A5032720545- Fluoride Effects and Removal
- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Bone and Dental Protein Studies
- Birth, Development, and Health
- Trace Elements in Health
- Renal and related cancers
- Biomarkers in Disease Mechanisms
- Kidney Stones and Urolithiasis Treatments
- Mesenchymal stem cell research
- Anesthesia and Neurotoxicity Research
- Turtle Biology and Conservation
- Pregnancy and preeclampsia studies
- Arsenic contamination and mitigation
- Pharmacological Effects and Toxicity Studies
- Clusterin in disease pathology
- Ichthyology and Marine Biology
- Cancer, Hypoxia, and Metabolism
Instituto Politécnico Nacional
2013-2023
Center for Research and Advanced Studies of the National Polytechnic Institute
2013-2018
Background: The proximal tubule (PT) is the major target of cadmium (Cd2+) nephrotoxicity. Current dogma postulates that Cd2+ complexed to metallothionein (MT) (CdMT) taken up through receptor-mediated endocytosis (RME) via PT receptor megalin:cubilin, which predominant pathway for reuptake filtered proteins in kidney. Nevertheless, there evidence distal parts nephron are also sensitive damage induced by Cd2+. In rodent kidneys, another protein endocytosis, 24p3 (24p3R), exclusively...
Abstract Cadmium is a well‐characterized nephrotoxic agent that also capable of accumulating and diffusing across the placenta; however, only few studies have addressed its effects over fetal kidneys none them has used panel sensitive specific biomarkers for detection kidney injury. The goal this study was to determine cadmium renal in rat fetuses by quantification early injury biomarkers. Pregnant Wistar rats were exposed inhalation an isotonic saline solution or CdCl 2 (D Del =1.48 mg Cd...
During embryonic development, some hypoxia occurs due to incipient vascularization. Under hypoxic conditions, gene expression is mainly controlled by hypoxia-inducible factor 1 (HIF-1). The activity of this transcription can be altered the exposure a variety compounds; among them cadmium (Cd), nephrotoxic heavy metal capable crossing placenta and reaching fetal kidneys. goal study was determine Cd effects on HIF-1 Pregnant Wistar rats were exposed mist isotonic saline solution or CdCl2 (DDel...
Abstract Fluoride is an important groundwater contaminant, and more than 200 million people are exposed to high fluoride levels in drinking water, the major source of exposure. Exposure above 2 ppm associated with renal impairment humans. In rats, moderate induce kidney injury at early stages which glomerular filtration rate (GFR) not altered. present study, we investigated if sub‐nephrotoxic stimulus induced by might impact response a subsequent nephrotoxic treatment gentamicin. Male Wistar...