A5053177700- Alzheimer's disease research and treatments
- Protein Interaction Studies and Fluorescence Analysis
- Protein Hydrolysis and Bioactive Peptides
- Chronic Kidney Disease and Diabetes
- Protease and Inhibitor Mechanisms
- Retinoids in leukemia and cellular processes
- Advanced Glycation End Products research
- Liver Disease Diagnosis and Treatment
- Microbial Metabolites in Food Biotechnology
- Nuclear Receptors and Signaling
- Medicinal plant effects and applications
- Protein purification and stability
- biodegradable polymer synthesis and properties
- Folate and B Vitamins Research
- Neonatal Health and Biochemistry
- Dialysis and Renal Disease Management
- Alcohol Consumption and Health Effects
- COVID-19 Clinical Research Studies
- Erythrocyte Function and Pathophysiology
- Antioxidant Activity and Oxidative Stress
- Phytase and its Applications
- Biomedical Research and Pathophysiology
- Phytochemicals and Antioxidant Activities
- Nanoparticle-Based Drug Delivery
- ATP Synthase and ATPases Research
Wroclaw Medical University
2013-2022
Instytut Farmaceutyczny
2021
The aim of this study was to analyze the antibacterial activity hen egg white cystatin against selected Escherichia coli strains. We used a monomeric solution in bovine serum albumin (BSA) with added phosphate buffered saline (PBS), and three test strains: ATCC 23811, 8739 25922. effect tested strains determined on basis minimal inhibitory concentration (MIC) survival curves microorganisms cystatin-containing environment during incubation at various temperatures. Our confirmed analyzed...
The disease caused by coronavirus SARS-CoV-2 (COVID-19) can affect almost all organs of the human body, including kidneys. We conducted a one-center study to comprehensively analyze effects kidney involvement on course and outcomes in patients hospitalized with COVID-19, depending estimated glomerular filtration rate (eGFR) at admission. Out 1958 patients, 1342 (68.54%) had eGFR ≥ 60 mL/min/1.73 m2 (group A) 616 (31.46%) < B). Group B was additionally divided into subgroups B1, B2, B3 based...
Ovocystatin is a chicken egg white protein, generally known for its inhibitory activity against cysteine proteases. However, biological of ovocystatin does not seem to be well recognized in respect other possible cellular effects. Our attention has been focused on cytotoxic effects relation influence actin cytoskeleton organization and apoptosis induction. In vitro studies with human melanoma A375, cervix HeLa cancer cells normal fibroblasts - NHDF were done. Cytotoxic was seen induction...
Background: Ovocystatin is marked by structural and biological similarities to human cystatin C, which plays an important role in the course of neurodegenerative diseases. Recently, it has been shown that ovocystatin might prevent aging-related cognitive impairment rats reduce memory decline APP/PS1 mice model. Thus, this study aimed assess effect on histopathological changes mice. Materials methods: was administered intraperitoneally for four weeks (40 μg/mouse) 35-weeks-old transgenic (AD,...
Proteins are natural and safe substitutes of the synthetic polymers for development drug delivery systems (DDS). Few proteins have been approved purposes by United States Food Drug Administration (FDA). Among them, albumin is most explored carrier synthesis therapeutic nanoparticles. Its usefulness was determined common accessibility, biocompatibility feasibility accumulation in tissues with increased metabolism. Albumin its properties particularly attractive anti-arthritis anti-cancer...
Introduction: Increased occurrence of cognitive deficits in mild impairment is related with the phenomenon aging within population. Cystatin C has been associated cysteine protease inhibiting properties as well an induction autophagy and proliferation that can potentially be used adjuvant treatment decline. The aim study was to evaluate effect ovocystatin, which structurally biologically similar cystatin C, on functions experimental young rat models. Material/Methods: (four-month-old)...
The aim of the study is to evaluate utility cystatin C (Cys C) determination in monitoring HIV seropositive patients, based on recent literature concerning clinical investigation. Determination serum CysC concentration can be helpful kidney function and eGFR (estimated GFR) calculation, however infection inflammation markers influence should included. A risk assessment appearance cardiovascular incidents risks all-cause mortality other application for this parameter. urinary serve as...
Treatments for NAFLDNon-alcoholic fatty liver disease (NAFLD) is categorized into simple steatosis, termed nonalcoholic (NAFL) and steatohepatitis (NASH).NASH characterized by hepatocyte damage, inflammation, fibrosis, which through cirrhosis leads to organ failure, including hepatocellular carcinoma.The development of effective non-alcoholic therapies depends on basic biomedical research metabolism or the body's response factors metabolic syndrome.This article presents important information...