A5062524958- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Computational Drug Discovery Methods
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Tuberculosis Research and Epidemiology
- Quinazolinone synthesis and applications
- Natural product bioactivities and synthesis
- HIV/AIDS drug development and treatment
- Synthesis of β-Lactam Compounds
- Synthesis of Tetrazole Derivatives
- Bioactive Compounds and Antitumor Agents
- Curcumin's Biomedical Applications
- Synthesis of heterocyclic compounds
- Ginger and Zingiberaceae research
- Biological Activity of Diterpenoids and Biflavonoids
- Sesquiterpenes and Asteraceae Studies
- Pharmacological Effects of Natural Compounds
- Allelopathy and phytotoxic interactions
- Receptor Mechanisms and Signaling
- Plant biochemistry and biosynthesis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Crystallography and molecular interactions
Vishwakarma University
2020-2025
Savitribai Phule Pune University
2013-2021
Shri Vile Parle Kelavani Mandal
2017-2020
Bombay College of Pharmacy
2008-2019
National Chemical Laboratory
2015-2019
University of KwaZulu-Natal
2015-2018
Virologie et Immunologie Moléculaires
2017-2018
Université Paris-Saclay
2017-2018
Bharati Vidyapeeth Deemed University
2013
Despite intense research efforts towards clinical and molecular causes of Parkinson disease (PD), the etiology still remains unclear. However, recent studies have provided ample evidences that oxidative stress is key player contributes a lot to dopaminergic (DAergic) neurodegeneration in brain. It due discrepancy antioxidant defence system which nuclear factor erythroid 2-related 2 (Nrf2) signalling central contour. In current study, potent heme oxygenase-1 agonists (Nrf2 regulator), vinyl...
We describe the synthesis of novel triazole-incorporated diindolylmethanes (DIMs) using a molecular hybridization approach.
Abstract The design and synthesis of new chemical entities (NCEs) with suitable physicochemical properties are playing a key role in medicinal research areas. Hence, we have designed synthesized the 10 diverse scaffolds by rightly selecting quinoline pyrazine to articulate carboxamide derivatives single‐step process maximum conversation shorter time through studies Ugi multi‐component reaction. Molecular docking against FMS‐like tyrosine kinase‐3 (FLT3) provided well‐clustered solutions for...
Abstract A green and efficient protocol has been developed for the synthesis of novel 1,2,3‐triazole‐chromene conjugates ( 7 a‐j ) via ultrasound assisted NaHCO 3 catalyzed first time. Structures all new were deduced by various spectroscopic techniques. The newly synthesized triazole‐chromene evaluated their in vitro antitubercular activity against Mycobacterium tuberculosis (MTB) H37Rv strain. f h found to be most active with MIC value 12.5 μg/mL. Furthermore, screened antioxidant are...
The present work describes design of a small library new 1,2,3-triazole-appended bis-pyrazoles by using molecular hybridization approach, and the synthesized hybrids were evaluated for their antifungal activity against different fungal strains, namely, Candida albicans, Cryptococcus neoformans, glabrata, tropicalis, Aspergillus niger, fumigatus. All compounds exhibited broad-spectrum tested strains with excellent minimum inhibitory concentration values. docking study sterol 14α-demethylase...
Microwave-assisted organic reaction enhancement (MORE) has become more important in synthetic chemistry for efficient resource utilization. In this study, we synthesized bioactive compounds using both traditional and microwave methods. synthesis takes less time produces higher yields quality than conventional approaches. We reported the of N'-(1-(2-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-oxadiazol-3(2H)-yl)ethylidene) substituted hydrazides (4a-t). also tested them...