A5102821980- Insect symbiosis and bacterial influences
- Parasitic Diseases Research and Treatment
- Insect and Pesticide Research
- Nail Diseases and Treatments
- Quantum Dots Synthesis And Properties
- Insect and Arachnid Ecology and Behavior
- Toxin Mechanisms and Immunotoxins
- Insect behavior and control techniques
- Aquaculture Nutrition and Growth
- Computational Drug Discovery Methods
- Aquaculture disease management and microbiota
- Insects and Parasite Interactions
- Malaria Research and Control
- Pharmaceutical studies and practices
- Autoimmune and Inflammatory Disorders
- Gut microbiota and health
- Autoimmune Bullous Skin Diseases
- Biosimilars and Bioanalytical Methods
- Mosquito-borne diseases and control
- Mycobacterium research and diagnosis
- Dermatological diseases and infestations
- Trypanosoma species research and implications
- Psoriasis: Treatment and Pathogenesis
- Studies on Chitinases and Chitosanases
University of California, Santa Cruz
2012-2019
Marine Scotland
2016
St John's Hospital
1971-1978
Institute of Dermatology
1971-1978
St. John's Hospital
1975
St. John's University
1971
While a number of studies have identified host factors that influence endosymbiont titer, little is known concerning environmental influences on titer. Here we examined nutrient impact maternally transmitted Wolbachia endosymbionts in Drosophila. We demonstrate Drosophila reared sucrose- and yeast-enriched diets exhibit increased reduced titers oogenesis, respectively. The yeast-induced depletion mediated large part by the somatic TOR insulin signaling pathways. Disrupting TORC1 with small...
Abstract Wolbachia are gram-negative, obligate, intracellular bacteria carried by a majority of insect species worldwide. Here we use Wolbachia-infected Drosophila cell line and genome-wide RNA interference (RNAi) screening to identify host factors that influence titer. By an RNAi library targeting 15,699 transcribed genes, identified 36 candidate genes dramatically reduced titer 41 increased Host gene knockdowns spanned broad array biological pathways including influenced mitochondrial...
ABSTRACT Wolbachia is an intracellular endosymbiont present in most arthropod and filarial nematode species. Transmission between hosts primarily vertical, taking place exclusively through the female germ line, although horizontal transmission has also been documented. The results of several studies indicate that spp. can undergo transfer somatic line cells during development adult flies. However, mechanisms underlying cell-to-cell remain largely unexplored. Here, we establish a tractable...
Wolbachia endosymbionts carried by filarial nematodes give rise to the neglected diseases African river blindness and lymphatic filariasis afflicting millions worldwide. Here we identify new Wolbachia-disrupting compounds conducting high-throughput cell-based chemical screens using a Wolbachia-infected, fluorescently labeled Drosophila cell line. This screen yielded several including three that resembled Albendazole, widely used anthelmintic drug targets nematode microtubules. Follow-up...
This study identifies oral, highly efficacious antiwolbachial compounds to cure filarial infections in mice.
SUMMARY Studies on infections in a hospital for diseases of the skin are described. Patients were shown to acquire staphylococci groin and chest at about same rate as nose. In contrast surgical wards, many resistant tetracycline but sensitive penicillin. Nevertheless, much epidemic spread was with typical surgical-ward strains rather than phage group II which might be thought diseases.
Journal Article SODIUM FUSIDATE IN THE TREATMENT OF EEYTHRASMA Get access DOROTHY A. SOMERVILLE, SOMERVILLE Department of Bacteriology, St John's Hospital for Diseases the Skin, Homerton Grove, London, E.9 (Drs Somerville, Noble and White), Dermatology, Beaumont Hospital, Lancaster (Dr Seville) Thomas's London Savin) Search other works by this author on: Oxford Academic Google Scholar W. C. NOBLE, NOBLE PAMELA M. WHITE, WHITE R. H. SEVILLE, SEVILLE J. SAVIN British Volume 85, Issue 5, 1...
Rainbow trout gastroenteritis (RTGE) has been the cause of acute mortality in farmed rainbow Europe since 1992. Epidemiological analysis indicated a strong association with high production levels and suggested an infectious aetiology. The condition is characterised by presence large numbers segmented filamentous bacteria (SFB) intestine, but role these disease not confirmed, part because organisms cannot be cultured. Therefore, other approaches need to developed investigate SFB RTGE. Faecal...