The Minnan and Hakka people groups, the so-called "Taiwanese", are descendants of early settlers from southeast coast China during last few centuries. Genetically they showed affinities to southern Asian populations, as determined by phylogenetic trees correspondence analysis calculated HLA allele frequencies. This corresponds historically with fact that coastal indigenous population (Yueh) should therefore not be considered "pure" northern Han Chinese. A33-B58-DRB1*03...

Abstract: Taiwan’s indigenous tribes, especially the east coast tribes are not only closely related to Oceania but also with Australian aborigines. The Ivatans of Batan Islands in Philippines Yami tribe Taiwan as cultural and anthropological studies have shown. Many DRB1 alleles (*15021, *16021, *0404, *04051, *11011, *12021, *1401, *08032) high allele frequencies (>20%) certain suggesting homogeneous populations. These frequency some HLA‐A‐B‐DR haplotypes found Oceania, aborigines, south...

Abstract: Cytokine gene polymorphisms may affect their transcription, influence level of production, and be implicated in inducing susceptibility or resistance to diseases. single‐nucleotide (SNPs) were used determine allelic genotypic frequencies the Minnan, Hakka, four indigenous tribes: Ami, Tsou, Atayal, Tao (or Yami). The following cytokine analyzed: interleukin‐1α (IL‐1α) (T/C −889), IL‐1β (C/T −511, T/C +3962), IL‐1R Pst ‐I 1970), IL‐1Rα Mspa 1‐I 1100), IL‐2 (T/G −330, G/T +166), IL‐4...

Anti-"Mi(a)" is one of the most important irregular red blood cell antibodies found in Taiwan. The aim this study was to investigate whether specific HLA-DRB1 alleles are associated with anti-"Mi(a)" production.A case-control retrospective performed on 68 patients showing presence and 219 unrelated control subjects from Mackay Memorial Hospital. genotyping carried out using sequence-based typing method. Fisher's exact test 2 x contingency tables used analyze significance association between...

Autoimmune neutropenia in children is caused by granulocyte-specific autoantibodies. These antibodies react to the patient's own neutrophils but disappear when spontaneously remits. This study reviewed our experience with autoimmune and investigated possible associations HLA-DR HLA-DQ alleles.From 1993 2006, laboratory received 155 blood samples from neutropenia. Of these samples, 55 had autoantibodies on indirect granulocyte immunofluorescence test. As no other disorders associated...

BACKGROUND Isoantibodies against CD36 (platelet glycoprotein 4), developed in Type I CD36‐deficient mothers are frequently reported as the cause of fetal/neonatal alloimmune thrombocytopenia Asian population. Therefore, further detailed characterization anti‐CD36–mediated is warranted. Here, we report a patient with Taiwanese family caused by anti‐CD36 isoantibodies using novel antigen‐capture method. STUDY DESIGN AND METHODS Platelets and monocytes were analyzed for expression flow...

BACKGROUND: The human platelet antigen (HPA) 1 through 5 and the neutrophil (HNA‐1) systems are relevant to immune‐related thrombocytopenia neutropenia. alloantigen distribution profiles in population will aid estimating risk of alloimmunization. STUDY DESIGN AND METHODS: Genotyping genes that control expression HPA‐1 ‐5 HNA‐1 Taiwanese (n = 326) Taiwan's indigenous peoples 608) was performed by PCR with sequence‐specific primer (PCR‐SSP) method. RESULTS: In HPA system, HPA‐1b HPA‐4b were...

The Secretor gene (Se or FUT2), which produces alpha(1,2)-fucosyltransferase, exhibits extensive polymorphism. Six Se genes, including the weak (Se(w) Se385) and three nonsecretor alleles (se571, se685, se849) have been detected in various populations of Taiwan. distribution Lewis phenotypes among Taiwanese population groups has shown to vary considerably.A PCR-RFLP analysis system, was based on nucleotide polymorphism variation different can reveal genotype an individual easily accurately,...

The new allele A*26:236 differs from A*26:01:01:01 at position 340 (G>T) of exon 2.

Abstract Background and Objectives: The human Secre α(1,2) fucosyltransferase gene determines the ABH secretor status influences Lewis phenotype of an individual. Studies were carried out on 〈a+b‐〉 nonsecretors different groups indigenous to Taiwan demonstrate their se genotypes. Meth: blood samples was determined by a microplate method. genotypes individuals with analyzed polymerase chain reaction restriction fragment length polymorphism (PCR‐RFLP) method designed for alleles reported...

We here report a new human leukocyte antigen (HLA)‐B allele, B*460102, which differs from B*460101 by synonymous substitution at the third nucleotide of codon 74 (GAC→GAT) and independently found in three Taiwanese individuals.

We here report a new HLA‐B allele, B*9521, which differs from B*1544 at codon 67 (TCC→TGC).

Human leukocyte antigen (HLA)-DRB1*1611 has one nucleotide change at codon 14 (GAG-->AAG) from DRB1*160201, resulting in a coding Glu to Lys.

Human leukocyte antigen-DRB1*090202 has two synonymous nucleotide substitutions with DRB1*090201 at codons 57 and 58, which may be the result of a gene conversion.

Summary HLA‐A*9203, found in Taiwan using sequence‐based typing method, was identical to HLA‐A*0207 exon 3 but differed 2 by five nucleotide substitutions at positions 240–282 corresponding three amino acid changes codons 62, 66 and 70. Since this substitution motif is also seen A*11 A*03, it likely that a gene conversion event from or A*03 A*0207 backbone may have been the process used generating HLA‐A*9203.

A new human leukocyte antigen-B allele, B*5410, has been detected in Taiwan. It one nucleotide change from B*5401 at codon 156 (CTG-->CGG), resulting amino acid (L-->R).

The HLA‐B*40:238 allele has one non‐synonymous transversion from HLA‐B*40:01:01 at nucleotide position 484.