A5020337751- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Glioma Diagnosis and Treatment
- BRCA gene mutations in cancer
- MicroRNA in disease regulation
- Diet and metabolism studies
- Diabetes Management and Research
- Virus-based gene therapy research
- Plant tissue culture and regeneration
- Prenatal Screening and Diagnostics
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- Nematode management and characterization studies
- Stress Responses and Cortisol
- Diabetes Management and Education
- Histiocytic Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Engine and Fuel Emissions
- Circular RNAs in diseases
- Technical Engine Diagnostics and Monitoring
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Proteoglycans and glycosaminoglycans research
- Gut microbiota and health
University College London
2020-2025
CRUK Lung Cancer Centre of Excellence
2021-2025
London Cancer
2022
Leicester General Hospital
2022
Imperial College London
2012-2017
MRC London Institute of Medical Sciences
2017
London School of Hygiene & Tropical Medicine
1997-2016
University of London
2015
Mental Health Research Institute
2011-2012
The University of Melbourne
2011-2012
The gut hormones peptide YY (PYY) and glucagon-like 1 (GLP-1) acutely suppress appetite. short chain fatty acid (SCFA) receptor, free receptor 2 (FFA2) is present on colonic enteroendocrine L cells, a role has been suggested for SCFAs in appetite regulation. Here, we characterise the vitro vivo effects of propionate PYY GLP-1 release rodents, investigate FFA2 mediating these using knockout mice.We used Wistar rats, C57BL6 mice (FFA(-/-)) background to explore impact SCFA release. Isolated...
Epstein-Barr virus (EBV) genome-positive nasopharyngeal carcinomas (NPCs) regularly express the virus-coded nuclear antigen EBNA1, but not other EBNAs, and a subset of tumors also appear to be latent membrane protein LMP1 positive; status NPCs with respect second LMP2 is unknown. In present work EBV-NPC cell interaction has been analyzed at RNA level reverse transcription polymerase chain reaction-based amplification detect specific viral mRNAs. All four transplantable NPC lines studied 17...
Epstein-Barr virus (EBV) is associated with a number of different human tumors and appears to play pathogenetic roles in each case. Thus, immunoblastic B cell lymphomas the immunosuppressed display full pattern EBV latent gene expression (expressing nuclear antigen [EBNA]1, 2, 3A, 3B, 3C, -LP, membrane protein [LMP]1, 2A, 2B), just as do lymphoblastoid lines transformed by vitro. In contrast, those EBV-associated more complex, multistep pathogenesis show restricted patterns viral expression,...
Dietary supplementation with fermentable carbohydrate protects against body weight gain. Fermentation by the resident gut microbiota produces short-chain fatty acids, which act at free acid receptor 2 (FFAR2). Our aim was to test hypothesis that FFAR2 is important in regulating beneficial effects of on and understand role hormones PYY GLP-1. Wild-type or Ffar2−/− mice were fed an inulin supplemented control diet. Mice metabolically characterized hormone concentrations, enteroendocrine cell...
Abstract Glioblastomas are hierarchically organised tumours driven by glioma stem cells that retain partial differentiation potential. Glioma maintained in specialised microenvironments, but whether, or how, they undergo lineage progression outside of these niches remains unclear. Here we identify the white matter as a differentiative niche for glioblastomas with oligodendrocyte competency. Tumour contact acquire pre-oligodendrocyte fate, resulting decreased proliferation and invasion....
Glioblastoma (GBM) recurrence originates from invasive margin cells that escape surgical debulking, but to what extent these resemble their bulk counterparts remains unclear. Here, we generated three immunocompetent somatic GBM mouse models, driven by subtype-associated mutations, compare matched and cells. We find that, regardless of tumors converge on common sets neural-like cellular states. However, have distinct biology. Injury-like programs associated with immune infiltration dominate...
Epstein-Barr virus (EBV) expresses six nuclear antigens (EBNAs) and three integral latent membrane proteins (LMPs) in latently infected growth-transformed B lymphoblastoid cell lines (LCLs). In contrast, EBV protein expression Burkitt lymphoma tissue or newly established is frequently restricted to the genome maintenance protein, EBNA-1. EBNA-1 absence of other EBNAs LMP-1 has been an enigma since, LCLs, all EBNA mRNAs are processed from a single transcript. We now show that basis for cells...
The aim of this multi-centre UK study is to examine the attributes a cohort offered predictive genetic testing for breast/ovarian cancer predisposition. Participants are adults unaffected with from families known BRCA1/2 mutation. This first large population in UK. evaluates mental health, perceived risk developing cancer, preferred management options, and motivation testing. were assessed when coming forward counselling prior proceeding Three hundred twelve individuals, 76% whom female,...
BRCA1/2 test decliners/deferrers have received almost no attention in the literature and this is first study of population United Kingdom. The aim multicenter to examine attributes a group individuals offered predictive genetic testing for breast/ovarian cancer predisposition who did not wish proceed with at time entry into study. This forms part larger involving 9 U.K. centers investigating psychosocial impact BRCA1/2. Cancer worry reasons declining or deferring were evaluated by...
Introduction Type 1 diabetes (T1D) in children and adolescents is increasing worldwide with a particular increase <5 years. Fewer than 6 achieve recommended glycated hemoglobin (HbA1c) values. Methods A pragmatic, cluster-randomized controlled trial assessed the efficacy of clinic-based structured educational group incorporating psychological approaches to improve long-term glycemic control, quality life psychosocial functioning T1D. 28 pediatric services were randomized deliver...
Abstract Glioblastoma (GBM) is the most common and aggressive brain tumour with stark resistance to available therapies, leading relapse a median survival of &lt;15 months. A key cause therapy diffuse infiltration cells into regions surrounding tumour, which presents major clinical challenge as existing imaging techniques offer limited detection resectable margin. Here, we use diffusion weighted (DWI) apply multiple echo time neurite orientation dispersion density (MTE-NODDI) model tool...
Background There is recognition of an urgent need for clinic-based interventions young people with type 1 diabetes mellitus that improve glycemic control and quality life. The Child Adolescent Structured Competencies Approach to Diabetes Education (CASCADE) a structured educational group program, using psychological techniques, delivered primarily by nurses. Composed four modules, it designed children poor diabetic their parents. A mixed methods process evaluation, embedded within cluster...
Introduction Antiretroviral therapy has improved the health of people living with HIV (PLW-HIV), though less is known about how this impacts on acute respiratory illness. These illnesses are a common cause ill in general population and any increase their frequency or severity PLW-HIV might have significant implications for health-related quality life development chronic disease. Methods In prospective observational cohort study following negative participants 12 months weekly documentation...