A5100739989- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Perovskite Materials and Applications
- Photoreceptor and optogenetics research
- Chalcogenide Semiconductor Thin Films
- Vestibular and auditory disorders
- Solid-state spectroscopy and crystallography
- Air Quality Monitoring and Forecasting
- Ichthyology and Marine Biology
- Air Quality and Health Impacts
- Identification and Quantification in Food
- Nanoplatforms for cancer theranostics
- Nicotinic Acetylcholine Receptors Study
- Atmospheric chemistry and aerosols
- Cholinesterase and Neurodegenerative Diseases
- Hereditary Neurological Disorders
- Ultrasound and Hyperthermia Applications
- Advanced Glycation End Products research
- Microbial Metabolic Engineering and Bioproduction
- Chromatin Remodeling and Cancer
- Electrochemical sensors and biosensors
- Neurological diseases and metabolism
- Genomics and Phylogenetic Studies
- Solid State Laser Technologies
- Biochemical effects in animals
Shandong University
2008-2025
State Key Laboratory of Crystal Materials
2022-2024
Shandong Provincial Hospital
2021-2024
Shandong First Medical University
2021-2024
Hebei University of Technology
2021-2023
Ministry of Education of the People's Republic of China
2023
Dalian Jiaotong University
2021-2023
Soochow University
2023
Ocean University of China
2013-2021
Central Hospital of Zibo
2021
The power conversion efficiencies (PCEs) of polycrystalline perovskite solar cells (PC–PSCs) have now reached a plateau after decade rapid development, leaving distinct gap from their Shockley-Queisser limit. To continuously mitigate the PCE deficit, nonradiative carrier losses resulting defects should be further optimized. Single-crystal perovskites are considered an ideal platform to study efficiency limit due intrinsically low defect density, as demonstrated in bulk single crystals....
Abstract Excess accumulation of amyloid‐β (Aβ) protein in the brain is primary pathogenesis Alzheimer's disease (AD). Inhibition Aβ fibrillation and disaggregation fibrils an attractive therapeutic preventive strategy for Aβ‐induced AD. Here, near infrared (NIR) light‐responsive nanoparticles (NPs) composed amphiphilic guanidinocalix[5]arene (GC5A), 4‐(dodecyloxy)benzamido‐terminated methoxy poly(ethylene glycol), photothermal conjugated polymer PDPP are fabricated. The NIR NPs can...
The regulation of reactive oxygen species (ROS)-sensitive calcium (Ca2+) channels is great significance in the treatment tumors. Here, a simple ROS generation system developed to activate ROS-sensitive ion for enhancing calcium-cascade-mediated tumor cell death under near-infrared (NIR) light irradiation. Upon irradiation with an 808 nm laser, low-lethality amount facilitates plasmid transient potential receptor melastatin-2 (pTRPM2) gene release via cleavage Se–Se bonds, which contributed...
Abstract The lateral device structure for perovskite solar cells (PSCs) has garnered significant attention, primarily due to its elimination of the need expensive transparent electrodes. However, performance devices, which are more sensitive crystal quality and charge carrier transport bottlenecks, lagged far behind predominant vertical PSCs. Herein, by modulating nucleation growth processes thin FA 0.75 MA 0.25 PbI 3 (FA = formamidinium; methylammonium) single crystals, improved, resulting...
Abstract Considering recent breakthroughs in the field of optogenetics, a powerful tool is established present study to modulate activities target neurons through application light‐based methods. Near‐infrared (NIR) light enables penetration deep‐tissue. As result, it can be used functions proteins/cells. Herein, aimed develop NIR light‐sensitive drug delivery system spatially and temporally control activation loaded at stimulation sites its release from nanoparticle sensitive NIR. Owing...
DNA methylation plays a vital role in tissue development and differentiation eukaryotes. Epigenetic studies have been seldom conducted the extremely diverse evolutionarily highly successful bilaterian lineage Mollusca. In present study, we genome-wide profiling of for five tissues bivalve mollusc, Chlamys farreri using methylation-sensitive amplification polymorphism (MSAP) technique. The levels were quite similar among tissues, ranging from 20.9% to 21.7%. CG was dominant type (14.9%–16.5%)...
Abstract Cancer cells survive by relying on oxidative stress defense against the accumulation of reactive oxygen species (ROS) during tumor formation. ROS‐sensitive TRPA1 ion channels are overexpressed in breast cancer and induce a large influx Ca 2+ which upregulates anti‐apoptotic pathway to lead produce enhance resistance ROS related chemotherapy. Targeting inhibiting critical for breaking down system overcoming cellular resistance. Here, near‐infrared (NIR) light‐responsive conjugated...
The rarity of efficient tools with spatiotemporal resolution and biocompatibility capabilities remains a major challenge for further progress application signaling manipulation. Herein, biomimetic conjugated oligomeric nanoparticles (CM-CONs) were developed to precisely modulate blood glucose homeostasis via the two-pronged activation calcium channels. Under near-infrared (NIR) laser irradiation, CM-CONs efficiently generate local heat reactive oxygen species (ROS), thereby simultaneously...
