A5006120677- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Platelet Disorders and Treatments
- Dermatological and COVID-19 studies
- Kruppel-like factors research
- Lymphoma Diagnosis and Treatment
- Bone and Joint Diseases
- Anorectal Disease Treatments and Outcomes
- Hematopoietic Stem Cell Transplantation
- Glioma Diagnosis and Treatment
- Families in Therapy and Culture
- Genetic and rare skin diseases.
- Urinary Bladder and Prostate Research
- Helicobacter pylori-related gastroenterology studies
- Dialysis and Renal Disease Management
- Parvovirus B19 Infection Studies
- Colorectal and Anal Carcinomas
- CNS Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Protein Degradation and Inhibitors
Bursa Uludağ Üni̇versi̇tesi̇
2022-2025
Sağlık Bilimleri Üniversitesi
2022
Ali Osman Sonmez Oncology Hospital
2012-2021
Aims: It was aimed at measuring the comorbidities of chronic myeloid leukemia (CML) patients time diagnosis with different comorbidity indices and evaluating their effects on disease prognosis. Methods: The were retrospectively screened calculated in three indices: ACE-27 Comorbidity Index, Age-adjusted Charlson Elixhauser Index. C-statistic used to evaluate ability discriminate mortality. relationship between scores overall survival (OS) evaluated Kaplan-Meier curve. Mortality risk analyzed...
Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease. Supportive treatments, such as erythropoiesis-stimulating agents (ESAs), are commonly used in patients with low-risk MDS. This study aimed to retrospectively assess the impact of bone marrow Mothers against decapentaplegic homolog 7 (SMAD-7) and Transforming Growth Factor Beta 1 (TGF-β1) protein expression on prognosis response ESA treatment We analyzed diagnosed MDS at adult hematology department Bursa Uludağ...
Abstract The impact of inflammatory markers such as systemic immune-inflammation (SII) index and inflammation response (SIRI) on myelofibrosis (MF) prognosis was evaluated for the first time in this study. Data from 60 patients diagnosed with MF between March 2011 September 2022 were retrospectively analyzed. In addition to disease-related markers, SII SIRI evaluated. our study, overall median survival (OS) 64 months. OS significantly shorter older than 65 years, high ferritin lymphocyte...
Infections are the most common cause of anal and perianal pathologies in patients with hematological malignancies. Perianal infection diagnosis this group is difficult; thus, a careful anorectal examination necessary imaging modalities. In addition, literature reveals knowledge gap approach to neutropenia during or chemotherapy. This study aimed examine our institutional data on complications investigate relationship between white blood cell-neutrophil count, lesion, type treatment...
Bu çalışma, relaps/refrakter malign lenfomalarda kullanılan otolog kök hücre nakli (OKİT) için iki farklı hazırlık rejimi olan BuCy-E ve BEAM'in etkinliği toksisite profillerini karşılaştırmaktadır. BEAM, lenfoma tedavisinde yaygın olarak rejimidir bu çalışmada her rejimin kısa dönem sonuçları retrospektif incelenmiştir. On ikisi Hodgkin Lenfoma (HL) 18'i Non-Hodgkin (NHL) tanısı alan toplam 30 hasta çalışmaya alınmıştır. Hastaların demografik özellikleri, tedavi yanıtları, yan etkiler...
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening occlusive disease of the microcirculation characterized by systemic platelet plugs, organ ischemia, deep thrombocytopenia, and fragmentation erythrocytes. One widely used scoring system to determine clinical probability TTP PLASMIC system. This study aimed evaluate contribution score modifications sensitivity specificity in patients with microangiopathic hemolytic anemia (MAHA) undergoing plasma exchange prediagnosis at our...
FLAG-Ida protokolü (Fludarabin- Sitarabin- Granülosit Koloni Stimülan Faktör- İdarubisin) relaps/refrakter akut lösemi olgularında sıklıkla uygulanan bir kemoterapi rejimidir. Özellikle ilaç erişiminde olan aksaklıklar nedeniyle, antrasiklin ajan olarak idarubisin yerine daunorubisin kullanılabilmektedir. Çalışmamızda, Bursa Uludağ Üniversitesi Hematoloji kliniğinde tanısı ile ya da FLAG-Dauno alan hastaların etkinlik ve yan etki verilerini değerlendirmeyi amaçladık. Çalışmaya toplam 94...
