A5070234236- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Cancer Research and Treatments
- Developmental Biology and Gene Regulation
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Nerve injury and regeneration
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Ubiquitin and proteasome pathways
- Cellular Mechanics and Interactions
- Cancer, Hypoxia, and Metabolism
- Heat shock proteins research
- Protein Kinase Regulation and GTPase Signaling
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
- GDF15 and Related Biomarkers
- IL-33, ST2, and ILC Pathways
- Cancer Genomics and Diagnostics
- Neurofibromatosis and Schwannoma Cases
- Cancer Mechanisms and Therapy
King Abdullah International Medical Research Center
2018-2024
King Saud bin Abdulaziz University for Health Sciences
2021-2023
Harvard University
2022-2023
Dana-Farber Cancer Institute
2022-2023
National Guard Health Affairs
2021-2022
King Abdulaziz Medical City
2021-2022
Impact Technology Development (United States)
2022
University of Calgary
2015-2020
Cancer Institute (WIA)
2018
Abstract Despite a deeper molecular understanding, human glioblastoma remains one of the most treatment refractory and fatal cancers. It is known that presence macrophages microglia impact tumorigenesis prevent durable response. Herein we identify dual function cytokine IL-33 as an orchestrator microenvironment contributes to tumorigenesis. We find expression in large subset glioma specimens murine models correlates with increased tumor-associated macrophages/monocytes/microglia. In...
Abstract The fidelity of synaptic transmission depends on the integrity protein machinery at synapse. Unfolded proteins undergo refolding or degradation in order to maintain proteostasis and preserve function, buildup unfolded/toxic leads neuronal dysfunction. Many molecular chaperones contribute proteostasis, but one particular, cysteine string (CSPα), is critical for In this study we report that exported vesicles from neurons contain CSPα. Extracellular (EV’s) have been implicated a wide...
The invasive nature of glioblastoma renders them incurable by current therapeutic interventions. Using a novel human glioma model, we previously identified the neurotrophin receptor p75(NTR) (aka CD271) as mediator invasion. Herein, provide evidence that preventing phosphorylation on S303 pharmacological inhibition PKA, or mutational strategy (S303G), cripples p75(NTR)-mediated invasion resulting in serine within C-terminal PDZ-binding motif (SPV) p75(NTR). Consistent with this, deletion...
Abstract Capicua (Cic) is a transcriptional repressor mutated in the brain cancer oligodendroglioma. Despite its link, little known of Cic’s function brain. We show that nuclear Cic expression strongest astrocytes and neurons but weaker stem cells oligodendroglial lineage cells. Using new conditional knockout mouse, we demonstrate forebrain-specific deletion increases proliferation self-renewal neural Furthermore, loss biases toward glial selection, expanding pool oligodendrocyte precursor...
Abstract The selectivity of (4Z)-2-(4-chloro-3-nitrophenyl)-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one (DI) for zipper-interacting protein kinase (ZIPK) was previously described by in silico computational modeling, screening a large panel kinases and determining the inhibition efficacy. Our assessment DI revealed another target, Rho-associated coiled-coil-containing 2 (ROCKII). In vitro studies showed to be competitive inhibitor ROCKII (Ki, 132 nM with respect ATP). This finding supported...
COVID-19 is newly emerging infectious disease that spread globally at unpredictable and unique pattern to the extent World Health Organization announced as a pandemic in first couple months of 2020. This study aims describe clinical demographic features patients influence various risk factors on severity disease. research retrospective based Saudi Arabia's ministry health's Covid-19 data. The analysis relies data all recorded Riyadh between 1st, March 2020 30th, July Statistical analyses...
Despite extensive molecular characterization, human glioblastoma remains a fatal disease with survival rates measured in months. Little improvement is seen standard surgery, radiotherapy and chemotherapy. Clinical progress hampered by the inability to detect target reservoirs based on diffuse invasive pattern presence of phenotypic heterogeneity. The goal this study was stem-like cells that evade first-line treatments using agents capable delivering imaging enhancers or biotherapeutic cargo....
The protein kinase TAOK3, belongs to the MAP family, is one of three closely related members, namely TAOK1, TAOK2, and TAOK3. We performed a pan-cancer investigation TAOK3 across different cancer types, including uterine carcinosarcoma, adenocarcinoma stomach pancreas, endometrial carcinoma uterus, better understand TAOK3's role in cancer. In at least 16 types cancer, our findings indicate that expression levels differ considerably between normal tumor tissues. addition, study first identify...
Abstract Colorectal cancer (CRC) is the one of most common cancers and a major leading cause cancer-related death worldwide. CDC20 key cell cycle regulator required during mitosis. Pathologically, has been found to be overexpressed in cells various malignancies including breast, lung, brain hepatic high level expression associated with poor prognosis disease progression these cancers. Although it reported that CRC metastasis, still largely unknown how regulates progression. Thus, goal this...
ABSTRACT Capicua (Cic) is a transcriptional repressor mutated in the brain cancer oligodendroglioma. Despite its link, little known of Cic’s function brain. Here, we investigated relationship between Cic expression and cell type specification strongly expressed astrocytic neuronal lineage cells but more weakly stem oligodendroglial cells. Using new conditional knockout mouse, show that forebrain-specific deletion increases proliferation self-renewal neural Furthermore, loss biases toward...
Abstract Human glioblastoam is a heterogeneous tumor composed of cells and small population known as brain initiating (BTICs) or glioblastoma stem-like cells. BTICs appear to drive progression, underlie therapeutic resistance have been highlighted targets for patients with malignant glioma. The ability glioma invade into the surrounding parenchyma major clinical issue rendering incurable by conventional therapies. In previous study, we found that p75 neurotrophin receptor (p75NTR)...
Capicua (Cic) is an evolutionarily conserved HMG box-containing transcriptional repressor. Mutations in the CIC gene (encoded on human chr 19q) have been found a diverse range of cancers, but are most striking their association with oligodendrogliomas (ODGs), where tumor cells bear resemblance to immature oligodendrocytes or OPCs. mutations present two thirds ODGs and occur setting concurrent 1p/19q loss IDH1/2 mutation. Although its link established, little known role that Cic plays during...
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor associated with high mortality rate, an average survival time of less than two years. GBM treatment faces significant challenges due to its infiltrative nature, genetic diversity, protection by the blood-brain barrier (BBB), drug resistance, and post-treatment side effects. Transcription factors (TFs) play crucial role in regulating gene expression during cancer initiation progression. This study aimed investigate impact...
Epigenetic mechanisms, such as histone deacetylases (HDACs), play an important role in the commencement and development of hepatocellular carcinoma (HCC). Previously, we have identified proteins with binds HDAC1 HDAC3 liver cancer cells also shown that depletion either or suppressed expression HDAC1/3 interacting proteins, including prefoldin protein 2/6 (PFDN2/6), CR4-NOT transcription complex subunit 1 (CNOT1), high mobility group 20B (HMG20b). In this study, online databases were utilized...