A5023508387- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Impact and Responses
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- Global Maternal and Child Health
- Chronic Disease Management Strategies
- Sex work and related issues
- Healthcare innovation and challenges
- Tuberculosis Research and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Breast Cancer Treatment Studies
- Primary Care and Health Outcomes
- Healthcare Policy and Management
- Psychiatric care and mental health services
- Food Security and Health in Diverse Populations
- Heart Failure Treatment and Management
- Global Health Care Issues
- Clinical practice guidelines implementation
- Pharmaceutical Economics and Policy
- Global Public Health Policies and Epidemiology
- Mental Health and Psychiatry
London School of Hygiene & Tropical Medicine
2010-2023
Brandenburg University of Applied Sciences
2017-2022
Faculty of Public Health
2021-2022
Research Institute for Tropical Medicine
2021
Joint United Nations Programme on HIV/AIDS
2008-2019
University of Guyana
2016-2018
Chelsea and Westminster Hospital
1999-2012
University of London
2012
McGill University
2000-2007
World Health Organization
2006
Background The increasing numbers of people living with HIV (PLHIV) who are receiving antiretroviral therapy (ART) have near normal life-expectancy, resulting in more over the age 50 years (PLHIV50+). Estimates number PLHIV50+ needed for development tailored therapeutic and prevention interventions at country, regional global level. Methods AIDS Impact Module Spectrum software was used to compute PLHIV, new infections, AIDS-related deaths 2000–2016. Projections until 2020 were calculated...
The prevalence of respiratory symptoms, atopic sensitization and bronchial hyperresponsiveness was compared in a random sample adults, 20-44 yrs age, two cities West East Germany, Hamburg Erfurt, respectively. There were much higher levels outdoor air pollution due to sulphur dioxide suspended particulates major differences living conditions during the last 40 yrs. Within European Respiratory Health Survey, short questionnaire answered by 3,156 (80% response rate) subjects 3,272 (74%)...
OBJECTIVE--To study the changes in morbidity, mortality, and survival patterns a population of patients with AIDS United Kingdom from 1982 to 1989. DESIGN--A retrospective analysis inpatient outpatient records AIDS. SUBJECTS--347 Patients AIDS, predominantly homosexual or bisexual men. SETTING--Departments immunology genitourinary medicine, St Mary9s Hospital, London. MAIN OUTCOME MEASURES--Presenting diagnosis occurrence other opportunist diseases, cause death, since was diagnosed,...
Background Little information exists on the impact of highly active antiretroviral therapy (HAART) health-care provision in South Africa despite increasing scale-up access to HAART and gradual reduction prices. Methods Findings Use cost services for 265 HIV-infected adults without AIDS (World Health Organization [WHO] stage 1, 2, or 3) 27 with (WHO 4) receiving between 1995 2000 Cape Town were compared controls matched baseline WHO stage, CD4 count, age, socioeconomic status, who did not...
Many resource-limited countries are scaling up health services and health-information systems (HISs). The HIV Cascade framework aims to link treatment programs improve outcomes impact. It has been adapted prevention services, other infectious non-communicable diseases, for specific populations. Where successful, it links the use of by individuals across different disease categories, time space. This allows development longitudinal records de-identified individual level information is used...
BackgroundAs increasing amounts of personal information are being collected through a plethora electronic modalities by statutory and non-statutory organizations, ensuring the confidentiality security such has become major issue globally. While use many these media can be beneficial to individuals or populations, they also open abuse organizations. Recent examples include collection national systems development programs like Chinese Social Credit System. In low- middle-income countries, an...
Aims: To investigate the existence of national adult antiretroviral therapy (ART) guidelines in 43 World Health Organization (WHO) '3 by 5' focus countries and compare their content with 2003 WHO ART guidelines. Methods: Questionnaires covered initiation ART, selection first or second-line monitoring treatment response toxicity dissemination Weighted concordance scores were created country correlated indicators recommendations. Results: Thirty-nine (91%) returned questionnaires, three which...
