A series of molecules containing acetylphenoxymethyl, triazole, and N ‐phenylacetamide moieties were synthesized via the click chemistry approach. All compounds screened for their antimicrobial activities in vitro . The 8a , 8b 8m 8n showed better activities. We further performed exploratory docking studies to gain some insight regarding molecular mechanism antibacterial action these that could guide structure‐activity relationship (SAR) studies. examined interaction most active compound...

Abstract In the present study, a series of new isoniazid‐1,2,3‐triazole conjugates ( 5a‐k ) was synthesized via click chemistry approach. The newly compounds were assessed for their in vitro antitubercular and antimicrobial activities. compound 5g has displayed potent activity against Mycobacterium tuberculosis H37Rv Mtb with MIC value 1.56 μg/mL. active screened cytotoxicity profile by MTT assay RAW 264.7 cell line. four have shown good activities both antibacterial antifungal pathogens. A...

The detergent-compatible alkaline protease was produced from the bacterial strain Bacillus sp. APP-07 isolated Laundromat soil of Solapur, Maharashtra, India. culture grown in 1000 ml capacity baffled flask with a working volume 100 and incubated at 55 °C for 33 h on rotary shaker. After incubation, partially purified by sequential method acetone precipitation followed nominal molecular weight limit (NMWL) cut-off ultrafiltration using 50 K 10 filters. Finally, Sephadex G-100 gel filtration...

In the present study, substituted formylnaphthalenyloxymethyl‐triazolyl‐ N ‐phenylacetamide derivatives ( 6a – k ) have been designed and synthesized employing click chemistry approach evaluated for their in vitro antifungal antibacterial activities. All newly compounds were thoroughly characterized by 1 H NMR, 13 C HRMS spectral techniques. Among screened compounds, 6d , 6e 6j 6k shown good Compound has very effective antimicrobial activity. We further performed exploratory docking studies...

Abstract A series of novel substituted ( E )‐ N ′‐benzylidene‐4‐methyl‐2‐(2‐propylpyridin‐4‐yl)thiazole‐5‐carbohydrazide derivatives 6a‐l ) have been synthesized by following the multistep synthetic route starting from prothionamide. The resulting compounds were characterized via 1 H, 13 C NMR, and HRMS spectral data. carbohydrazides evaluated for their in vitro antimicrobial antioxidant activities. Tested molecules displayed moderate to good growth inhibition activity. Among screened...

The purpose of the present study was to check whether light is an inducing agent or not for intracellular and extracellular pigment production by Pseudomonas aeruginosa NR1? Is produced a photoprotective in nature? aim research evaluate influence different wavelengths, intensity, temperature, pH on biomass production. A strain that thermoalkalophilic produces red non-diffusible green-diffusible isolated, until now no one has reported this type strain. For determining effect we introduced...

Abstract In search of new anticancer and antimicrobial agents, herein we report the synthesis substituted ( E )‐ N ′‐benzylidene‐2‐(2‐ethylpyridin‐4‐yl)‐4‐methyl thiazole‐5‐carbohydrazide derivatives 6 a‐n ), starting from ethionamide. The newly synthesized compounds were characterized by 1 H NMR, 13 C NMR HRMS analyses. All have been evaluated for their activity. Among fourteen compounds, five carbohydrazide displayed more promising activity against lung carcinoma A‐549 cells. Also, these...

A series of new hydrazones bearing pyridyl and thiazolyl scaffolds have been synthesized evaluated for their in vitro anticancer antimicrobial activities. The activity was against the A549 lung cancer cell line. eight hydrazone derivatives shown better than positive control doxorubicin bacterial fungal pathogens by using well diffusion method. four displayed good Molecular docking studies revealed binding via hydrogen bond interactions with key residues on active sites as neighboring an site...

Electrochemical oxidative activation of ethionamide (ETO) on GO (∼500 nm) confirmed by HRMS and FTIR analysis. The ETO-O (oxidized form) showed enhancement in activity over ETO against Gram negative pathogens (<italic>E. aerogenes</italic>,<italic>S. abony</italic>,<italic>S. boydii</italic>,<italic>E. coli</italic>).

Background: Thiosemicarbazone, 1,2,3-triazole and their derivatives received great pharmaceutical importance due to prominent biological activities. In the present study, molecular hybrid thiosemicarbazone-1,2,3-triazoles were synthesized screened for antimicrobial Methods: A series of thiosemicarbazone clubbed with via click chemistry approach in good yields. The structures compounds assigned by spectral data. vitro activity was performed agar well diffusion method. docking study identify...

Diabetes mellitus is a chronic endocrine disorder that affects the metabolism of carbohydrates, proteins, fat, electrolytes and water. α -Amylase -glucosidase are important enzymes required for digestion carbohydrate. These plays vital role in breakdown starch diet its activity has been correlated to postprandial blood glucose levels, control which essential maintaining quality life diabetic patients. We report synthesis, characterization biological evaluation new substituted...

New 1,2,3-triazoles bearing biphenoloxymethyl and acetanilido moieties (5a-5l) have been synthesized, starting from 4-phenylphenol (1) following click chemistry approach. The synthesized compounds thoroughly characterized by their 1H NMR, 13C NMR HRMS spectral data. These were evaluated for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv antimicrobial pathogenic microbia. Among the screened compounds, 5a 5i displayed notable with MIC 25 µg/mL. Compounds 5a, 5b, 5c,...

Objective: The objective of the present study was to synthesize a series some novel (E)-methyl 2,4-dimethyl-5-(3-oxo-3-phenylprop-1-en-1-yl)-1H-pyrrole-3-carboxylate derivatives and evaluate it’s in vitro antimicrobial activities.&#x0D; Methods: A derivative (8a-l) has been synthesized by cyclization (Knorr reaction) hydrolysis, decarboxylation, Vilsmeier–Haack formylation reaction. 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate 6 undergo condensation with acetophenone 7a-l methanol...

Abstract A series of new 2‐(2‐ethylpyridin‐4‐yl)‐4‐methyl‐ N ‐phenylthiazole‐5‐carboxamide derivatives ( 5a‐l ) were synthesized and evaluated for their in vitro antimicrobial activities. Among the screened compounds, 5b , 5d 5e 5f, 5j have shown promising activities against both bacterial fungal pathogens. molecular docking study was conducted to know probable mode action activity. The active compounds excellent binding affinity toward DNA gyrase lumazine synthase enzymes. physicochemical...

In search of a more potent and new series fluorine-containing quinoline, hybrid Schiff bases (6a–o) analogues were synthesized by facile efficient conventional method. They developed via condensation quinoline-4-carbohydrazide intermediate aromatic aldehydes in presence ethanol. All compounds viz., 6a–o efficiently good yields ranges 76–84%, respectively. well characterized using various spectroscopic techniques such as FT-IR, 1H NMR, 13C Mass spectroscopy. Moreover, all newly have been...