The first complete mitochondrial genome (16,537 bp) of the suborder Ammodytoidei was determined for Ammodytes personatus. includes 22 tRNAs, 2 rRNAs, and 13 protein-coding genes as well putative control region OL. gene order component are identical to those canonical vertebrate genomes. In region, all six central conserved sequence blocks (CSB-F CSB-A) having been detected only in Pleuronectiformes were recognized A. personatus, which might contribute its taxonomic resolution.
Presbycusis (PC) is characterized by preferential hearing loss at high frequencies and difficulty in speech recognition noisy environments. Previous studies have linked PC to cognitive impairment, accelerated decline incident Alzheimer’s disease. However, the neural mechanisms of impairment patients with remain unclear. Although resting-state functional magnetic resonance imaging (rs-fMRI) explored low-frequency oscillation (LFO) connectivity or amplitude PC-related activity, it remains...
The red stingray Dasyatis akajei is distributed in both marine and freshwater, but little known about its phylogeography population structure. We sampled 107 individuals from one freshwater region 6 coastal localities within the distribution range of D. akajei. Analyses first hypervariable mitochondrial DNA control 474 bp revealed only 17 polymorphism sites that defined 28 haplotypes, with no unique haplotype for population. A high level diversity low nucleotide were observed (h = 0.9393 ±...
The tunable Stokes laser characteristics based on the stimulated polariton scattering in KTiOPO4 (KTP) crystal and intracavity frequency doubling properties for are investigated first time. When pumping wavelength is 1064.2 nm, angle between beams outside KTP changes from 1.875° to 6.750°, obtained varies discontinuously 1076.5 nm 1091.4 with four gaps. pulse energy 120.0 mJ, maximum 46.5 mJ at of 1086.6 nm. By inserting a LiB3O5 (LBO) into cavity, frequency-doubled inconsecutive 538.5 543.8...
Abstract Cognitive impairment is a common symptom of multiple sclerosis and profoundly impacts quality life. Glutathione (GSH) glutamate (Glu) are tightly linked in the brain, participating cognitive function. However, GSH–Glu couplings brain regions their relationship with relapsing–remitting (RRMS) remains unclear. Forty-one RRMS patients 43 healthy controls underwent magnetic resonance spectroscopy to measure GSH Glu levels posterior cingulate cortex, medial prefrontal cortex left...
Numerous studies have revealed that the sparse spatiotemporal distributions of ground-level PM2.5 measurements affect accuracy simulation, especially in large geographical regions. However, high precision and stability make their role irreplaceable simulations. This article applies a dynamically constrained interpolation methodology (DCIM) to evaluate captured at scattered monitoring sites for national-scale simulations spatial distributions. The DCIM takes transport model as dynamic...
Objective To survey resident's capability enhancement following standardized training in Beijing 2014, and to learn existing problems insufficiency of the training. Methods A questionnaire all residents who completed their with corresponding interview resident trainers mangers. Results Residents, managers agreed that, capabilities have been improved thanks training, especially clinical skills.The most important activities is practice, scoring 8.42±2.73. Conclusion The...
In this work, chemical vapor deposition (CVD) method-grown graphene on plasma-etched quartz glass supported platinum nanoparticles (PtNPs/eQG) was constructed as an independent transparent electrode for non-enzymatic hydrogen peroxide (H2O2) detection. Graphene grown by the CVD method can effectively reduce wrinkles and pollution caused traditional transfer methods. The addition of CF4 process accelerates growth rate glass. (PtNPs) prepared in situ sputtering have favorable dispersibility...
Hereditary spastic paraplegias (HSPs) are a group of rare neurodegenerative disorders. HSPs complex disorders and clinically genetically heterogeneous. To date, more than 80 genes or genetic loci have been reported to be responsible for in Mendelian-dependent manner. Most recently, ubiquitin-associated protein 1 (UBAP1) has recognized involved HSP. Here, we identified novel truncating variants two families with pure form A deletion (c.468_469delTG) the UBAP1 gene was found first family,...
Abstract Presbycusis has been reported as related to cognitive decline, but its underlying neurophysiological mechanism is still unclear. This study aimed investigate the relationship between metabolite levels, function, and node characteristics in presbycusis based on graph theory methods. Eighty-four elderly individuals with 63 age-matched normal hearing controls underwent magnetic resonance spectroscopy, functional imaging scans, audiological assessment, assessment. Compared group,...
ABSTRACT Sensory deprivation theory is an important hypothesis involving potential pathways between hearing loss and cognitive impairment in patients with presbycusis. The suggests that prolonged auditory presbycusis, including neural deafferentation, cortical reallocation, atrophy, causes long‐lasting changes reorganization brain structure function. However, neurophysiological underlying the cognition‐ear link have not been explored. In this study, we recruited 98 presbycusis 60 healthy...
Motivation: To learn more about neurophysiological changes in the cognitive-ear link presbycusis. Goal(s): explore role of excitation-inhibition (EI) balance and dynamic functional connectivity (dFC) mediating associations between hearing loss cognitive impairment presbycusis patients. Approach: MRS auditory cortex resting-state fMRI whole brain 98 patients 60 healthy controls were assessed. Results: EI dFC indices statistically different controls. Hearing can affect cognition via a...