Aim To calculate use, cost and cost-effectiveness of people living with HIV (PLHIV) starting routine treatment care before combination antiretroviral therapy (cART) PLHIV first-line 2NRTIs+NNRTI or 2NRTIs+PIboosted, comparing CD4≤200 cells/mm3 CD4>200 cells/mm3. Few studies have calculated the cART above below CD4 200 Methods Use, costs were for in pre-cART cART, (2008 UK prices). Results naïve patients had an annual £6,407 (95%CI £6,382 to £6,425) PPY compared £2,758 £2,752 £2,761) those...
In many high-income countries with low HIV prevalence, significant numbers of persons living (PLHIV) remain undiagnosed. Identification PLHIV via testing offers timely access to lifesaving antiretroviral therapy (ART) and decreases transmission. We estimated the effectiveness cost-effectiveness in United Kingdom (UK), where 25% are be undiagnosed.We developed a dynamic compartmental model analyze strategies expand treatment UK, particular focus on men who have sex (MSM), people inject drugs...
To estimate the cost effectiveness of universal, voluntary HIV screening pregnant women in England.Cost analysis. Cost estimates caring for positive children were based on stage infection and calculated using data obtained from a London hospital between 1986 1996. These combined with health benefits costs antenatal so that England could be estimated.Lifetime, direct medical care childhood infection; life years gained as result programme; net per year different pretest counselling costs;...
The aim of this study was to assess the correlation and average cost total lymphocyte count compared with CD4 as a broad estimate immunosuppression in HIV-1 infected individuals. Spearman's partial rank were calculated between count, absolute per cent stratified by stage infection for routinely collected samples. Data prospectively from T cell-subset register combined clinical data obtained retrospectively case notes HIV-infected patients managed at St Mary's Hospital, London 1982-1991....
Background The number of people living with HIV (PLHIV) is increasing in the UK. This study estimated annual population cost providing services UK, 1997–2006 and projected them 2007–2013. Methods Annual treatment for PLHIV by stage infection type ART was calculated (UK pounds, 2006 prices). Population costs were derived multiplying their Results Average across all stages ranged from £17,034 1997 to £18,087 on mono-therapy £27,649 £32,322 those quadruple-or-more ART. using NHS rose 16,075...
Define and identify long-term non-progressors (LTNP) HIV controllers (HIC), estimate time until disease progression. LTNP are HIV-1+ patients who maintain stable CD4+ T-cell counts, with no history of opportunistic infection or antiretroviral therapy (ART). HIC a subset additionally have undetectable viraemia. These individuals may provide insights for prophylactic therapeutic development. Records attending Chelsea Westminster Hospital (1988–2010), were analysed. defined as: >7 years;...
Between 2000 and 2015, the number of people newly infected with HIV in Caribbean decreased by 76% HIV-related deaths 42%. The living (PLHIV) on anti-retroviral therapy (ART) increased from near zero to 50% (44% 57%) 2015. In many countries communities men-who-have-sex-with-other-men (MSM) have higher incidence prevalence HIV. They are often stigmatized subjected both social institutional discrimination. This study compared attitudes general public obtained through opinion polls 2013-2014...
Objective: To investigate the relationship between changing morbidity patterns, use of hospital services by HIV-infected patients and uptake antiretroviral therapy (ART) in England. Design: Prospective serial cross-sectional analyses based on data collected through National Monitoring System (NPMS), a multi-centre prospective monitoring system. Setting: seen 10 clinics, five London non-London, during three semesters, 1 January 1996 to 30 June 1997. Main outcome measures: The mean per...
Aim Investigate the cost and effects of a single-pill versus two- or three pill first-line antiretroviral combinations in reducing viral load, increasing CD4 counts, failure rate associated with respective regimens at 6 12 months. Methods Patients on TDF+3TC+EFV, TDF+FTC+EFV, Truvada®+EFV Atripla® between 1996–2008 were identified load counts measured baseline, six twelve months respectively. Factors that independently predicted treatment derived using multivariate Cox's proportional hazard...