A5057358757- Hormonal Regulation and Hypertension
- Acute Kidney Injury Research
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Chronic Kidney Disease and Diabetes
- Liver Disease and Transplantation
- Chemotherapy-induced organ toxicity mitigation
- Dialysis and Renal Disease Management
- Heat shock proteins research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug Transport and Resistance Mechanisms
- Diabetes Treatment and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Ion channel regulation and function
- Drug-Induced Hepatotoxicity and Protection
- Birth, Development, and Health
- Chronic Lymphocytic Leukemia Research
- Fluoride Effects and Removal
- Lanthanide and Transition Metal Complexes
- Pregnancy and Medication Impact
- Renal function and acid-base balance
- Vitamin C and Antioxidants Research
Université de Montréal
2022-2025
Hôpital Maisonneuve-Rosemont
2022-2025
Universidad Nacional Autónoma de México
2013-2022
Instituto Nacional de Cardiología
2018-2022
RELX Group (United States)
2018-2019
Centre de Recherche des Cordeliers
2014-2018
Sorbonne Université
2015-2018
Inserm
2014-2018
Université Paris Cité
2016-2018
Délégation Paris 5
2018
Acute kidney injury induced by ischemia/reperfusion (IR) is a frequent complication in hospitalized patients. Mineralocorticoid receptor antagonism has shown to be helpful against renal IR consequences; however, the potential benefit of novel nonsteroidal mineralocorticoid antagonists such as finerenone further explored. In this study, we evaluated efficacy prevent acute and chronic consequences ischemic injury. For study (24 hours), 18 rats were divided into sham, bilateral ischemia 25...
AKI is a frequent complication in hospitalized patients. Unfortunately, there no effective pharmacologic approach for treating or preventing AKI. In rodents, mineralocorticoid receptor (MR) antagonism prevents induced by ischemia-reperfusion (IR). We investigated the specific role of vascular MR mediating IR. also assessed protective effect IR-induced Large White pig, model human mice, deficiency smooth muscle cells (SMCs) protected against kidney IR injury. blockade novel nonsteroidal...
Prophylactic mineralocorticoid receptor (MR) antagonism with spironolactone (Sp) in rats completely prevents renal damage induced by ischemia. Because acute ischemia cannot typically be predicted, this study was designed to investigate whether Sp could prevent injury after an ischemic/reperfusion insult. Six groups of male Wistar were studied: that received a sham abdominal operation (S); underwent 20 min and reperfusion for 24 h (I/R) four treated (20 mg/kg) 0, 3, 6 or 9 As expected, I/R...
AKI is associated with high mortality rates and the development of CKD. Ischemia/reperfusion (IR) an important cause AKI. Unfortunately, there no available pharmacologic approach to prevent or limit renal IR injury in common clinical practice. Renal characterized by diminished nitric oxide bioavailability reduced blood flow; however, mechanisms leading these alterations are poorly understood. In a rat model IR, we investigated whether administration novel nonsteroidal mineralocorticoid...
Acute kidney injury (AKI) is not as harmless previously thought since it may lead to chronic disease (CKD). Because most of the time ischemic AKI occurs unexpectedly, difficult prevent its occurrence and there are no specific therapeutic approaches CKD transition. We aimed determine whether mineralocorticoid receptor blockade (MRB) in first days after ischemia/reperfusion (IR) can progression CKD.Four groups male Wistar rats were included: sham three bilateral renal ischemia for 45 min, one...
Abstract This study was designed to assess whether heat shock protein Hsp72 is an early and sensitive biomarker of acute kidney injury (AKI) as well monitor a renoprotective strategy. Seventy‐two Wistar rats were divided into six groups: sham‐operated subjected 10, 20, 30, 45 60 min bilateral ischemia (I) 24 h reperfusion (R). Different times (3, 6, 9, 12, 18, 24, 48, 72, 96 120 h) also evaluated in 30 other ischemia. messenger RNA (mRNA) levels determined both urine. Hsp72‐specificity the...
<b><i>Background:</i></b> Previous experimental studies from our laboratory have demonstrated that aldosterone plays a central role in renal ischemic processes. This study was designed to evaluate the effect of mineralocorticoid receptor blockade transplant recipients living donors. <b><i>Methods:</i></b> 20 adult kidney donors were included double-blind, randomized, placebo-controlled clinical pilot compared spironolactone and placebo. Placebo...
Aim To determine whether non‐steroidal mineralocorticoid receptor (MR) antagonists oppose metabolic syndrome‐related end‐organ, i.e. cardiac, damage. Materials and methods In Zucker fa/fa rats, a rat model of syndrome, we assessed the effects MR antagonist finerenone (oral 2 mg/kg/day) on left ventricular (LV) function, haemodynamics remodelling (using echocardiography, magnetic resonance imaging biochemical methods). Results Long‐term (90 days) modified neither systolic blood pressure nor...
Background Hypercalciuria can result from activation of the basolateral calcium-sensing receptor (CaSR), which in thick ascending limb Henle's loop controls Ca2+ excretion and NaCl reabsorption response to extracellular However, function CaSR regulation distal convoluted tubule (DCT) is unknown. We hypothesized that this location involved activating thiazide-sensitive cotransporter (NCC) prevent loss.Methods used a combination vitro vivo models examine effects on NCC activity. Because...
Administration of the mineralocorticoid receptor antagonist spironolactone prevents development chronic kidney disease (CKD) after a severe ischemic injury.However, whether brief periods ischemia lead to CKD and administration may be useful therapeutic strategy prevent gradual deterioration structure function remains unexplored.Nineteen male Wistar rats were divided into four groups: that underwent renal bilateral for 10, 20, or 45 min compared with sham operated rats.Additionally, thirteen...
Background and Objectives Acute kidney injury (AKI) complicates the course of disease in critically ill patients. Efforts to change its clinical have failed because fail early detection. This study was designed assess whether heat shock protein (Hsp72) is an sensitive biomarker acute compared with molecule (Kim-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18) biomarkers. Methods A total 56 patients fulfilled inclusion criteria. From these patients, 17 developed...
Major cardiovascular events are a common complication in patients with chronic kidney disease (CKD). Endothelial dysfunction can contribute to the injury observed CKD. Here, we used rat model of acute CKD transition investigate heart alterations pathway activating endothelial nitric oxide synthase (eNOS) and its impact on cardiac during progression. Fifty male Wistar rats were subjected sham surgery (n = 25) or bilateral renal ischemia-reperfusion (IR-CKD) for 45 min 25). Rats studied...
Cisplatin is a chemotherapy drug widely used in the treatment of solid tumors. However, nephrotoxicity has been reported about one-third patients undergoing cisplatin therapy. Proximal tubules are main target toxicity and cellular uptake; elimination this can modulate renal damage. Organic transporters play an important role transport into kidney organic cations transporter 2 (OCT-2) shown to be one most role. On other hand, multidrug toxin extrusion 1 (MATE-1) protein that mediates urine....