A5069722067- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Nutritional Studies and Diet
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Nutrition, Health and Food Behavior
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Clostridium difficile and Clostridium perfringens research
- Sirtuins and Resveratrol in Medicine
- Pancreatic function and diabetes
- Biochemical effects in animals
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- Congenital heart defects research
- Gut microbiota and health
- Bee Products Chemical Analysis
Korea Food Research Institute
2016-2024
Soonchunhyang University
2023
University of Science and Technology
2023
Korea University of Science and Technology
2016-2022
Konkuk University Medical Center
2013
Rebecca Sieff Hospital
2013
Seoul National University Hospital
2010
Scope Natural compounds that regulate peroxisome proliferator‐activated receptor alpha (PPARα) have been reported to beneficial effects in obesity‐mediated metabolic disorders. In this study, we demonstrated biochanin A (BA), an agonist of PPAR‐α, improved hepatic steatosis and insulin resistance by regulating lipid glucose metabolism. Methods results C57BL/6 mice were fed a normal chow diet, high‐fat diet (HFD), HFD supplemented with 0.05% BA for 12 weeks. Histological biochemical...
Generalized healthy eating patterns may not benefit everyone due to different genetics and enterotypes. We aimed compare the effects of a low-glycemic diet representing Korean traditional balanced (Low-GID) westernized as control (CD) on anthropometry, serum metabolites, fecal bacteria in randomized clinical trial according recruited 52 obese women aged 30–50 years, they consumed Low-GID CD meals for 1 month, with 1-month washout period, crossover trial. The was mainly composed whole grains...
A traditional balanced Korean diet (K-diet) may improve energy, glucose, and lipid metabolism. To evaluate this, we conducted a randomized crossover clinical trial, involving participants aged 30-40 years, who were randomly assigned to two groups-a K-diet or westernized control daily, with an estimated energy requirement (EER) of 1900 kcal. After 4-week washout period, they switched the followed it for 4 weeks. The carbohydrate, protein, fat ratios based on intake close target values...
Luteolin, a naturally derived flavonoid, exerts beneficial effects such as antitumor, antioxidant, and anti-inflammatory effects. However, the molecular mechanism underlying effect of luteolin in hypercholesterolemia remains unclear. In this study, we demonstrated that upregulated expression liver X receptor (LXR) α, ATP-binding cassette transporter G1 (ABCG1), scavenger class B member 1 (SRB1), which play major role cholesterol efflux, HepG2 hepatocytes. Luteolin-stimulated ABCG1 SRB1 was...
This study investigated the effects of caffeic acid phenethyl ester (CAPE), a bioactive component honeybee hives, on prevention and treatment metabolic syndrome (MetS) by comparing efficacy CAPE intake at beginning obesity after obesity. The functional mechanism was also investigated.C57BL/6 mice were fed high-fat diet (HFD) containing 0.05% (HFD+C) for 12 weeks (HFD+C(Pre) group) or received HFD+C 6 consuming HFD (HFD+C(Post) group). Both CAPE-fed groups showed significant improvements in...
Shaofu Zhuyu decoction (SFZYD, also known as Sobokchugeo-tang), a classical prescription drug in traditional East Asian medicine, has been used to treat blood stasis syndrome (BSS). Hepatic steatosis is the result of excess caloric intake, and its pathogenesis involves internal retention phlegm dampness, stasis, liver Qi stagnation. To evaluate effects treatment with SFZYD on obesity-induced inflammation hepatic steatosis, we fed male C57BL/6N mice high fat diet (HFD) for 8 weeks then...
Human omentum-derived mesenchymal stem cells (hO-MSCs) possess great potential to differentiate into multiple lineages and have self-renewal capacity, allowing them be utilized as patient-specific cell-based therapeutics. Although the use of various cell-derived β-cells has been proposed a novel approach for treating diabetes mellitus, developing an efficient method establish highly functional remains challenging. We aimed develop cell culture platform that utilizes fibroblast growth factor...
Hepatic steatosis is the most common chronic liver disease in Western countries. Both genetic and environmental factors are known as causes of although their underlying mechanisms have not been fully understood. This study investigated association DNA methylation with oleic acid-induced hepatic steatosis. It also examined effects food components on Genome-wide acid (OA)-induced lipid accumulation vitro cell model was using reduced representation bisulfite sequencing. Changes were analyzed...
Abstract Background and Aims FABP4, a fatty acid-binding protein, is predominantly expressed in adipose tissue (AT) has been shown to be elevated patients with chronic kidney disease (CKD). Although levels of FABP4 have linked cardiovascular end-stage renal (ESRD) patients, the cause this increase unclear. The aim study was evaluate expression AT under uremic conditions its impact on function macrophages vascular smooth muscle cells (VSMC). Method We measured blood urine CKD patients....
<title>Abstract</title> <bold>Introduction</bold> Ginseng berry (GB) has previously been demonstrated to improve systemic insulin resistance and regulate hepatic glucose metabolism steatosis in mice with diet-induced obesity (DIO).<bold>Objectives</bold> In this study, the role of GB was assessed using metabolomics analysis on total liver metabolites DIO mice.<bold>Methods</bold> Metabolomic profiling performed capillary electrophoresis time-of-flight mass spectrometry (CE-TOF/MS) tissue...
The efficacy and safety of traditional medicine could be proved through human trial for a long time, now it has been required the scientific evidence its identification specific functional target. Tongqiaozuoxue Decoction (THD) is water extract 8 species medicinal herb including Cnidium officinale Makino Prunus persica Batsch, used treatment blood stasis hypercoagulation in Korean medicine. This study investigated THD target using animal model. Early vascular model was established feeding...
Metabolomics is a powerful technology used in biomarker discovery and assessing the physiological effects neutraceuticals pharmaceuticals. Modulation of metabolic responses associated with obesity may help prevent or improve obesity‐induced dysfunctions. Recently, we reported that biochanin A (BA), dietary bioactive isoflavone most commonly found red clover, peanuts, alfalfa sprouts soy ameliorates impaired lipid homeostasis hepatic steatosis. In this study, capillary electrophoresis‐MS...