A5067157996- Forensic Toxicology and Drug Analysis
- Pharmacogenetics and Drug Metabolism
- Lung Cancer Treatments and Mutations
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer Immunotherapy and Biomarkers
- Cannabis and Cannabinoid Research
- Youth, Drugs, and Violence
- Computational Drug Discovery Methods
- Neuropeptides and Animal Physiology
- Appendicitis Diagnosis and Management
- T-cell and Retrovirus Studies
- Pharmaceutical studies and practices
- Pediatric health and respiratory diseases
- Poisoning and overdose treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacovigilance and Adverse Drug Reactions
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Infectious Diseases and Tuberculosis
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Public Health in Brazil
- Alcohol Consumption and Health Effects
- Inflammatory mediators and NSAID effects
Hospital de Clínicas de Porto Alegre
2022-2025
Universidade Federal do Rio Grande do Sul
2013-2022
Imperial College Healthcare NHS Trust
2019
Abstract Stimulant use while driving is a high-risk factor for collisions and fatalities. In recent years, several strategies to curtail impaired were employed on highways, including on-site oral fluid testing. This study evaluated four roadside testing devices (AquilaScan®, Dräger DrugTest®, Druglizer®, DrugWipe®) the detection of amphetamine, methamphetamine, cocaine in from Brazilian drivers. Overall, 8,985 screening tests conducted, LC-MS/MS analysis was performed 46% samples. Screening...
Abstract Driving under the influence of cannabis (DUIC) is increasing worldwide, and most prevalent drug after alcohol in impaired driving cases, emphasizing need for a reliable traffic enforcement strategy. ∆ 9 ‐tetrahydrocannabinol (THC) detection oral fluid has great potential identifying recent use; however, additional data are needed on sensitivities, specificities, efficiencies different devices detecting cannabinoids at roadside by police during routine safety efforts. At roadside,...
Abstract Phenprocoumon is widely used in prophylaxis and treatment of thromboembolic disorders. However, its pharmacokinetics pharmacodynamics vary according to several genetic non‐genetic factors. metabolism mediated by CYP 2 C 9 3 A enzymes. Moreover, VKORC 1 phenprocoumon target action. Therefore, the aim this study was evaluate association single nucleotide polymorphisms ( SNP s) 1, 9, 4 5 genes with variance weekly dose as well develop an algorithm for prediction based on environmental...
Warfarin is an oral anticoagulant prescribed to prevent and treat thromboembolic disorders. It has a narrow therapeutic window must have its effect controlled. Prothrombin test, expressed in INR value, used for dose management. Time range (TTR) important outcome of quality control anticoagulation therapy influenced by several factors. The aim this study was identify genetic, demographic, clinical factors that can potentially influence TTR. In total,422 patients using warfarin were...
e21140 Background: Immune checkpoint inhibitors improved outcomes of patients with advanced non-small cell lung cancer (NSCLC). KEYNOTE-024 trial demonstrated that immunotherapy was superior to platinum-based chemotherapy in the first-line setting. However, only 30% screened had programmed death receptor ligand-1 (PD-L1) expression above 50%. The prevalence biomarkers NSCLC may vary through different regions worldwide. Our study aims describe PD-L1 Brazil. Methods: Immunohistochemistry for...
Driving under the influence of cannabis is highly reported worldwide, and there a strong need for reliable traffic enforcement strategy. Point-of-collection testing (POCT) devices drug detection in oral fluid has great potential identifying impaired driving; however, efficiency these detecting cannabinoids questioned. It essential to accurately identify use, as this most common involved crashes around world after alcohol. Therefore, aim study was evaluate analytical reliability different...