A5007774888- Neuroscience and Neuropharmacology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Neural dynamics and brain function
- Hearing Loss and Rehabilitation
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Chemokine receptors and signaling
- Stress Responses and Cortisol
- Vestibular and auditory disorders
University of Tübingen
2022-2024
Mutations of large conductance Ca2+- and voltage-activated K+ channels (BK) are associated with cognitive impairment. Here we report that CA1 pyramidal neuron-specific conditional BK knock-out (cKO) mice display normal locomotor anxiety behavior. They do, however, exhibit impaired memory acquisition retrieval in the Morris Water Maze (MWM) when compared to littermate controls (CTRL). In line impairment vivo, electrical chemical long-term potentiation (LTP) cKO brain slices were vitro. We...
Abstract Autism spectrum disorder is discussed in the context of altered neural oscillations and imbalanced cortical excitation–inhibition origin. We studied here whether developmental changes peripheral auditory processing, while preserving basic hearing function, lead to oscillations. Local field potentials (LFPs) were recorded from auditory, visual, prefrontal cortices hippocampus Bdnf Pax2 KO mice. These mice develop an autism‐like behavioral phenotype through deletion BDNF Pax2+...
<p class="first" dir="auto" id="d3269560e120">In previous studies using different guanylyl cyclase (GC) knock-out mouse models (NO-GC, GC-B, and GC-A KO mice), we found that GCs do not greatly interfere with basic hearing function, but rather work to maintain proper temporal sound coding, fast auditory processing, adaptation injury. Both acoustic trauma age-related loss result in a of function processing. While NO-GC maintains these processes by preserving nerve fibers during early life,...
<p class="first" dir="auto" id="d1188697e171">Increasing evidence suggest the hearing loss as a leading cause of disability but also significant risk factor for cognitive decline and dementia. Older individuals often struggle with speech understanding in noisy environments, which can be due to progressive cochlear synaptopathy (loss synapses between hair cells auditory nerve fiber). It was previously demonstrated that leads poorer temporal processing (e.g., steady state responses, ASSRs)....
The complex mechanism by which stress can affect sensory processes such as hearing is still poorly understood. In a previous study, the mineralocorticoid (MR) and/or glucocorticoid receptor (GR) were deleted in frontal brain regions but not cochlear using CaMKIIα-based tamoxifen-inducible Cre ERT2 /loxP approach. These mice exhibit either diminished (MR TMX cKO) or disinhibited (GR auditory nerve activity. present we observed that differentially able to compensate for altered activity...
In light of the increasing evidence supporting a link between hearing loss and dementia, it is critical to gain better understanding nature this relationship. We have previously observed that following cochlear synaptopathy, temporal auditory processing (e.g., steady state responses, ASSRs), sustained when reduced input centrally compensated. This central compensation process was linked elevated hippocampal long-term potentiation (LTP). further that, independently age, responsiveness...