A5041643798- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Amyotrophic Lateral Sclerosis Research
- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neuroscience of respiration and sleep
- Alzheimer's disease research and treatments
- Obesity, Physical Activity, Diet
- EEG and Brain-Computer Interfaces
- Psychosomatic Disorders and Their Treatments
- Neural dynamics and brain function
- Attention Deficit Hyperactivity Disorder
- Radiomics and Machine Learning in Medical Imaging
- Mind wandering and attention
- Nutrition and Health in Aging
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Obstructive Sleep Apnea Research
- Transcranial Magnetic Stimulation Studies
- Children's Physical and Motor Development
- Peripheral Neuropathies and Disorders
University of Bari Aldo Moro
2021-2025
University for Foreigners Perugia
2024-2025
Don Carlo Gnocchi Foundation
2023
University of Bologna
2014-2022
University of Modena and Reggio Emilia
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2020
Istituto delle Scienze Neurologiche di Bologna
2020
University of Verona
2020
University of Parma
2020
Institute of Neurological Sciences
2020
Diagnostic incidence data for syndromes associated with frontotemporal lobar degeneration (FTLD) in multinational studies are urgent light of upcoming therapeutic approaches.To assess the FTLD across Europe.The Frontotemporal Dementia Incidence European Research Study (FRONTIERS) was a retrospective cohort study conducted from June 1, 2018, to May 31, 2019, using population-based registry 13 tertiary research clinics UK, Netherlands, Finland, Sweden, Spain, Bulgaria, Serbia, Germany, and...
Abstract INTRODUCTION Sleep and rest–activity rhythm alterations are common in neurodegenerative diseases. However, their characterization patients with behavioral variant frontotemporal dementia (bvFTD) has proven elusive. We investigated alterations, sleep disturbances, neural correlates bvFTD. METHODS Twenty‐seven bvFTD 25 healthy controls completed questionnaires underwent 7 days of actigraphy while concurrently maintaining a diary. Cortical complexity thickness were calculated from...
Type 1 narcolepsy is a central hypersomnia due to the loss of hypocretin-producing neurons and characterized by cataplexy, excessive daytime sleepiness, sleep paralysis, hypnagogic hallucinations disturbed nocturnal sleep. In children, close disease onset, type has peculiar clinical features with severe cataplexy complex admixture movement disorders occurring while awake. Motor dyscontrol during never been systematically investigated. Suspecting that abnormal motor control might affect also...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, mostly prominent in the domain of memory, but also associated with other deficits and non-cognitive symptoms. Reduced muscle strength common AD. However, current understanding its relationship decline limited. This study investigates between cognition patients AD mild impairment (MCI). We enrolled 148 consecutive subjects, including 74 probable dementia, 37 MCI, controls. Participants...
To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared 17 RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin was positive in 86.7% of iRBD none narcoleptic patients. The analysis video-polysomnographic motor events showed differences their occurrence throughout the night two...
Abstract An increasing number of sleep applications are currently available and being widely used for in‐home tracking. The present study assessed four smartphone (Sleep Cycle‐Accelerometer, SCa ; Sleep Cycle‐Microphone, SCm Sense, Se Smart Alarm, SA ) designed sleep−wake detection through sound movement sensors, by comparing their performance with polysomnography. Twenty‐one healthy participants (six males, 15 females) the running on iPhone (provided experimenter) simultaneously portable...
Background Attentional complaints are common in narcolepsy patients and can overlap with daytime sleepiness features. Few studies attempted to characterize attentional domains leading controversial results. We aimed assess the impact of hypocretin deficiency on functioning by comparing performances attention network test (ANT) narcoleptic (narcolepsy type 1—NT1) versus without 2—NT2) healthy controls. also addressed frequency severity psychopathological symptoms their influence ANT. Methods...
Objectives: Regular physical activity is routinely recommended in children and adolescents suffering from narcolepsy type 1 (NT1), but controlled studies analyzing its influence on sleep/wake behavior, metabolic anthropometric profile pediatric NT1 are lacking. Methods: Fifty consecutive drug-naïve were assessed through actigraphic, clinical, evaluations. Patients compared with respect to their engagement leisure-time activities (LTPA): patients engaged LTPA (n=30) not (No-LTPA, n=20),...
Network modeling is increasingly used to study brain alterations in neurological disorders. In this study, we apply a novel approach based on the similarity of regional radiomics feature characterize gray matter network changes patients with behavioral variant frontotemporal dementia (bvFTD) using MRI data. cross-sectional assessed structural 3 T data from twenty bvFTD and 20 cognitively normal controls. Radiomics features were extracted T1-weighted cortical subcortical segmentation....
The current study was conducted to provide normative data on actigraphic dichotomy index (I < O) (the percentage of in bed activity counts that are less than the median out counts) healthy population and assess whether I O could be an effective discriminating circadian motor cancer patients from controls. In this retrospective study, we recovered 408 records two databases: controls (n = 182; 79 males; mean age 38.7 ± 12.6) with metastatic colorectal 226; 149 58.4 11.4). Beside usual sleep...
Sodium oxybate (SXB) is a GABAergic agent widely used as off-label treatment in pediatric type 1 narcolepsy (NT1). Here, we aimed at analyzing by wrist actigraphy the sleep/wake profile of NT1 children and adolescents drug-naïve condition after year SXB treatment. As secondary aim, investigated changes on sleepiness, cataplexy, children's anthropometric Twenty-four underwent 7 days during school week. Information symptoms, features were collected same week with questionnaires semistructured...
Pediatric type 1 narcolepsy is often challenging to diagnose and remains largely undiagnosed. Excessive daytime sleepiness, disrupted nocturnal sleep, a peculiar phenotype of cataplexy are the prominent features. The knowledge available about regulation circadian rhythms in affected children scarce. This study compared rest-activity rhythm actigraphic estimated sleep measures with versus healthy controls. Twenty-two drug-naïve 21 age- sex- matched controls were monitored for seven days...
Abstract Study Objectives Narcolepsy type 1 (NT1) is a chronic rare hypersomnia of central origin requiring combination behavioral and pharmacological treatments. During the coronavirus disease 2019 (COVID‐19) pandemic, in Italy population was forced into lockdown. With this study, we aimed to describe lockdown impact on NT1 symptom management, according different patients' working schedule. Methods In period between 10 April 15 May 2020, performed routine follow‐up visits by telephone (as...
Study Objectives: Narcolepsy type 1 (NT1) is a chronic neurological disorder typically arising during adolescence and young adulthood.Recent studies demonstrated that NT1 presents with age-specific features, especially in children.With this study we aimed to describe compare the clinical pictures of different age groups.Methods: In cross-sectional, multicenter study, 106 untreated patients enrolled at time diagnosis underwent evaluation, semistructured interview (including Epworth Sleepiness...
"Just Accepted" papers have undergone full peer review and been accepted for publication in Radiology: Artificial Intelligence. This article will undergo copyediting, layout, proof before it is published its final version. Please note that during production of the copyedited article, errors may be discovered which could affect content. Purpose To develop a fast fully automated deep learning (DL)-based method MRI planimetric segmentation measurement brainstem ventricular structures most...
Abstract Harmonized neuropsychological assessment for neurocognitive disorders (NCDs) is an urgent priority in clinics. Neuropsychology assessments NCDs seldom include tests exploring social cognitive skills. In 2022, we launched the SIGNATURE initiative to optimize socio‐cognitive NCDs. Here, report findings from first phase, including consortium creation and evaluation of state art memory We developed ad hoc online survey explore practices measures, relevance, obstacles preventing use...