A5080531801- Hearing, Cochlea, Tinnitus, Genetics
- Sleep and Wakefulness Research
- Vestibular and auditory disorders
- Sleep and related disorders
- Neuroscience and Neural Engineering
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Hearing Loss and Rehabilitation
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Rate Variability and Autonomic Control
- Peroxisome Proliferator-Activated Receptors
- Neurological disorders and treatments
- 3D Printing in Biomedical Research
- Obstructive Sleep Apnea Research
- Fatty Acid Research and Health
- Drug Transport and Resistance Mechanisms
- Amino Acid Enzymes and Metabolism
- Pharmacogenetics and Drug Metabolism
- Photoreceptor and optogenetics research
- Immune Response and Inflammation
- Cannabis and Cannabinoid Research
The Ohio State University
2019-2023
Beth Israel Deaconess Medical Center
2014-2020
Harvard University
2020
Hadassah Medical Center
2017
University of Massachusetts Chan Medical School
2011
Age-related hearing loss (ARHL) is a major impairment characterized by pathological changes in both the peripheral and central auditory systems. Low-grade inflammation was observed cochlea of deceased human subjects with ARHL animal models early onset ARHL, which suggests that contributes to development ARHL. However, it remains elusive how chronic progresses during normal aging cochlea, especially accompanying neuroinflammation system. To address this, we investigated cochlear nucleus (CN)...
Key points Sound information is transmitted by different subtypes of spiral ganglion neurons (SGN) from the ear to brain. Selective damage SGN peripheral synapses (cochlear synaptopathy) widely recognized as one primary mechanisms hearing loss, whereas at central remain unclear. We report that converge ratios onto individual target cochlear nucleus with distinct physiological properties, and show biased morphological changes during age‐related loss (ARHL). The results reveal a new dimension...
Hearing loss is characterized by dysfunction and pathological changes of the cochlea, including sensory hair cells connected synapses. Growing evidence has revealed that immune system plays critical roles in shaping cochlear responses to tissue injury clearance damaged under conditions such as noise-induced hearing (NIHL). However, underlying mechanisms regulate this process remain unclear. As a crucial part innate system, complement widely known respond damage help remove cellular debris....
Post-learning sleep is beneficial for human memory. However, it may be that not all memories benefit equally from sleep. Here, we manipulated a spatial learning task using monetary reward and performance feedback, asking whether enhancing the salience of would augment overnight memory consolidation alter its incorporation into dreaming. Contrary to our hypothesis, found addition impaired Our findings seemingly contradict prior reports value learned information augments sleep-dependent...
Patients with schizophrenia (SZ) have a specific deficit in sleep spindles that correlates impaired memory consolidation and symptom severity. In small placebo-controlled pilot study we found eszopiclone, non-benzodiazepine hypnotic drug acts on GABAA receptors the thalamus where are generated, increased SZ but its effect was not significant. Here employed more powerful cross-over design recruited larger sample to investigate effects of eszopiclone spindle activity sleep-dependent...
Precisely engineered neuronal circuits are promising for both fundamental research and clinical applications. However, randomly plating thousands of cells during neural network fabrication remains a major technical obstacle, which often results in loss tracking neurons' identities. In this work, we demonstrated an accurate unique wiring technique, mimicking natural affinity to microfibers. SU-8 microridges, imitating lie-down microfibers, were photolithographically patterned then selectively...
Objective.Therapeutic intervention for Parkinson's disease (PD) via deep brain stimulation (DBS) represents the current paradigm managing advanced stages of in patients when treatment with pharmaceuticals becomes inadequate. Although DBS is prevailing therapy these cases, overall effectiveness and reliability can be diminished over time due to hardware complications biocompatibility issues electronic implants. To achieve a lifetime solution, we envision that next generation neural implants...
Bioelectronic medicine uses electrical stimulation of the nervous system to improve health outcomes throughout body primarily by regulating immune responses. This concept, however, has yet be applied systematically auditory system. There is growing interest in how cochlear damage and associated neuroinflammation may contribute hearing loss. In conjunction with recent findings, we propose here a new perspective, which could alongside advancing technologies, use nerve (AN) modulate responses...
SUMMARY Sound information is transmitted from the cochlea to brain by different subtypes of spiral ganglion neurons (SGN), which show varying degrees vulnerbility under pathological conditions. It remains unclear how these SGNs reassemble among target in cochlear nucleus (CN) at auditory nerve (AN) central synapses, and synapses change during hearing loss. Combining immunohistochemistry with electrophysiology, we investigated giant endbulb Held their postsynaptic bushy mice normal...
Background: Cognitive deficits, a highly disabling feature of schizophrenia (SZ), are the strongest predictor functional outcome. Recent evidence points to thalamocortical circuitry as culprit in SZ risk and cognitive deficits. Patients with have reduced sleep spindles (bursts 12–15 Hz electroencephalogram activity during non-rapid eye movement sleep), which initiated by thalamic reticular nucleus propagated synchronized cortex via feedback loops. Sleep mediate memory consolidation...