A5075203705- Aquaculture disease management and microbiota
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- interferon and immune responses
- Turtle Biology and Conservation
- Atherosclerosis and Cardiovascular Diseases
- Erythrocyte Function and Pathophysiology
- Gut microbiota and health
- Aquaculture Nutrition and Growth
- Cell Adhesion Molecules Research
University of Aberdeen
2014-2022
Abstract Cytokines of the TNF superfamily (TNFSF) control many immunological processes and are implicated in etiology immune disorders diseases. Despite their obvious biological importance, TNFSF repertoires species remain poorly characterized. In this study, we perform detailed bioinformatic, phylogenetic, syntenic analyses five cartilaginous fish genomes to identify repertoires. Strikingly, find that shark harbor ∼30 genes, more than any other vertebrate examined date substantially humans....
The molecular machinery required for lymphocyte development and differentiation appears to have emerged concomitantly with distinct B- T-like subsets in the ancestor of all vertebrates. TNFSF superfamily (TNFSF) members BAFF (TNFSF13/Blys) APRIL (TNFSF13) are key regulators B cell survival, activation mammals, but temporal emergence these molecules, their precise relationship newly identified gene BALM (BAFF APRIL-like molecule), not yet been elucidated. Here, resolve early evolutionary...
Rainbow trout gastroenteritis (RTGE) has been the cause of acute mortality in farmed rainbow Europe since 1992. Epidemiological analysis indicated a strong association with high production levels and suggested an infectious aetiology. The condition is characterised by presence large numbers segmented filamentous bacteria (SFB) intestine, but role these disease not confirmed, part because organisms cannot be cultured. Therefore, other approaches need to developed investigate SFB RTGE. Faecal...