A5023294840- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Posttraumatic Stress Disorder Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Traumatic Brain Injury Research
- Mental Health Research Topics
- Childhood Cancer Survivors' Quality of Life
- Neural and Behavioral Psychology Studies
- Sleep and Wakefulness Research
- Child and Adolescent Psychosocial and Emotional Development
- Neuroendocrine regulation and behavior
- Cancer-related cognitive impairment studies
- Mindfulness and Compassion Interventions
- Child Abuse and Trauma
- Cognitive Abilities and Testing
- Biochemical effects in animals
- Pediatric Pain Management Techniques
- Family Support in Illness
- Music Therapy and Health
- Dental Anxiety and Anesthesia Techniques
- Olfactory and Sensory Function Studies
- Anesthesia and Neurotoxicity Research
Wayne State University
2015-2024
Eugene Applebaum College of Pharmacy and Health Sciences
2015-2024
Allen Institute for Brain Science
2023
Icahn School of Medicine at Mount Sinai
2023
Oregon Health & Science University
2022
Royal Ottawa Mental Health Centre
2019
University of South Carolina
2019
Columbia University Irving Medical Center
2019
University of Michigan
2007-2016
VA Ann Arbor Healthcare System
2011-2014
Post-traumatic stress disorder (PTSD) is often characterized by aberrant amygdala activation and functional abnormalities in corticolimbic circuitry, as elucidated neuroimaging. These "activation" studies have primarily relied on tasks designed to induce region-specific, task-dependent brain responses limbic (e.g., amygdala) paralimbic areas through the use of aversive evocative probes. It remains unknown if these circuit exist at baseline or "at rest," absence fear/anxiety-related...
Clinical research has linked post-traumatic stress disorder (PTSD) with deficits in fear extinction. However, it is not clear whether these result from stress-related changes the acquisition or retention of extinction regulation memories by context, for example. In this study, we used single prolonged (SPS) animal model PTSD and conditioning procedures to examine effects prior traumatic on acquisition, retention, context-specificity SPS administered one week had no effect but disrupted both...
The basolateral complex of the amygdala (BLA) is critical for acquisition and expression Pavlovian fear conditioning in rats. Nonetheless, rats with neurotoxic BLA lesions can acquire conditional after overtraining (75 trials). capacity to memory may be mediated by central nucleus (CEA). To examine this issue, we examined influence CEA or reversible inactivation on freezing Rats pretraining (whether alone combination lesions) did not either context an auditory stimulus extensive...
Background Collectively, functional neuroimaging studies implicate frontal–limbic dysfunction in the pathophysiology of posttraumatic stress disorder (PTSD), as reflected by altered amygdala reactivity and deficient prefrontal responses. These neural patterns are often elicited social signals threat (fearful/angry faces) traumatic reminders (combat sounds, script-driven imagery). Although PTSD can be conceptualized a emotion dysregulation, few to date have directly investigated correlates...
Studies were performed in continuous-flow chambers to determine whether Neisseria gonorrhoeae could form a biofilm. Under these growth conditions, N. formed biofilm with or without the addition of 10 microM sodium nitrite perfusion medium. Microscopic analysis 4-day strain 1291 revealed evidence organisms embedded matrix, which was interlaced water channels. strains MS11 and FA1090 found also biofilms under same conditions. Cryofield emission scanning electron microscopy transmission...
Abstract Socioeconomic disadvantage (SED) experienced in early life is linked to a range of risk behaviors and diseases. Neuroimaging research indicates that this association mediated by functional changes corticostriatal reward systems modulate goal‐directed behavior, evaluation, affective processing. Existing has focused largely on adults within‐household measures as an index SED, despite evidence broader community‐level SED (e.g., neighborhood poverty levels) significant sometimes...
Abstract Pavlovian conditioning paradigms have become important model systems for understanding the neuroscience of behavior. In particular, studies extinction fear responses are yielding information about neural substrates anxiety disorders, such as phobias and post‐traumatic stress disorder (PTSD) in humans. These germane to mechanisms underlying behavioral interventions that suppress fear, including exposure therapy disorders. This unit describes detailed protocols examining nature...
Healthy parenting may be protective against the development of emotional psychopathology, particularly for children reared in stressful environments. Little is known, however, about brain and behavioral mechanisms underlying this association, during childhood adolescence, when disorders frequently emerge. Here, we demonstrate that psychological control, a strategy known to limit socioemotional children, associated with altered responses conflict 27 at-risk (urban, lower income) youth, ages...
Abstract Poor fear extinction learning and recall are linked to the development of fear‐based disorders, like posttraumatic stress disorder, associated with aberrant activation fear‐related neural circuitry. This includes greater amygdala during lesser hippocampal ventromedial prefrontal cortex (vmPFC) recall. Emerging data indicate that genetic variation in fatty acid amide hydrolase ( FAAH C385A; rs324420) is increased peripheral endocannabinoid (eCB) levels threat‐related reactivity....