A5046506225- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Nitric Oxide and Endothelin Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Phosphodiesterase function and regulation
- Pain Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Anesthesia and Sedative Agents
- Renin-Angiotensin System Studies
- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Maternal Mental Health During Pregnancy and Postpartum
- Iron Metabolism and Disorders
- Veterinary Pharmacology and Anesthesia
- Child Nutrition and Water Access
Maastricht University
2017-2023
The xylazine/ketamine anesthesia test is widely used as a predictor of the emetic potential pharmacological compounds in rats. An reflex usually triggered by center, which populated with many different chemoreceptors. Inhibition α2 adrenergic receptor (α2 receptor) involved initiation reflex, and this key mechanism behind test. In study, we attempt to validate compounds. Furthermore, it was investigated whether an anti-emetic could be assessed within well. Rats were anesthetized combination...
Vascular cognitive impairment (VCI) is characterized by impairments in cerebral blood flow (CBF), endothelial function and blood-brain barrier (BBB) integrity. These processes are all physiologically regulated the nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signaling pathway. Additionally, cGMP plays an important role long-term potentiation (LTP) underlying memory formation. Therefore, targeting NO-sGC-cGMP pathway may be a therapeutic strategy for treating VCI. Hence, this study...
In this study, we investigated whether alterations in plasticity markers such as brain-derived neurotrophic factor (BDNF), p75 neurotrophin receptor (p75NTR) and tyrosine kinase B (TrkB) are underlying iron deficiency (ID)-induced cognitive impairments depleted piglets. Newborn piglets were either fed an iron-depleted diet (21mg Fe/kg) or iron-sufficient (88mg for four weeks. Subsequently, eight weeks after repletion (190-240mg found a significant decrease mature BDNF (14kDa) proBDNF (18kDa...
Abstract Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, second messenger involved memory formation, while heme-free sGC is inactive. Two compound classes can increase activity: stimulators acting on heme-bound sGC, and activators sGC. In this rodent study, we investigated the potential of novel brain-penetrant stimulator BAY-747 activator runcaciguat enhance long-term attenuate short-term deficits induced by NOS-inhibitor L-NAME. Furthermore,...
Pattern separation is a hippocampal process in which highly similar stimuli are recognized as separate representations, and deficits could lead to memory impairments neuropsychiatric disorders such schizophrenia. The 5-HT1A receptor (5-HT1AR) believed be involved these pattern processes. However, the dorsal raphe nucleus (DRN), 5-HT1AR expressed somatodendritic autoreceptor, negatively regulates serotonergic signaling, thereby counteract effects of postsynaptic receptors. Therefore, this...
Stress during pregnancy increases the risk to develop psychological disorders such as depression or in postpartum period. According neurotrophin hypothesis of depression, pathophysiology is caused by reduced neurotrophic activity brain. However, most studies only focus on molecular changes happening offspring upon gestational stress. To gain insight into potential stressed dams, C57Bl6/J mice were their first week gestation. At 28 days postpartum, hippocampus and nucleus accumbens core two...
The complex mechanism by which stress can affect sensory processes such as hearing is still poorly understood. In a previous study, the mineralocorticoid (MR) and/or glucocorticoid receptor (GR) were deleted in frontal brain regions but not cochlear using CaMKIIα-based tamoxifen-inducible Cre ERT2 /loxP approach. These mice exhibit either diminished (MR TMX cKO) or disinhibited (GR auditory nerve activity. present we observed that differentially able to compensate for altered activity...