A5000373758- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Chemical Synthesis and Analysis
- Microfluidic and Capillary Electrophoresis Applications
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Alzheimer's disease research and treatments
- Polydiacetylene-based materials and applications
- Conducting polymers and applications
- Advancements in Battery Materials
- RNA and protein synthesis mechanisms
- Microfluidic and Bio-sensing Technologies
- DNA and Nucleic Acid Chemistry
- Advanced battery technologies research
- Supercapacitor Materials and Fabrication
- Graphene research and applications
- Cholinesterase and Neurodegenerative Diseases
- Mass Spectrometry Techniques and Applications
- Dendrimers and Hyperbranched Polymers
- Biochemical and Structural Characterization
- Neurological disorders and treatments
Nankai University
2017-2025
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2023-2025
Southeast University
2017-2024
Zhejiang A & F University
2024
Shanghai Jiao Tong University
2022
Ministry of Education of the People's Republic of China
2020
Ministry of Education
2020
Constructor University
2017
University of California, Berkeley
2014-2016
Bioengineering Center
2015
Hypoxic tumors present a significant challenge in cancer therapy due to their ability adaptation low-oxygen environments, which supports tumor survival and resistance treatment. Enhanced mitophagy, the selective degradation of mitochondria by autophagy, is crucial mechanism that helps sustain cellular homeostasis hypoxic tumors. In this study, we develop an azocalix[4]arene-modified supramolecular albumin nanoparticle, co-delivers hydroxychloroquine mitochondria-targeting photosensitizer,...
The membrane transport mechanisms of cell-penetrating peptides (CPPs) are still controversial, and reliable assays to report on their internalization in model membranes required. Herein, we introduce a label-free, fluorescence-based method monitor real time. For this purpose, macrocyclic host fluorescent dye forming host–dye reporter pair encapsulated inside phospholipid vesicles. Internalization peptides, which can bind the supramolecular host, leads displacement from resulting fluorescence...
Differential sensing, which discriminates analytes via pattern recognition by sensor arrays, plays an important role in our understanding of many chemical and biological systems. However, it remains challenging to develop new methods build a unit library without incurring high workload synthesis. Herein, we propose supramolecular approach construct taking full advantage assembly. Ten arrays are developed replacing the building block combinations, adjusting ratio between system components,...
ConspectusMacrocyclic receptors can serve as alternatives to natural recognition systems tools. They provide effectively preorganized cavities encapsulate guests via host–guest interactions, thereby affecting the physiochemical properties of guests. Macrocyclic exhibit chemical and thermal stabilities higher than those thus are expected resist degradation inside body. This reduces risk harmful byproducts ensures optimal levels effectiveness. have precise molecular weights well-defined...
Abstract Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) is the primary treatment for ischemic stroke. However, rtPA can substantially increase blood‐brain barrier (BBB) permeability and susceptibility to hemorrhagic transformation. Herein, mechanism underlying side effects of investigated demonstrated that ferroptosis plays an important role. The inhibitor, liproxstatin‐1 (Lip) proposed alleviate effects. A well‐designed macrocyclic carrier, glucose‐modified...
Abstract The complex pathologies in Alzheimer's disease (AD) severely limit the effectiveness of single‐target pharmic interventions, thus necessitating multi‐pronged therapeutic strategies. While flexibility is essentially demanded constructing such multi‐target systems, for achieving optimal synergies and also accommodating inherent heterogeneity within AD. Utilizing dynamic reversibility supramolecular strategy conferring sufficient tunability component substitution proportion adjustment,...
Abstract Differential sensing, inspired by the olfactory systems in mammals, utilizes cross‐reactivity of multiple sensor units toward analytes to generate a distinctive fingerprint for each analyte. Widely acknowledged as robust analytical technique, differential sensing has entered flourishing era with advancement machine learning. Nevertheless, developing and optimizing signal transduction remain significant tasks left chemists. Macrocyclic receptors serve promising materials constructing...
Abstract Phosphorylation and dephosphorylation of peptides by kinases phosphatases is essential for signal transduction in biological systems, many diseases involve abnormal activities these enzymes. Herein, we introduce amphiphilic calixarenes as key components supramolecular, phosphorylation‐responsive membrane transport systems. Dye‐efflux experiments with liposomes demonstrated that are highly active counterion activators established cell‐penetrating peptides, EC 50 values the low...
Abstract Excess accumulation of amyloid‐β (Aβ) protein in the brain is primary pathogenesis Alzheimer's disease (AD). Inhibition Aβ fibrillation and disaggregation fibrils an attractive therapeutic preventive strategy for Aβ‐induced AD. Here, near infrared (NIR) light‐responsive nanoparticles (NPs) composed amphiphilic guanidinocalix[5]arene (GC5A), 4‐(dodecyloxy)benzamido‐terminated methoxy poly(ethylene glycol), photothermal conjugated polymer PDPP are fabricated. The NIR NPs can...
