A5072158873- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Neuroblastoma Research and Treatments
- Testicular diseases and treatments
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Neonatal Health and Biochemistry
- Erythrocyte Function and Pathophysiology
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Vascular Malformations and Hemangiomas
- Hemoglobinopathies and Related Disorders
- Fungal Infections and Studies
- Epigenetics and DNA Methylation
- Cytomegalovirus and herpesvirus research
- Gestational Trophoblastic Disease Studies
- Adolescent and Pediatric Healthcare
- Retinoids in leukemia and cellular processes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Brain Metastases and Treatment
Mackay Memorial Hospital
2016-2025
Mackay Medical College
2016-2025
Chang Gung Memorial Hospital
2004-2024
Mackay Junior College of Medicine, Nursing and Management
2007-2014
Taipei Medical University
2007-2011
Taipei Institute of Pathology
2007
St. Jude Children's Research Hospital
2003-2004
NewYork–Presbyterian Hospital
2000-2001
Cornell University
2000-2001
University Medical Center
2000
PURPOSE We determined the prognostic factors and utility of allogeneic hematopoietic cell transplantation among children with newly diagnosed hypodiploid acute lymphoblastic leukemia (ALL) treated in contemporary clinical trials. PATIENTS AND METHODS This retrospective study collected data on 306 patients ALL who were enrolled protocols 16 cooperative groups or institutions between 1997 2013. The biologic characteristics, early therapeutic responses as by minimal residual disease (MRD)...
Abstract BACKGROUND It is believed that Ras mutations drive the proliferation of leukemic cells. The objective this study was to investigate association with childhood acute lymphoblastic leukemia (ALL) and myeloid (AML) special reference presence or absence mixed‐lineage gene ( MLL ) rearrangements. METHODS Bone marrow samples from 313 children B‐precursor ALL 130 de novo AML were studied at diagnosis. Southern blot analysis used detect rearrangements, reverse transcriptase‐polymerase chain...
The purpose of the current study was to prevent bloodstream infection and invasive fungal (IFI) by administering prophylactic antibiotic antifungal agents during intensive chemotherapy in patients being treated for acute leukemia.Prophylaxis treatment administered children with myeloid leukemia (AML) lymphoblastic (ALL) from January 1, 2010 December 31, 2012. Oral ciprofloxacin (at a dose 300 mg/m(2) /12 hours) after when patient AML or ALL became neutropenic > 7 days neutropenia expected....
Purpose To eliminate the toxicities and sequelae of cranial irradiation (CrRT) to minimize adverse impact traumatic lumbar puncture (TLP) with blasts, a prospective study modified CNS-directed therapy was conducted in children acute lymphoblastic leukemia (ALL). Patients Methods Since June 1999, newly diagnosed ALL have been treated triple intrathecal (TIT) alone without CrRT. The first TIT delayed until disappearance blasts from peripheral blood (PB) for up 10 days multidrug induction, CrRT...
Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in approximately 20% adult acute myeloid leukemia (AML) cases and associated with a poor outcome. However, there are few studies on FLT3/ITD childhood AML, clinical significance is thus unclear.FLT3/ITD analyzed 80 children de novo AML. The genomic DNA polymerase chain reaction (PCR) assay performed to identify FLT3/ITD. Genescan analysis determine allelic distribution then for those PCR products aberrant bands....
Deferoxamine is a chelating agent that has extended the life expectancy of patients with thalassemia. In 1980s, many investigators reported otologic and visual toxicity caused by deferoxamine. July 1999 2 years later, authors performed audiologic ophthalmologic assessments in 30 transfusion-dependent receiving deferoxamine therapy (40-50 mg/kg per dose, subcutaneously for 8-10 hours, 4-7 days week). 1999, six (20%) had deferoxamine-related hearing impairment (>25 dB), all at high...
Background To eliminate cranial irradiation (CrRT)–related sequelae and to minimize the adverse impact of traumatic lumbar puncture (TLP) with blasts, Taiwan Pediatric Oncology Group (TPOG) introduced a modified central nervous system (CNS)–directed regimen characterized by delayed triple intrathecal therapy (TIT) omission CrRT for all children newly diagnosed acute lymphoblastic leukemia (ALL). Methods This study compared treatment outcomes patients overall non–CNS‐1 status (CNS‐2, CNS‐3,...
Summary This study investigates the potential utility of IKZF1 deletion as an additional high‐risk marker for paediatric acute lymphoblastic leukaemia (ALL). The prognostic impact status, in conjunction with minimal/measurable residual disease (MRD), was evaluated within MRD‐guided TPOG‐ALL‐2013 protocol using 412 newly diagnosed B‐ALL patients aged 1–18. status determined multiplex ligation‐dependent probe amplification. deletions, when co‐occurring CDKN2A , CDKN2B PAX5 or PAR1 region...
