We describe here the extraction and identification of several classes phenolic compounds from lichens Parmotrema dilatatum (Vain.) Hale, tinctorum (Nyl.) Pseudoparmelia sphaerospora Hale Usnea subcavata (Motyka) determined their anti-tubercular activity. The depsides (atranorin, diffractaic lecanoric acids), depsidones (protocetraric, salazinic, hypostictic norstictic xanthones (lichexanthone secalonic acid), usnic acid, as well seven orsellinic acid esters, five salazinic 8',9'-O-alkyl...

Lichens are an important source of phenolic compounds and have been intensively investigated for their biological pharmacological activities. Lecanoric acid (1), a lichen depside, was isolated from Parmotrema tinctorum specimen treated with alcohols to produce orsellinic (2) orsellinates (3) (9) (2,4-dihydroxy-6-n-methyl benzoates). Free radical scavenging activity methyl (3), ethyl (4), n-propyl (5), n-butyl (6), iso-propyl (7), sec-butyl (8), tert-butyl evaluated using...

The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones quantified by HPLC-DAD-UV. Promising antitubercular was observed with ethyl acetate extract (MIC 62.5 µg/mL) their fractions values ranging from 39 to above 250 µg/mL). better MIC result µg/mL associated two that contain bigger amounts 5,7-dihydroxy-6, 8-di-C-methylflavanone 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These...

Microparticles will probably play a promising role in the future of chemotherapy. These polymeric delivery systems are capable maximizing therapeutic activity while reducing side effects anti-cancer agents. Usnic acid (UA) is secondary metabolite produced by lichens, which exhibits an anti-tumour activity. In this study, PLGA-microspheres containing usnic from Cladonia substellata were prepared double emulsion method, with or without PEG as stabilizer. The morphology microspheres was...

The protocetraric acid (1) is a depsidone produced by countless species of lichens and has shown potential biological activity. In this work, we evaluated through the sulforhodamine B (SRB) assay cytotoxic activity seven alkyl ether derivatives (9´-O-alkyl acid) against following cell lines: HT-29 (colon carcinoma), 786-0 (kidney MCF7 (breast HEP2 (laryngeal PC-03 (prostate B16F10 (murine melanoma), UACC-62 (human NIH/3T3 (mouse embryonic fibroblast). Most compounds were to tested cells,...

Five flavanones and three chalcones were isolated from Campomanesia adamantium Berg. (Myrtaceae) leaves. The contents of these compounds determined by HPLC. phenolic also determined. monitoring the antioxidant activity was carried out inhibition peroxidation using linoleic acid system radical-scavenging (DPPH). plants collected 4 distinct cities Mato Grosso do Sul State, Brazil. different samples exhibited a range 4.67-232.35 mg/g 15.62-50.71 7.24-21.19 gallic acid. All extracts showed high...

The essential oils from Campomanesia adamantium (Cambess.) O. Berg leaves, collected in the reproductive (flowering and fruit-bearing) vegetative stages, were characterized by GC-MS (Gas Chromatography-Mass Spectrometry). A total of 95 compounds identified. In stage (flowering) major constituents monoterpenes (limonene, α-pinene β-pinene) while during sesquiterpenes (bicyclogermacrene globulol). oil shows high antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa...

The antimicrobial activity of the hexanic extracts and fractions fruits Campomanesia pubescens (D.C) O. Berg adamantium (Cambess.) were assayed against six microorganisms. C. also investigated in their composition by gas chromatography-mass spectrometry high-performance liquid chromatography with diode array detection. results this study showed presence 34 volatile compounds flavonoids extract 33 adamantium.

Serjania erecta Radlk.(Sapindaceae) is a medicinal plant traditionally used in Brazil. We assayed the ethanolic extract of leaves and roots against seven microorganisms. The REMA (Resazurin Microtiter Assay) assay was to measure biological activity vitro Mycobacterium tuberculosis our results showed moderate extract. On other hand S. aureus, P. aeruginosa, setubal, C. albicans, cerevisiae E. coli revealed that inhibited growth all extracts low values antioxidant activities. were analyzed by...

We surveyed the genus Hypotrachyna in “Parque Estadual da Cantareira” (Cantareira State Park) and its surroundings found 12 species. Its species are recognized as having foliose thalli with narrow laciniate to sublaciniate lobes, usually ≤ 1.0 cm wide, typical dichotomously branching rhizines eciliate margins. Some have a thick marginal line that can be confused cilia. Their medullary chemical constituents one of most complex among Parmeliaceae, many substances not yet identified. In this...