Abstract The imbalance of amyloid‐β (Aβ) production and clearance causes aggregation Aβ 1‐42 monomers to form fibrils amyloid plaques, which is an indispensable process in the pathogenesis Alzheimer's disease (AD), eventually leads pathological changes cognitive impairment. Consequently, most important target for treatment AD. However, developing a single method that can recognize , inhibit fibrillation, eliminate improve impairments, alleviate AD‐like pathology challenging. Here, coassembly...
Aqueous rechargeable zinc-ion batteries (ARZIBs) are a promising next-generation energy-storage device by virtue of the superior safety and low cost both aqueous electrolyte zinc-metal anode. However, their development is hindered lack suitable cathodes with high volumetric capacity that can provide lightweight compact size. Herein, novel cathode chemistry based on amorphous Se doped transition metal Ru mitigates resistive surface layer produced side reactions between reported. This...
Open AccessCCS ChemistryRESEARCH ARTICLE1 Sep 2021Coassembly of Macrocyclic Amphiphiles for Anti-β-Amyloid Therapy Alzheimer's Disease Yu-Chen Pan†, Hui Wang†, Xinxin Xu†, Han-Wen Tian, Hong Zhao, Xin-Yue Hu, Yu Yang Liu, Guihua Ding, Qingbin Meng, Bart Jan Ravoo, Tao Zhang and Dong-Sheng Guo Pan† College Chemistry, Key Laboratory Functional Polymer Materials, Ministry Education, State Elemento-Organic Nankai University, Tianjin 300071 , Wang† Life Sciences, Bioactive Xu† Tian Zhao Hu...
Poisoning is a leading cause of admission to medical emergency departments and intensive care units. Supramolecular detoxification, which involves injecting supramolecular receptors that bind with toxins suppress their biological activity, an emerging strategy for poisoning treatment; it has few requirements broad application scope. However, still formidable challenge design therapeutic materials as antidote macromolecular toxins, because the large size, flexible conformation, presence...
Lysine (K) is an important target residue for protein and peptide delivery across membranes. K the most frequently exposed in proteins, leading to high demand development of K-compatible transport activators. However, designing activators K-rich peptides proteins more challenging than arginine-rich species because kosmotropic nature its recognition difficulty. In this study, we designed a new amphiphilic sulfonatocalix[5]arene (sCx5-6C) as activator. sCx5-6C was tailored with two key...
Cyclic di-GMP (c-di-GMP) is a second messenger that important in regulating bacterial physiology and behavior, including motility virulence. Many questions remain about the role regulation of this signaling molecule, but current methods detection are limited by either modest sensitivity or requirements for extensive sample purification. We have taken advantage natural, high affinity receptor c-di-GMP, Vc2 riboswitch aptamer, to develop sensitive rapid electrophoretic mobility shift assay...
Abstract High-quality immunoreagents enhance the performance and reproducibility of immunoassays and, in turn, quality both biological clinical measurements. High recombinant are generated using antibody-phage display. One metric antibody – binding affinity is quantified through dissociation constant (K D ) each target antigen. To characterize K antibodies antigen, we introduce electrophoretic mobility shift assays (EMSAs) a high-throughput format suitable for small volume samples. A...
Layered transition metal dichalcogenides (TMDs) have exhibited huge potential as anode materials for sodium-ion batteries. Most of them usually store sodium via an intercalation-conversion mechanism, but niobium sulfide (NbS2) may be exception. Herein, through in situ transmission electron microscopy, we carefully investigated the insertion behaviors Na ions NbS2 and directly visualized anisotropic sodiation kinetics. Lattice-resolution imaging coupled with density functional theory...
Direct transmembrane transport plays an important role in the biomedical field. Although well-established methods exist for direct membrane of small-sized cargoes (e.g., water and ions) large-sized proteins, DNAs, polysaccharides), they are challenging to directly apply medium-sized drugs, probes, oligopeptides, growth hormones). Here, we present a negatively charged single molecular carrier, carboxyl-modified azocalix[6]arene (CAC6A), as tool that facilitates cargoes. The cellular uptake...
Uniform silver nanostructures with specific geometrical morphologies, such as triangular and hexagonal nanoplates, often exhibit unique physicochemical properties various potential applications. Despite the current progress in liquid-phase synthesis of Ag nanostructures, their growth mechanisms universally remain controversial due to lack direct visualization evidence at nanoscale. Herein, by tracking evolution trajectory nanoplates (TNPs) into (HNPs) real-time using situ liquid cell...