A5076801085- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Fibroblast Growth Factor Research
- Genomics, phytochemicals, and oxidative stress
- Liver Disease and Transplantation
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- Periodontal Regeneration and Treatments
- Pancreatic function and diabetes
- dental development and anomalies
- Connective Tissue Growth Factor Research
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- RNA regulation and disease
- Heme Oxygenase-1 and Carbon Monoxide
- Telomeres, Telomerase, and Senescence
- Body Contouring and Surgery
- Pluripotent Stem Cells Research
- Pediatric Hepatobiliary Diseases and Treatments
- biodegradable polymer synthesis and properties
- Cytokine Signaling Pathways and Interactions
- Hippo pathway signaling and YAP/TAZ
Kazan Federal University
2014-2020
Heinrich Heine University Düsseldorf
2014-2019
University of Groningen
2017
Ospedale Policlinico San Martino
2017
Institute of Chemical Biology and Fundamental Medicine
2017
University of Genoa
2017
Kazan State Medical University
2010-2013
Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and due to low-grade cerebral edema associated with oxidative/nitrosative stress. Recent reports suggest that cognitive impairment in cirrhotic patients may not resolve completely after an attack manifest HE. As astrocyte dysfunction central the pathogenesis HE astrocytes are critically involved synaptic plasticity, we tested for sustained function by analyzing expression levels senescence biomarkers ammonia-treated...
The use of mesenchymal stem cells (MSCs) has been shown to be promising in chronic disorders such as diabetes, Alzheimers dementia, Parkinsons disease, spinal cord injury and brain ischemia. Recent studies revealed that human tooth germs (hTG) contain MSCs which can easily isolated, expanded cryo-preserved. In this report, we isolated germ (hTGSCs) with MSC characteristics from third molar germs, cryo-preserved them at -80°C for 6 months, evaluated their surface antigens, expression...
Aim. Development of a model hindlimb ischemia in rats to assess the effectiveness gene and cell therapy.
 Methods. In first stage this approach external iliac artery was ligated immediately after bifurcation common artery. Then femoral before its branching into descending genicular, popliteal saphenous arteries with following dissection between ligatures. The second performed seven days completion stage: branches gastrocnemius muscle formed collaterals were dissected. Hindlimb blood...
Transplantation of stem cells, progenitor and differentiated cells is currently actively investigated as an approach for correcting degenerative diseases. However the mechanisms therapeutic effect cell therapy remains poorly understood. Nowadays a theory paracrine stimulation regeneration processes by transplanted through secretion trophic growth factors gains particular popularity. Genetic modification prior to transplantation allows efficient expression targeted delivery various factors....
Lately a lot of research has been focused on isolation tooth stem cells. Our earlier studies showed that odontoblasts have number features typical for ectodermal cells, such as expression epithelial membrane antigen (EMA) and cytokeratin 18. Aim: to obtain populations ectomesenchymal cells from permanent teeth pulp with properties progenitor characterize their phenotype in vitro. The 15 patients (age 18- 29) was removed according the orthodontic indications used isolation. derived studied...
For years, it is debated about the nature and localization of stem cell liver. In recent a particular interest paid to hepatic stellate cells According conducted researches, these are actively involved in restoring hepatocytes population by different liver damages they have number properties specific cells. It should be noted that able maintain viability culture differentiate into hepatocyte direction under certain conditions vitro. Interestingly, may themselves create such for progenitor...
Nowadays gene and cell therapy methods for liver diseases treatment are being actively developed. Genetic modification of cells could be an approach that considerably increases the therapeutic potential transplanted cells. It is assumed genetic manipulation, particularly obtaining application cells, express overexpress factors, reduce dose noticeably enhance effects these However, it remains unclear, how influences on cellular phenotype, in this case hepatic stellate what kind effect will...
Research in the past decade allows us to consider liver perisinusoidal cells as a possible regional stem of liver. Despite this, there is no work dedicated study their influence regeneration. The aim this was regeneration after cell transplantation rats with CCL4 and combination 2-acetylaminofluorene damage. Our results showed that both models toxic damage transplanted are found recipient's exhibit properties by differentiation into hepatocytes. Transdifferentiation injected myofibroblasts...
Most of the fundamental studies in field developing new methods for treating liver diseases regenerative medicine are performed with haematopoietic and mesenchymal stem cells. At same time more importance is gaining need finding approaches enabling stimulation regional cell compartment using cells which possibly represented by hepatic stellate But aimed at their transplantation rare. Previously, we have established possibility these to differentiate into hepatocytes after rats partial...
Chronic liver diseases of different etiology are the problem modern medicine. Nowadays is held an active search for new methods treatment these using stem cells and gene-cell therapy. One cell types, thought to be progenitor liver, - hepatic stellate cells. Previously was shown possibility differentiate into with hepatocytes phenotype after transplantation rats partial hepatectomy. In this work we studied rat regeneration on same model damage cells, transduced therapeutic genes hepatocyte...