A5013793142- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Platelet Disorders and Treatments
- Colorectal and Anal Carcinomas
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Cancer Diagnosis and Treatment
- Bone and Joint Diseases
- Dermatological and COVID-19 studies
- CNS Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Hematopoietic Stem Cell Transplantation
- Cancer Treatment and Pharmacology
- Retinoids in leukemia and cellular processes
- Glioma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Venous Thromboembolism Diagnosis and Management
- Viral-associated cancers and disorders
- Protein Degradation and Inhibitors
- Mechanisms of cancer metastasis
Bursa Uludağ Üni̇versi̇tesi̇
2014-2025
Sağlık Bilimleri Üniversitesi
2022
Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease. Supportive treatments, such as erythropoiesis-stimulating agents (ESAs), are commonly used in patients with low-risk MDS. This study aimed to retrospectively assess the impact of bone marrow Mothers against decapentaplegic homolog 7 (SMAD-7) and Transforming Growth Factor Beta 1 (TGF-β1) protein expression on prognosis response ESA treatment We analyzed diagnosed MDS at adult hematology department Bursa Uludağ...
Abstract The impact of inflammatory markers such as systemic immune-inflammation (SII) index and inflammation response (SIRI) on myelofibrosis (MF) prognosis was evaluated for the first time in this study. Data from 60 patients diagnosed with MF between March 2011 September 2022 were retrospectively analyzed. In addition to disease-related markers, SII SIRI evaluated. our study, overall median survival (OS) 64 months. OS significantly shorter older than 65 years, high ferritin lymphocyte...
Aims: It was aimed at measuring the comorbidities of chronic myeloid leukemia (CML) patients time diagnosis with different comorbidity indices and evaluating their effects on disease prognosis. Methods: The were retrospectively screened calculated in three indices: ACE-27 Comorbidity Index, Age-adjusted Charlson Elixhauser Index. C-statistic used to evaluate ability discriminate mortality. relationship between scores overall survival (OS) evaluated Kaplan-Meier curve. Mortality risk analyzed...
Background: Several thrombotic risk assessment models have been proposed for identifying patients with a high of thrombosis (the IMPEDE venous thromboembolism (VTE), SAVED, and PRISM scores) in multiple myeloma (MM). Recently, adding biomarker (D-dimer) the VTE score has shown that it can boost detection power IMPEDED VTE. However, data from studies comparing these MM are scarce. Even real-world arguing utility low- or middle-income countries like Türkiye lacking. Methods: We aimed to show...
Infections are the most common cause of anal and perianal pathologies in patients with hematological malignancies. Perianal infection diagnosis this group is difficult; thus, a careful anorectal examination necessary imaging modalities. In addition, literature reveals knowledge gap approach to neutropenia during or chemotherapy. This study aimed examine our institutional data on complications investigate relationship between white blood cell-neutrophil count, lesion, type treatment...
Triple-negative breast cancers (TNBCs) - which lack the expression of estrogen receptor (ER), progesterone (PR) and human epidermal growth factor 2 (HER-2) have no established markers that can be used for prognostic stratification. As adiponectin has been previously implicated in a more aggressive phenotype primary cancer, we explored relation between immunohistochemical prognosis TNBCs.Immunohistochemical staining was performed 38 TNBC patients. Disease-free survival (DFS) overall (OS)...
Previous reports have shown that human epidermal receptor (HER)-3 overexpression may be associated with poor prognosis in patients breast cancer, but results been conflicting. In this study, we sought to investigate the prognostic significance of HER-3 immunohistochemical expression metastatic cancer.We retrospectively analyzed profiles 45 paraffin-embedded specimens from who had treated between 1996 and 2006 Department Oncology Uludag University School Medicine, Bursa, Turkey. Membranous or...
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening occlusive disease of the microcirculation characterized by systemic platelet plugs, organ ischemia, deep thrombocytopenia, and fragmentation erythrocytes. One widely used scoring system to determine clinical probability TTP PLASMIC system. This study aimed evaluate contribution score modifications sensitivity specificity in patients with microangiopathic hemolytic anemia (MAHA) undergoing plasma exchange prediagnosis at our...
