Liver and serum metabolites of obese lean mice fed on high fat or normal diets were analyzed using ultraperformance liquid chromatography-quadrupole-time-of-flight mass spectrometry, gas chromatography-mass partial least-squares-discriminant analysis (PLS-DA). Obese groups clearly discriminated from each other PLS-DA score plot major contributing to the discrimination assigned as lipid (fatty acids, phosphatidylcholines (PCs), lysophosphatidylcholines (lysoPCs)), metabolism intermediates...

Abstract Background Magnolia kobus DC (MO), as a plant medicine, has been reported to have various physiological activities, including neuroprotective, anti-inflammatory, and anti-diabetic effects. However, vascular protective effects of MO remain incompletely understood. In this study, we evaluated the effect against ferroptosis in carotid artery ligation (CAL)-induced neointimal hyperplasia mouse model aortic thoracic smooth muscle A7r5 cells. Methods This study was conducted estimate by...

There has been controversy as to whether the antiproliferative activity of dietary phenolic substances on cancer cells is due bioactivities phenolics or generation hydrogen peroxide (H2O2) in media an artifact. This study was investigate formation H2O2 by different induces acute toxicity and carcinogenicity normal rat liver epithelial cells. Gallic acid, one major antioxidants present fruits vegetables, dose-dependently generated considerably more DMEM without than did quercetin. acid...

Green tea (GT) consumption helps to prevent and control obesity by stimulating hepatic lipid metabolism. However, GT-induced changes in serum liver metabolomes associated with the anti-obesity effects are not clearly understood. The aim of this study was identify validate metabolomic profiles livers sera GT-fed obese mice elucidate relationship between GT prevention.Serum metabolites were analyzed fed normal diet, high-fat diet (HFD), HFD GT, crude catechins, using LC-quadrupole TOF MS....

Over the last several decades, there has been a considerable growth in type 2 diabetes (T2DM) Asians. A pathophysiological mechanism Asian T2DM is closely linked to low insulin secretion, β-cell mass, and inability compensate for resistance. We hypothesized that genetic variants associated with lower mass function their combination unhealthy lifestyle factors significantly raise risk among This hypothesis was explored participants aged over 40. Participants were categorized into (case; n =...

The antidiabetic effect of the Citrus junos Tanaka (also known as yuja or yuzu) was examined. Ethanol extract peel (YPEE) significantly stimulated 2-[ N -(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) uptake in C2C12 myotubes. However, ethanol pulp (YpEE) and water (YPWE) (YpWE) did not stimulate glucose uptake. In addition, peroxisome proliferator-activated receptor gamma (PPAR-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Scope Natural compounds that regulate peroxisome proliferator‐activated receptor alpha (PPARα) have been reported to beneficial effects in obesity‐mediated metabolic disorders. In this study, we demonstrated biochanin A (BA), an agonist of PPAR‐α, improved hepatic steatosis and insulin resistance by regulating lipid glucose metabolism. Methods results C57BL/6 mice were fed a normal chow diet, high‐fat diet (HFD), HFD supplemented with 0.05% BA for 12 weeks. Histological biochemical...

Generalized healthy eating patterns may not benefit everyone due to different genetics and enterotypes. We aimed compare the effects of a low-glycemic diet representing Korean traditional balanced (Low-GID) westernized as control (CD) on anthropometry, serum metabolites, fecal bacteria in randomized clinical trial according recruited 52 obese women aged 30–50 years, they consumed Low-GID CD meals for 1 month, with 1-month washout period, crossover trial. The was mainly composed whole grains...

Decursin (De), an active component of Angelica gigas , is known to exert anticancer and neuroprotective effects. However, its antiobesity antidiabetic potential has not yet been investigated. This study evaluated the effect decursin, particularly focusing on ability inhibit adipocyte differentiation in 3 T3‐L1 cells. treatment resulted inhibition expression fatty acid synthase. The further investigated these effects using mice fed a normal diet (ND), high‐fat (HFD) HFD plus decursin 200...

Nonalcoholic fatty liver disease (NAFLD) is the most common disease, and associated with development of metabolic syndrome. Postmenopausal women estrogen deficiency are at a higher risk progression to NAFLD. Estrogen has protective effect against disease. Currently, there no safe effective treatments for these diseases in postmenopausal women. Honokiol (Ho), bioactive natural product derived from Magnolia spp, anti-inflammatory, anti-angiogenic, anti-oxidative properties. In our study, we...

A traditional balanced Korean diet (K-diet) may improve energy, glucose, and lipid metabolism. To evaluate this, we conducted a randomized crossover clinical trial, involving participants aged 30-40 years, who were randomly assigned to two groups-a K-diet or westernized control daily, with an estimated energy requirement (EER) of 1900 kcal. After 4-week washout period, they switched the followed it for 4 weeks. The carbohydrate, protein, fat ratios based on intake close target values...

Fructus (SCF) is a traditional medicinal herb containing lignans that improves glucose metabolism by mitigating insulin resistance. We aimed to investigate the therapeutic potential and action mechanism of SCF for Alzheimer's disease (AD) using network pharmacology analysis, followed experimental validation in an AD rat model.

We evaluated the effects of two main kiwifruit cultivars (gold (GOK) and green (GRK)) their active phenolic compound, quercetin, on H 2 O -induced inhibition gap-junction intercellular communication (GJIC) in WB-F344 rat liver epithelial cells. found that both GOK GRK protect cells from GJIC. The extracellular signal-regulated protein kinase 1/2 (ERK1/2)–connexin 43 (Cx43) signalling pathway is crucial for regulation GJIC, blocked phosphorylation Cx43 ERK1/2 Quercetin alone attenuated...

trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used a variety of applications nanotechnology, including pharmaceutical cosmetic applications. Here, we aimed to evaluate the antioxidant effects tCIN self-included β-CD complexes (CIs) lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. macrophages were treated with increasing concentrations...

Inflammatory bowel disease (IBD) is characterized by inflammation, angiogenesis, and lymphangiogenesis. Artemisinin (Art), a chemical compound isolated from Artemisia annua L. (sweet wormwood), has several biochemical properties including antibacterial, anticancer, anti-inflammation, anti-angiogenesis effects. We investigated the effects of Art on inflammation-induced lymphangiogenesis in dextran sulfate sodium (DSS)-induced mouse acute colitis model. The mice were orally administered for 7...

Obese Asians are more susceptible to metabolic diseases than obese Caucasians of the same body mass index (BMI). We hypothesized that genetic variants associated with obesity risk interact lifestyles middle-aged and elderly adults, possibly allowing development personalized interventions based on genotype. aimed examine this hypothesis in a large city hospital-based cohort Korea. The participants cancers, thyroid diseases, chronic kidney disease, or brain-related were excluded. divided into...

Magnolia kobus DC. (MO) is a medicinal plant that reportedly possesses various bioactive properties, including anti-hyperplastic, anti-inflammatory, and anti-cancer effects. Chronic kidney disease (CKD) progressive disorder characterized by inflammation, fibrosis, oxidative stress, which leads to renal dysfunction. This study aimed evaluate the renoprotective effects of MO against adenine-induced CKD in C57BL/6 mice. significantly attenuated injury reducing blood urea nitrogen level...