Unconventional genetic subtypes of B-cell precursor acute lymphoblastic leukaemia (B-ALL) were analysed to compare their frequency and impact on outcomes between children young adults in Taiwan. found 23.0% 456 paediatric B-ALL 24.5% 139 adult B-ALL. The most frequently unconventional subtype both was BCR::ABL1-like, which could be subdivided into different kinase-altering aberrations 67.3% 78.6% adults. CRLF2-R more frequent children, while IL7R mutations common In favourable observed...
Introduction Myocardial iron overload leading to congestive heart failure (HF) or arrhythmias is a recognized complication in thalassemia patients undergoing chronic blood transfusion. The relationship between myocardial load, subclinical systolic dysfunction, and clinical events remains less well known. Materials Methods We studied total of 77 subjects, comprising 37 (mean age: 24.2 ± 5.5 years) with history repeated transfusions, addition 40 age‐ gender‐matched controls 24 4.5 years)....
Abstract Background We aimed to investigate the frequencies and association with genetic/cytogenetic abnormalities as well prognostic relevance of RAS pathway mutations in Taiwanese children B‐precursor acute lymphoblastic leukemia (ALL), largest cohort Asians. Procedure Between 1995 2012, marrow samples at diagnosis from 535 were studied for NRAS , KRAS PTPN11 mutations. The mutational status each gene was correlated clinico‐hematological features, recurrent genetic abnormalities, outcomes...
Abstract Background The leukemogenesis of T‐cell acute lymphoblastic leukemia (T‐ALL) involves multistep processes genetic alterations. We aimed to determine the alterations including common fusion transcripts, overexpression transcription factor oncogenes, and deletion or mutation targeted genes in pediatric T‐ALL Taiwan as well their impact on outcomes those treated with Pediatric Oncology Group‐ALL‐2002 protocol. Procedure Between 1995 2015, bone marrow samples obtained from 102 children...
Background Discontinuation of E. coli l ‐asparaginase in patients with acute lymphoblastic leukemia (ALL) is unavoidable upon severe allergic reaction. We sought to examine outcomes following discontinuation due reactions. Procedure evaluated the outcome children enrolled Taiwan Pediatric Oncology Group‐2002‐ALL protocol between 2002 and 2012, who had discontinued reactions, compared those continued Erwinia (Erwinase) did not. Results Among 700 this study, 33 treatment Five‐year overall...
Real-time quantitative polymerase chain reaction (RQ-PCR) for fusion transcripts and flow cytometry leukemia-specific markers are widely used minimal residual disease (MRD) detection in acute lymphoblastic leukemia, but the relation between results of either method is unclear.Mononucleated cells from 108 bone marrow samples collected 55 B-precursor leukemia patients (30 with t(12;21)/ETV6-RUNX1, 16 t(9;22)/BCR-ABL1 nine t(1;19)/TCF3-PBX1) were examined tandem by RQ-PCR six-color...
Background Reinduction therapy has improved the outcomes in children with acute lymphoblastic leukemia (ALL). We sought to determine optimal course(s) of reinduction for standard-risk (SR, or "low-risk" other groups) patients. Also, we evaluated using triple intrathecal without cranial radiation (CrRT) central nervous system (CNS) preventive therapy. Procedure From 2002 2012, all newly diagnosed ALL Taiwan were enrolled Pediatric Oncology Group ALL-2002 protocol. SR patients randomized...
The amount of gene expression data microarray has grown exponentially. To apply them for extensive studies, integrated analysis cross-laboratory (cross-lab) becomes a trend, and thus, choosing an appropriate feature selection method is essential issue. This paper focuses on Affymetrix (Affy) studies across different labs. We investigate four methods: t-test, significance microarrays (SAM), rank products (RP), random forest (RF). methods are applied to acute lymphoblastic leukemia, myeloid...
Autoimmune neutropenia in children is caused by granulocyte-specific autoantibodies. These antibodies react to the patient's own neutrophils but disappear when spontaneously remits. This study reviewed our experience with autoimmune and investigated possible associations HLA-DR HLA-DQ alleles.From 1993 2006, laboratory received 155 blood samples from neutropenia. Of these samples, 55 had autoantibodies on indirect granulocyte immunofluorescence test. As no other disorders associated...
Objective: To report the successful use of rasburicase in two children with hyperuricemia secondary to severe rhabdomyolysis. Design: Case report. Setting: Pediatric intensive care unit a freestanding quaternary hospital. Patients: Two pediatric patients rhabdomyolysis and caused by ecstasy intoxication exertional heat stroke. Intervention: Use single low dose (6 mg) rasburicase, urate oxidase enzyme. Measurements Main Results: Rasburicase was administered on first second hospital days 6 mg...