FLAG-Ida protokolü (Fludarabin- Sitarabin- Granülosit Koloni Stimülan Faktör- İdarubisin) relaps/refrakter akut lösemi olgularında sıklıkla uygulanan bir kemoterapi rejimidir. Özellikle ilaç erişiminde olan aksaklıklar nedeniyle, antrasiklin ajan olarak idarubisin yerine daunorubisin kullanılabilmektedir. Çalışmamızda, Bursa Uludağ Üniversitesi Hematoloji kliniğinde tanısı ile ya da FLAG-Dauno alan hastaların etkinlik ve yan etki verilerini değerlendirmeyi amaçladık. Çalışmaya toplam 94...
<title>Abstract</title> While the pathogenesis of Myelodysplastic Syndrome (MDS) is diverse, growing evidence suggests that inflammation significantly influences disease development and progression. This study sought to assess impact nutritional status on mortality, with a particular focus patients low-risk MDS. A retrospective analysis was conducted 175 newly diagnosed MDS patients. low Prognostic Nutritional Index (PNI) associated poorer prognosis (p<0.001). The optimal PNI cut-off...
Bu çalışma, relaps/refrakter malign lenfomalarda kullanılan otolog kök hücre nakli (OKİT) için iki farklı hazırlık rejimi olan BuCy-E ve BEAM'in etkinliği toksisite profillerini karşılaştırmaktadır. BEAM, lenfoma tedavisinde yaygın olarak rejimidir bu çalışmada her rejimin kısa dönem sonuçları retrospektif incelenmiştir. On ikisi Hodgkin Lenfoma (HL) 18'i Non-Hodgkin (NHL) tanısı alan toplam 30 hasta çalışmaya alınmıştır. Hastaların demografik özellikleri, tedavi yanıtları, yan etkiler...
Amaç: Bu çalışmada, opere edilmiş küçük hücreli dışı akciğer kanserli (KHDAK
Our study investigated leukapheresis's effect on delayed induction therapy outcomes in patients with acute leukemia presenting symptomatic hyperleukocytosis.This retrospective cohort included 30 adult diagnosed who underwent leukapheresis for leukostasis. The were divided into the first 24 h and >24 groups, according to time from diagnosis (TDT).There was no significant difference between TDT groups regarding complete remission (CR), 4-week mortality, overall survival (OS) at a median...
İlk oral proteazom inhibitörü (PI) olan iksazomib, lenalidomid ve deksametazon (IRd) ile kombinasyon halinde relaps refrakter multipl miyelomun (RRMM) tedavisi için onaylanmıştır. Bununla birlikte, klinik çalışma sonuçları her zaman gerçek dünyadaki sonuçlarla örtüşmez. Bu çalışmanın amacı, yaşamda RRMM'li hastaların iksazomib bazlı tedavisinin sonuçlarını değerlendirmektir. Çalışmaya Bursa Uludağ Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı’ndan toplam 45 RRMM tanılı hasta retrospektif...
Objectives: We aimed to evaluate the potential prognostic factors of patients with primary central nervous system lymphoma (PCNSL). Methods: Thirty-two PCNSL were retrospectively analyzed. Results: All received high doses methotrexate-based chemotherapy as first-line treatment. Overall survival was 30.0 ± 7.2 months. Those partial response and without had a higher risk mortality. The increased leukocyte neutrophil levels associated Besides, SIIL product systemic immune inflammation (SII)...
Background Hairy cell leukemia (HCL) is an uncommon neoplasm representing approximately 2% leukemias and
Background: Dapsone is a second-line therapy for immune thrombocytopenia (ITP). It cost-effective, with response rate comparable to other drugs used as therapy, such azathioprine, danazol, cyclophosphamide, cyclosporine, vincristine, rituximab, and eltrombopag.
 Material Methods: This retrospective study analyzed ten adult patients who presented our hematology division outpatient clinic between March 2013 July 2021, was diagnosed chronic/refractory ITP, did not respond first-line...