Campomanesia adamantium (Cambess.) O. Berg, Myrtaceae, é uma espécie nativa. As folhas são utilizadas na medicina popular. Os extratos hexânico e acetato de etila das mostraram pouca variação sua composição química em diferentes estações do ano associado com o desenvolvimento vegetal, enquanto extrato etanólico mostrou alteração significativa relação à química. Todos os etanólicos alta atividade antioxidante frente ao método DPPH moderada a para β-caroteno/ácido linoléico.

Several applications have been proposed for tyrosinase inhibitors in the pharmaceutical, food bioprocessing, and environmental industries. However, only a few compounds are known to serve as effective inhibitors. This study evaluated tyrosinase-related activity of resorcinol (1), orcinol (2) lecanoric acid (3), derivatives this (4-15). Subjected alcoholysis, depside isolated from lichen Parmotrema tinctorum, produces orsellinic (2,4-dihydroxy-6-methylbenzoic acid) (4) orsellinates...

Five flavanones and three chalcones were isolated from Campomanesia adamantium Berg. (Myrtaceae) leaves. The contents of these compounds determined by HPLC. phenolic also determined. monitoring the antioxidant activity was carried out inhibition peroxidation using linoleic acid system radical-scavenging (DPPH). plants collected 4 distinct cities Mato Grosso do Sul State, Brazil. different samples exhibited a range 4.67-232.35 mg/g 15.62-50.71 7.24-21.19 gallic acid. All extracts showed high...

In order to obtain new compounds with antibacterial activity, the derivatives 2,4-dihydroxy-6-methylbenzoic acid (orsellinic acid) and 2,4-dihydroxy-6-methylbenzoates (orsellinates) were obtained through alcoholyses of lecanoric acid. All these substances tested against Gram-positive Gram-negative bacteria by a microdilution method. Staphylococcus aureus, Xanthomonas campestris var. vesicatoria Ralstonia solanacearum most sensitive n-propyl 2,4-dihydroxy-6-methylbenzoate, n-pentyl...

CHEMICAL AND BIOLOGICAL STUDIES OF Microgramma vacciniifolia (LANGSD.& FISCH.)COpEL (pOLypODIACEAE).Chemical studies with aerial parts of (Langsd.& Fisch.)Copel.afforded β-sitosterol, hopan-22-ol, 6-metoxiapinenin-7-O-β-D-allopyranoside and a mixture containing ethyl esters carboxilic acids.The structures the coumpounds were elucidated by spectroscopy GC-MS analysis.The total phenolics contents crude extract fractions determined Folin-Ciocalteau method.The antioxidant activity was evaluated...

Bromelia balansae (Family Bromeliaceae) is a medicinal plant commonly used in the central region of Brazil as cough syrup and also eaten roasted. The methanolic extract ripe fruits was analyzed by chromatographic methods spectrometrically. Four glycoside flavonols were isolated: kaempferol-3-O-α-L-rhamnopyranoside (1), kaempferol-3-O-α-L-rhamnopyranosyl-(1-->6)-ß-D-glucopyranoside (2), quercetin-3-O-α-L-rhamnopyranosyl-(1-->6)-ß-d-glucopyranoside (3), kaempferol 3,7-di-O-α-L-rhamnopyranoside...

ALLELOPATHIC POTENTIALS OF Adiantum tetraphyllum HUMB.& BONPL.EX.WILLD (PTERIDACEAE).Chemical studies of green leaves A. afforded β-sitosterol, a mixture containing the ethyl esters long chain carboxylic acids, 30-normethyl-lupan-20-one, hopan-22-ol, phytol, phyten-3(20)-1,2-diol, quercetin and quercetin-3-O-β-D-glucoside.The structures compounds were elucidated by spectroscopic GC analysis.The allelopathic potentials crude ethanolic extract fractions evaluated against Lactuca sativa...

Environmental degradation caused by the excessive use of pesticides has motivated studies aimed at discovery new formulations for pest control. The bioassays carried out under laboratory conditions present study involved germination and seedling growth Lactuca sativa cv. Grand Rapids Allium cepa Baia Periforme treated with lecanoric acid or one seven esters obtained from alcoholysis acid. Each substance was tested concentrations 10-3, 10-5, 10-7 M, 10-9 M. results revealed that, except...