A5033088761- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Trace Elements in Health
- Biochemical and biochemical processes
- Viral Infections and Vectors
- Click Chemistry and Applications
- Alzheimer's disease research and treatments
- Pituitary Gland Disorders and Treatments
- Transgenic Plants and Applications
- Complement system in diseases
- Computational Drug Discovery Methods
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Infectious Encephalopathies and Encephalitis
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
- Meningioma and schwannoma management
Colorado State University
2017-2024
Coronavirus disease-19 (COVID-19) emerged in late 2019 China and rapidly became pandemic. As with other coronaviruses, a preponderance of evidence suggests the virus originated horseshoe bats ( Rhinolophus spp.) may have infected an intermediate host prior to spillover into humans. A significant concern is that SARS-CoV-2 could become established secondary reservoir hosts outside Asia. To assess this potential, we challenged deer mice Peromyscus maniculatus ) found robust replication upper...
Neuroinvasive infections with mosquito-borne alphaviruses such as Western equine encephalitis virus (WEEV) can cause post-encephalitic parkinsonism. To understand the mechanisms underlying these neurological effects, we examined capacity of WEEV to induce progressive neurodegeneration in outbred CD-1 mice following non-lethal encephalitic infection. Animals were experientally infected recombinant expressing firefly luciferase or dsRed (RFP) reporters and extent viral replication was...
Abstract Coronavirus disease-19 (COVID-19) emerged in November, 2019 China and rapidly became pandemic. As with other coronaviruses, a preponderance of evidence suggests the virus originated horseshoe bats ( Rhinolophus spp.) likely underwent recombination event an intermediate host prior to entry into human populations. A significant concern is that SARS-CoV-2 could become established secondary reservoir hosts outside Asia. To assess this potential, we challenged deer mice Peromyscus...
Abstract Parkinson's disease (PD) is the most common neurodegenerative movement disorder worldwide, with a greater prevalence in men than women. The etiology of PD largely unknown, although environmental exposures and neuroinflammation are linked to protein misfolding progression. Activated microglia known promote PD, but how agents interact specific innate immune signaling pathways stimulate conversion neurotoxic phenotype not well understood. To determine nuclear factor kappa B (NF‐κB)...
The emergence of COVID-19 has led to a pandemic that caused millions cases disease, variable morbidity and hundreds thousands deaths. Currently, only remdesivir dexamethasone have demonstrated limited efficacy, slightly reducing disease burden, thus novel approaches for clinical management are needed. We identified panel human monoclonal antibody clones from yeast display library with specificity the SARS-CoV-2 spike protein receptor binding domain neutralized virus in vitro . Administration...
Insectivorous Old World horseshoe bats (Rhinolophus spp.) are the likely source of ancestral SARS-CoV-2 prior to its spillover into humans and causing COVID-19 pandemic. Natural coronavirus infections appear be principally confined intestines, suggesting fecal-oral transmission; however, little is known about biology SARS-related coronaviruses in bats. Previous experimental challenges Egyptian fruit (Rousettus aegyptiacus) resulted limited infection restricted respiratory tract, whereas...
Despite significant research efforts, treatment options for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain limited. This is due in part to a lack of therapeutics that increase host defense the virus. Replication SARS-CoV-2 lung tissue associated with marked infiltration macrophages and activation innate immune inflammatory responses amplify injury. Antagonists androgen (AR) glucocorticoid (GR) receptors have shown efficacy models COVID-19 clinical studies because cell...
Insectivorous Old World horseshoe bats ( Rhinolophus spp.) are the likely source of ancestral SARS-CoV-2 prior to its spillover into humans and causing COVID-19 pandemic. Natural coronavirus infections appear be principally confined intestines, suggesting fecal-oral transmission; however, little is known about biology SARS-related coronaviruses in bats. Previous experimental challenges Egyptian fruit Rousettus aegyptiacus ) resulted limited infection restricted respiratory tract, whereas...
Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages antigen presentation follicular dendritic cells (FDCs). CD21 helps activate B as part of the cell coreceptor with CD19 CD81. Differential splicing transcripts from mouse Cr2 gene generates isoforms both shared unique complement binding capacities cell-type expression. In models, genetic depletion causes...
Abstract The emergence of COVID-19 has led to a pandemic that caused millions cases disease, variable morbidity and hundreds thousands deaths. Currently, only remdesivir dexamethasone have demonstrated limited efficacy, slightly reducing disease burden, thus novel approaches for clinical management are needed. We identified panel human monoclonal antibody clones from yeast display library with specificity the SARS-CoV-2 spike protein receptor binding domain neutralized virus in vitro ....
A 6-year-old female spayed Great Dane was evaluated for acute onset cluster seizures. Magnetic resonance imaging (MRI) identified a mass in the olfactory bulbs with large mucoid component caudal to primary mass. The removed via transfrontal craniotomy and histopathology revealed tyrosine crystalline-rich, fibrous meningioma high mitotic index. Repeat MRI at 6 months showed no detectable tumor regrowth. dog is clinically normal seizures time of publication 10 after surgery. This subtype rare...
Abstract Parkinson’s disease (PD) is the most common neurodegenerative movement disorder worldwide. Current treatments for PD largely center around dopamine replacement therapies and fail to prevent progression of pathology, underscoring need neuroprotective interventions. Approaches that target neuroinflammation, which occurs prior dopaminergic neuron (DAn) loss in substantia nigra (SN), represent a promising therapeutic strategy. The glucocorticoid receptor (GR) has been implicated...
Bats are natural reservoir hosts of many important zoonotic viruses but because there few immunological reagents and breeding colonies available for infectious disease research, little is known about their immune responses to infection. We established a colony Jamaican fruit bats (
Abstract The modified phytochemical derivative, 1,1-bis(3′-indolyl)-1-(p-chlorophenyl) methane (C-DIM12), has been identified as a potential therapeutic platform based on its capacity to improve disease outcomes in models of neurodegeneration and cancer. However, comprehensive safety studies investigating pathology off-target binding have not conducted. To address this, we administered C-DIM12 orogastrically outbred male CD-1 mice for 7 days (50 mg/kg/day, 200 300 mg/kg/day) investigated...
Abstract Since its initial discovery in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID19, has spread worldwide and despite significant research efforts, treatment options remain limited. Replication SARS-CoV-2 lung is associated with marked infiltration macrophages activation innate immune inflammatory responses triggered, part, by heightened production interleukin-6 (IL-6) that recruits lymphocytes to site infection amplify tissue injury....