT signaling in induces resistance to anti-EGFR therapy setting•Carnosine, an scavenger, sensitizes tumors therapySummaryThe use cetuximab anti-epidermal growth factor receptor (anti-EGFR) antibodies has opened the era targeted and personalized colorectal cancer (CRC). Poor response rates have been unequivocally shown are even observed majority tumors. Therefore, patient selection...
Abstract Colon adenocarcinoma is the third most commonly diagnosed cancer and second deadliest one. Metabolic reprogramming, described as an emerging hallmark of malignant cells, includes predominant use glycolysis to produce energy. Recent studies demonstrated that mitochondrial electron transport chain inhibitor reduced colon tumour growth. Accumulating evidence show myoferlin, a member ferlin family, highly expressed in several types, where it acts promoter participates metabolic rewiring...
Aerobic glycolysis, also known as the Warburg effect, is predominantly upregulated in a variety of solid tumors, including breast cancer. We have previously reported that methylglyoxal (MG), very reactive by-product unexpectedly enhanced metastatic potential triple negative cancer (TNBC) cells. MG and MG-derived glycation products been associated with various diseases, such diabetes, neurodegenerative disorders, Glyoxalase 1 (GLO1) exerts an anti-glycation defense by detoxifying to...
Introduction Methylglyoxal (MG) is an endogenous dicarbonyl spontaneously produced during glycolysis able to react with proteins, lipids and DNA, inducing a carbonyl stress. Glyoxalase 1 (GLO1) detoxifies MG into D-Lactate. High notably associated diabetes cancer. Melanoma the most deadly form of skin Therapy based on inhibition MAPK pathway, often over activated. Unfortunately, BRAF MEK inhibitors are briefly efficient as tumours rapidly develop resistance mechanisms. generally highly...
Introduction Methylglyoxal (MG) is spontaneously produced during glycolysis. MG reacts with proteins, lipids and DNA, thus inducing a dicarbonyl stress. Glyoxalase 1 (GLO1) detoxifies into D-Lactate. High notably associated diabetes cancer as the latter presents deregulated energy metabolism where tumour cells use glycolysis rather than mitochondrial respiration. The impact of on ambiguous some studies reported an anti-tumour others pro-tumour effect upon GLO1 silencing. Material methods In...
Introduction Tumour cells use glycolysis rather than mitochondrial respiration to produce their energy. Methylglyoxal (MG), a highly reactive side-product of glycolysis, glycates proteins and nucleic acids thereby inducing dicarbonyl stress in cancer cells. In previous studies, we reported that the accumulation MG-protein adducts is constant feature breast colon tumours when compared with normal tissues. More recently, demonstrated silencing glyoxalase 1 (GLO1), principal MG detoxifying...