A5039883712- Amphibian and Reptile Biology
- Primate Behavior and Ecology
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Genomic variations and chromosomal abnormalities
- Pancreatic and Hepatic Oncology Research
- Bioenergy crop production and management
- Evolutionary Game Theory and Cooperation
- Animal Vocal Communication and Behavior
- Genetic diversity and population structure
- Ecosystem dynamics and resilience
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Genetic factors in colorectal cancer
- Scientific Computing and Data Management
- Turtle Biology and Conservation
- Cancer-related Molecular Pathways
- Synthetic Organic Chemistry Methods
- Bat Biology and Ecology Studies
- DNA Repair Mechanisms
Yale University
2023-2024
Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow us to eliminate specific aneuploidies from cancer genomes. Using ReDACT, created panel isogenic have or lack common aneuploidies, and demonstrate trisomy 1q required for malignant growth harboring this alteration. Mechanistically, gaining increases the expression
The greater bamboo lemur (Prolemur simus) is a member of the Family Lemuridae that unique in their dependency on as primary food source. This Critically Endangered species lives small forest patches eastern Madagascar, occupying fraction its historical range. Here we sequence genome for first time, and provide resources future studies this can be applied across distribution.
Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow us to eliminate specific aneuploidies from cancer genomes. Using ReDACT, created panel isogenic have or lack common aneuploidies, and demonstrate trisomy 1q required for malignant growth harboring this alteration. Mechanistically, gaining increases the...
Madagascar’s dramatic climatic fluctuations mean most lemurs adjust behaviors seasonally as resource availability fluctuates. Many will adopt one of two strategies, a maximizer or an area minimizer, when adjusting to seasonal shifts in availability. However, it is unknown if and how aye-aye ( Daubentonia madagascariensis ) ranging behavior influenced by seasonality. We explored whether habitat use changed seasonally. followed aye-ayes, adult male female, the undisturbed forest Torotorofotsy,...
The most comprehensive phylogenomic reconstruction to date was generated on all nominal taxa within the lemur genus Propithecus. Over 200 wild-caught individuals were included in this study evaluate intra and interspecific relationships across genus. Ultraconserved Elements (UCEs) resulted well-supported trees. Complete mitochondrial genomes (CMGs) largely agreed with UCEs, except where a introgression detected between one clade of diademed sifaka (Propithecus diadema) Milne-Edwards (P....
Abstract Chromosomal rearrangements on the short arm of chromosome 8 cause 8p syndrome, a rare developmental disorder characterized by neurodevelopmental delays, epilepsy, and cardiac abnormalities. While significant progress has been made in managing symptoms syndrome other conditions caused large-scale chromosomal aneuploidies, no therapeutic approach yet demonstrated to target underlying disease-causing chromosome. Here, we establish two-step eliminate abnormal copy restore euploidy cells...
Ultraconserved elements (UCEs) are regions of the genome that retain partial identity across a vast number species.This retention makes UCEs especially useful for inferring otherwise intractable phylogenies.UCE partitioning acts to split UCE into three parts: variable left flank, conserved core, and right flank.The heightened variation found in flanks allows phylogenetic inferences (Baca, Alexander,
ABSTRACT In the United States, Black individuals have higher rates of cancer mortality than any other racial or ethnic group. The sources these significant disparities are not fully understood, and may include social, environmental, genetic factors that influence onset, diagnosis, treatment. Here, we examined genomic data from several large-scale patient cohorts to search for associations in chromosome copy number alterations. We found tumors self-reported patients were significantly more...