<title>Abstract</title> While the pathogenesis of Myelodysplastic Syndrome (MDS) is diverse, growing evidence suggests that inflammation significantly influences disease development and progression. This study sought to assess impact nutritional status on mortality, with a particular focus patients low-risk MDS. A retrospective analysis was conducted 175 newly diagnosed MDS patients. low Prognostic Nutritional Index (PNI) associated poorer prognosis (p<0.001). The optimal PNI cut-off...
Parasitic infestations are mostly encountered in underdeveloped or developing countries.Taenia saginata is the most frequently found genus Turkey and cases occur particularly Southeastern Anatolian Region.A 57-year-old woman admitted to hospital with complaints of weakness, weight lose abdominal pain.Gastroscopy was performed a tumoral mass observed.Pathologic evaluation endoscopic biopsies reported as signet ring cell gastric carcinoma.Tapeworm incidentally observed when incision made for...
Our study investigated leukapheresis's effect on delayed induction therapy outcomes in patients with acute leukemia presenting symptomatic hyperleukocytosis.This retrospective cohort included 30 adult diagnosed who underwent leukapheresis for leukostasis. The were divided into the first 24 h and >24 groups, according to time from diagnosis (TDT).There was no significant difference between TDT groups regarding complete remission (CR), 4-week mortality, overall survival (OS) at a median...
İlk oral proteazom inhibitörü (PI) olan iksazomib, lenalidomid ve deksametazon (IRd) ile kombinasyon halinde relaps refrakter multipl miyelomun (RRMM) tedavisi için onaylanmıştır. Bununla birlikte, klinik çalışma sonuçları her zaman gerçek dünyadaki sonuçlarla örtüşmez. Bu çalışmanın amacı, yaşamda RRMM'li hastaların iksazomib bazlı tedavisinin sonuçlarını değerlendirmektir. Çalışmaya Bursa Uludağ Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı’ndan toplam 45 RRMM tanılı hasta retrospektif...
Background Hairy cell leukemia (HCL) is an uncommon neoplasm representing approximately 2% leukemias and
Background: Dapsone is a second-line therapy for immune thrombocytopenia (ITP). It cost-effective, with response rate comparable to other drugs used as therapy, such azathioprine, danazol, cyclophosphamide, cyclosporine, vincristine, rituximab, and eltrombopag.
 Material Methods: This retrospective study analyzed ten adult patients who presented our hematology division outpatient clinic between March 2013 July 2021, was diagnosed chronic/refractory ITP, did not respond first-line...
Objectives: We aimed to evaluate the potential prognostic factors of patients with primary central nervous system lymphoma (PCNSL). Methods: Thirty-two PCNSL were retrospectively analyzed. Results: All received high doses methotrexate-based chemotherapy as first-line treatment. Overall survival was 30.0 ± 7.2 months. Those partial response and without had a higher risk mortality. The increased leukocyte neutrophil levels associated Besides, SIIL product systemic immune inflammation (SII)...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Introduction: Essential Thrombocytemia (ET) is a clonal stem cell disease that manifests itself with proliferation in the megakaryocytic lineage bone marrow, clinical presentations ranging from asymptomatic to bleeding and thrombosis spectrum.
 In medical treatment, aspirin and/or monitoring are recommended for low-risk patients, while cytoreductive therapy high-risk patients. Cytoreductive often used patients very high platelet count (>1,000,000). The first choice treatment...
This study aimed to evaluate the effects of appropriate use empiric glycopeptide therapy in hematologic malignancy patients with febrile neutropenia (FN).Patients FN who were hospitalized our clinic and started retrospectively analyzed. Empiric treatment initial indications determined according 7 specific criteria IDSA guidelines. In addition, duration indications, causative pathogens culture positivity, frequency VRE infection, mortality rate was identified.87 included. Of these, 102...
Kronik Myeloid Lösemide (KML), etyolojisinde sorumlu tirozin kinaz aktivitesi gösteren bcr-abl füzyon geninin keşfinden sonra, bu aktiviteyi inhibe eden ilaçların keşfiyle, daha uzun sağkalım sürelerine ulaşılabilmiştir. Bu ilaçlarla tedaviye zamanla direnç gelişmesi, ikinci ve üçüncü kuşak ajanların geliştirilmesinin önünü açmıştır. çalışmamızda, merkezimizde inhibitörü (TKİ) – bosutinib - tedavisi alan hastaların, klinik, laboratuvar, moleküler yanıt, yan etki profili mortalite üzerindeki...