Alkylation of indoles by means the Michael addition has been subject a number investigation. It is well established that regioselectivity in additions to electron-deficient alkenes strongly controlled reaction medium. In continuation work on developing greener and cleaner technologies, cerium(III) chloride heptahydrate sodium iodide combination supported silica gel catalyzes alkylation various with alpha,beta-unsaturated ketones giving 3-(3-oxoalkyl)indole derivatives good yields. The...

The combination of cerium(III) chloride heptahydrate and sodium iodide supported on silica gel is known to promote Michael-type additions. Continuing our work solvent-free conditions, the CeCl3·7H2O−NaI−SiO2 system catalyzes addition a variety indoles nitroalkenes, giving 2-indolyl-1-nitroalkane derivatives in good yields. Development this method has resulted new protocol for synthesis 4-substituted β-carbolines.

Conjugate addition of heteroatom nucleophiles to carbon-carbon double bonds conjugated with a strong electron-withdrawing group is one the most important new bond-forming strategies in synthetic organic chemistry. Among methods for these Michael additions, Lewis acids have shown best promoter activity, and particular, use reagents impregnated over inorganic supports rapidly increased. With increase environmental consciousness chemical research, solvent-free has attracted our attention. In...

The Lewis acid promoted allylation of aldehydes has become an important carbon−carbon bond forming reaction in organic chemistry. In this context, we have developed alternative over existing catalytic processes, wherein are subject acetonitrile to with allyltributylstannane the presence 1.0 equiv cerium(III) chloride heptahydrate (CeCl3·7H2O), inexpensive and mild acid. been accelerated by using inorganic iodide as a cocatalyst, various salts were examined. procedure must use allylstannane...

2-Alkylidenecycloalkanones are powerful synthons used as the key intermediates in many important syntheses. Because of their potential, a general method preparation from readily available starting materials, under very mild conditions, was considered to be worthwhile. Cerium(III) chloride heptahydrate combination with sodium iodide refluxing acetonitrile promotes regio- and stereoselective β-elimination reaction (E)-2-alkylidenecycloalkanones 2-(1-hydroxyalkyl)cycloalkanones. The synthetic...

Abstract A high stereochemical induction has often been observed in the reduction of ketones with stereogenic centres close to carbonyl function. The level stereoselectivity is particularly when “hard” donor groups such as nitrogen or oxygen atoms are present molecule. These results have commonly explained terms a chelate‐controlled process. However, this interpretation recently challenged, and many cases an open‐chain mechanism can better account for results. Thus, Lewis‐acid‐mediated...

Abstract The cerium(III) chloride heptahydrate/sodium iodide complex (CeCl 3 ⋅ 7 H 2 O/NaI) acts as a useful promoter in the carbon‐carbon bond forming reaction by addition of allyltributylstannanes to aldehydes. 2‐butenyltributylstannane shows that regio‐ and stereochemical outcomes depend on conditions. When is adsorbed solid support (aluminum oxide), highly prevalent formation γ‐adduct observed solvent‐free Conversely, when carried out acetonitrile solvent, α‐adduct largely prevails. In...

Abstract An efficient and highly chemoselective method fo the protection of free hydroxy compounds with 3,4‐dihydro‐2 H ‐pyran is reported. Since deprotection THP‐ethers occurs very readily at room temperature, successful use this type protecting group depends only upon how it can be introduced. For we have examined tetrahydropyranylation alcohols phenols catalysed by CeCl 3 · 7 2 O/NaI system surface under solvent‐free conditions. The reaction presents advantage being performable extremely...

Among many, poly(lactic acid) (PLA) has received significant consideration. The striking price and accessibility of l-lactic acid, as a naturally occurring organic are important reasons for poly-(l)-lactic acid (PLLA) improvement. PLLA is compostable biocompatible/bioresorbable polymer used disposable products, biomedical applications, packaging film, in the automotive industry, electronic device components, many other applications. Formerly, titanium metals have been different orthopaedic...

THE FUNCTION OF INSTRUCTIONAL TOOLS ON STUDENTS’ DISTRIBUTED LEADERSHIP DEVELOPMENT: AN EXPLORATORY RESEARCH IN ITALIAN ACADEMIC CONTEXT

Efficient electrophilic substitution reactions of indoles with various carbonyl compounds proceed easily in solvent-free conditions using CeCl3·7H2O-NaI-SiO2 system promoter, to afford the corresponding bis(1H-indol-3-yl)alkanes high yields. The synthetic value present procedure is demonstrated by synthesis streptindole (9), human intestinal bacteria metabolite.

THE GIFTEDNESS AS A SPECIAL EDUCATIONAL NEED: DEVELOPMENT TRAJECTORIES AND PROFESSIONAL PRACTICES IN ITALIAN SCHOOL

LEADERSHIP PRACTICES AND MIDDLE MANAGEMENT AS RESOURCES TO QUALIFY TEACHERS' PROFESSIONAL EXPERIENCES: A CASE STUDY

Appears in: INTED2017 Proceedings Publication year: 2017Pages: 305-313ISBN: 978-84-617-8491-2ISSN: 2340-1079doi: 10.21125/inted.2017.0200Conference name: 11th International Technology, Education and Development ConferenceDates: 6-8 March, 2017Location: Valencia, Spain

The manufacturing industry is being benefited from the new technologies developed in field of artificial intelligence.However, as part European AI strategy, role workers must be protected by including human-centered ethical values.The TEAMING.AI project developing a revolutionary human-AI teaming software platform comprised interconnected utilities.This work reflects preliminary results some methodologies that are within project.An ergonomics assessment manual activities performed operators...